Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling

Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling

Heart failure (HF) remains a significant healthcare burden, with an unmet need for novel therapies to target the preceding pathological hypertrophy in HF patients. Here we report the development of novel conditional-siRNA (Cond-siRNA) constructs that are selectively activated by disease-specific RNA...

Full description

Saved in:
Bibliographic Details
Main Authors: Priyanka Gokulnath, Ane M. Salvador, Caleb Graham, Si-ping Han, Guoping Li, Ramaswamy Kannappan, Christopher Azzam, Michail Spanos, Lisa Scherer, Palaniappan Sethu, John Rossi, William A. Goddard, III, Saumya Das
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
siRNA
RNA therapeutics
cardiac hypertrophy
heart-on-chip model
riboswitch
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125002215
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items