Association of sildenafil use with age-related macular degeneration: a retrospective cohort study
Objective Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)—a major cause of global blindness—lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. L...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2024-04-01
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| Series: | BMJ Open Ophthalmology |
| Online Access: | https://bmjophth.bmj.com/content/9/1/e001525.full |
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| author | Nicola Jaime Adderley Krishnarajah Nirantharakumar Anuradhaa Subramanian Alastair K Denniston Wen Hwa Lee Ji Eun Diana Han Jesse Coker |
| author_facet | Nicola Jaime Adderley Krishnarajah Nirantharakumar Anuradhaa Subramanian Alastair K Denniston Wen Hwa Lee Ji Eun Diana Han Jesse Coker |
| author_sort | Nicola Jaime Adderley |
| collection | DOAJ |
| description | Objective Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)—a major cause of global blindness—lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. Limited studies suggest phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, may prevent AMD by increasing retinal blood flow. This study explores the potential association between sildenafil use and AMD risk in men with erectile dysfunction using UK data.Methods and analysis Using the UK’s IQVIA Medical Research Data, the study analysed 31 575 men prescribed sildenafil for erectile dysfunction and no AMD history from 2007 to 2015, matched with a comparator group of 62 155 non-sildenafil users in a 1:2 ratio, over a median follow-up of approximately three years.Results The primary outcome was the incidence of AMD in the two groups. The study found no significant difference in AMD incidence between the sildenafil users and the non-users, with an adjusted hazard ratio (HR) of 0.99 (95% CI 0.84 to 1.16), after accounting for confounders such as age, ethnicity, Townsend deprivation quintile, body mass index category, and diagnosis of hypertension and type 2 diabetes.Conclusion The study results indicated no significant association between sildenafil use and AMD prevention in UK men with erectile dysfunction, suggesting sildenafil’s protective effect on AMD is likely insignificant. |
| format | Article |
| id | doaj-art-eafb161ace6640578b32aef9171c2105 |
| institution | Kabale University |
| issn | 2397-3269 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Ophthalmology |
| spelling | doaj-art-eafb161ace6640578b32aef9171c21052025-02-06T08:15:10ZengBMJ Publishing GroupBMJ Open Ophthalmology2397-32692024-04-019110.1136/bmjophth-2023-001525Association of sildenafil use with age-related macular degeneration: a retrospective cohort studyNicola Jaime Adderley0Krishnarajah Nirantharakumar1Anuradhaa Subramanian2Alastair K Denniston3Wen Hwa Lee4Ji Eun Diana Han5Jesse Coker6National Institute for Health and Care Research Birmingham Biomedical Research Centre, Birmingham, UKSchool of Health Sciences, College of Medicine and Health, University of Birmingham, Birmingham, UKInstitute of Applied Health Research, University of Birmingham, Birmingham, UKHealth Data Research UK, London, United KingdomAction Against Age-Related Macular Degeneration, London, UKInstitute of Applied Health Research, University of Birmingham, Birmingham, UKAction Against Age-Related Macular Degeneration, London, UKObjective Despite significant advances in clinical care and understanding of the underlying pathophysiology, age-related macular degeneration (AMD)—a major cause of global blindness—lacks effective treatment to prevent the irreversible degeneration of photoreceptors leading to central vision loss. Limited studies suggest phosphodiesterase type 5 (PDE5) inhibitors, such as sildenafil, may prevent AMD by increasing retinal blood flow. This study explores the potential association between sildenafil use and AMD risk in men with erectile dysfunction using UK data.Methods and analysis Using the UK’s IQVIA Medical Research Data, the study analysed 31 575 men prescribed sildenafil for erectile dysfunction and no AMD history from 2007 to 2015, matched with a comparator group of 62 155 non-sildenafil users in a 1:2 ratio, over a median follow-up of approximately three years.Results The primary outcome was the incidence of AMD in the two groups. The study found no significant difference in AMD incidence between the sildenafil users and the non-users, with an adjusted hazard ratio (HR) of 0.99 (95% CI 0.84 to 1.16), after accounting for confounders such as age, ethnicity, Townsend deprivation quintile, body mass index category, and diagnosis of hypertension and type 2 diabetes.Conclusion The study results indicated no significant association between sildenafil use and AMD prevention in UK men with erectile dysfunction, suggesting sildenafil’s protective effect on AMD is likely insignificant.https://bmjophth.bmj.com/content/9/1/e001525.full |
| spellingShingle | Nicola Jaime Adderley Krishnarajah Nirantharakumar Anuradhaa Subramanian Alastair K Denniston Wen Hwa Lee Ji Eun Diana Han Jesse Coker Association of sildenafil use with age-related macular degeneration: a retrospective cohort study BMJ Open Ophthalmology |
| title | Association of sildenafil use with age-related macular degeneration: a retrospective cohort study |
| title_full | Association of sildenafil use with age-related macular degeneration: a retrospective cohort study |
| title_fullStr | Association of sildenafil use with age-related macular degeneration: a retrospective cohort study |
| title_full_unstemmed | Association of sildenafil use with age-related macular degeneration: a retrospective cohort study |
| title_short | Association of sildenafil use with age-related macular degeneration: a retrospective cohort study |
| title_sort | association of sildenafil use with age related macular degeneration a retrospective cohort study |
| url | https://bmjophth.bmj.com/content/9/1/e001525.full |
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