Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome
The aim was to report an unusual case of insulinoma presenting with long-standing depression and primary testicular failure. We describe a 34-year-old male with clinical, laboratory, and radiologic data consistent with islet cell tumor and seminiferous tubule failure primary hypogonadism. The litera...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2013/926385 |
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| author | Usman H. Malabu Durgesh Gowda Yong Mong Tan |
| author_facet | Usman H. Malabu Durgesh Gowda Yong Mong Tan |
| author_sort | Usman H. Malabu |
| collection | DOAJ |
| description | The aim was to report an unusual case of insulinoma presenting with long-standing depression and primary testicular failure. We describe a 34-year-old male with clinical, laboratory, and radiologic data consistent with islet cell tumor and seminiferous tubule failure primary hypogonadism. The literature is reviewed relative to the component of this syndrome, and a possible association is discussed. The subject was investigated for a long-standing history of depression requiring medical attention because of mental confusion and slurred speech and was found to have an insulinoma. He was diagnosed with primary gonadal failure and physical examination showed no evidence of dysmorphic features. Chromosomal analysis revealed normal 46 XY and testicular biopsy showed Sertoli cell only syndrome (SCOS). Biochemistry revealed endogenous hyperinsulinism and histology confirmed an islet cell tumor. He remained euglycemic postoperatively and on followup. From this report, we emphasize drawing clinicians' attention to the possibility of an association between insulinoma and primary testicular failure and suggest consideration of this diagnosis in patients with hypergonadotropic hypogonadism who may present with infertility. |
| format | Article |
| id | doaj-art-eaf916b5257e4429986b69a2b140ab3d |
| institution | Kabale University |
| issn | 2090-6501 2090-651X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Endocrinology |
| spelling | doaj-art-eaf916b5257e4429986b69a2b140ab3d2025-02-03T01:12:26ZengWileyCase Reports in Endocrinology2090-65012090-651X2013-01-01201310.1155/2013/926385926385Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only SyndromeUsman H. Malabu0Durgesh Gowda1Yong Mong Tan2Department of Endocrinology and Diabetes, James Cook University & Townsville Hospital, 100 Angus Smith Drive, Douglas, QLD 4814, AustraliaDepartment of Endocrinology and Diabetes, James Cook University & Townsville Hospital, 100 Angus Smith Drive, Douglas, QLD 4814, AustraliaDepartment of Endocrinology and Diabetes, James Cook University & Townsville Hospital, 100 Angus Smith Drive, Douglas, QLD 4814, AustraliaThe aim was to report an unusual case of insulinoma presenting with long-standing depression and primary testicular failure. We describe a 34-year-old male with clinical, laboratory, and radiologic data consistent with islet cell tumor and seminiferous tubule failure primary hypogonadism. The literature is reviewed relative to the component of this syndrome, and a possible association is discussed. The subject was investigated for a long-standing history of depression requiring medical attention because of mental confusion and slurred speech and was found to have an insulinoma. He was diagnosed with primary gonadal failure and physical examination showed no evidence of dysmorphic features. Chromosomal analysis revealed normal 46 XY and testicular biopsy showed Sertoli cell only syndrome (SCOS). Biochemistry revealed endogenous hyperinsulinism and histology confirmed an islet cell tumor. He remained euglycemic postoperatively and on followup. From this report, we emphasize drawing clinicians' attention to the possibility of an association between insulinoma and primary testicular failure and suggest consideration of this diagnosis in patients with hypergonadotropic hypogonadism who may present with infertility.http://dx.doi.org/10.1155/2013/926385 |
| spellingShingle | Usman H. Malabu Durgesh Gowda Yong Mong Tan Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome Case Reports in Endocrinology |
| title | Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome |
| title_full | Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome |
| title_fullStr | Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome |
| title_full_unstemmed | Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome |
| title_short | Insulinoma Presenting with Long-Standing Depression, Primary Hypogonadism, and Sertoli Cell Only Syndrome |
| title_sort | insulinoma presenting with long standing depression primary hypogonadism and sertoli cell only syndrome |
| url | http://dx.doi.org/10.1155/2013/926385 |
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