Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery
Soft, untethered microrobots composed of biocompatible materials for completing micromanipulation and drug delivery tasks in lab-on-a-chip and medical scenarios are currently being developed. Alginate holds significant potential in medical microrobotics due to its biocompatibility, biodegradability,...
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MDPI AG
2019-03-01
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| Series: | Micromachines |
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| Online Access: | https://www.mdpi.com/2072-666X/10/4/230 |
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| author | Lamar O. Mair Sagar Chowdhury Genaro A. Paredes-Juarez Maria Guix Chenghao Bi Benjamin Johnson Bradley W. English Sahar Jafari James Baker-McKee Jamelle Watson-Daniels Olivia Hale Pavel Stepanov Danica Sun Zachary Baker Chad Ropp Shailesh B. Raval Dian R. Arifin Jeff W.M. Bulte Irving N. Weinberg Emily E. Evans David J. Cappelleri |
| author_facet | Lamar O. Mair Sagar Chowdhury Genaro A. Paredes-Juarez Maria Guix Chenghao Bi Benjamin Johnson Bradley W. English Sahar Jafari James Baker-McKee Jamelle Watson-Daniels Olivia Hale Pavel Stepanov Danica Sun Zachary Baker Chad Ropp Shailesh B. Raval Dian R. Arifin Jeff W.M. Bulte Irving N. Weinberg Emily E. Evans David J. Cappelleri |
| author_sort | Lamar O. Mair |
| collection | DOAJ |
| description | Soft, untethered microrobots composed of biocompatible materials for completing micromanipulation and drug delivery tasks in lab-on-a-chip and medical scenarios are currently being developed. Alginate holds significant potential in medical microrobotics due to its biocompatibility, biodegradability, and drug encapsulation capabilities. Here, we describe the synthesis of MANiACs—Magnetically Aligned Nanorods in Alginate Capsules—for use as untethered microrobotic surface tumblers, demonstrating magnetically guided lateral tumbling via rotating magnetic fields. MANiAC translation is demonstrated on tissue surfaces as well as inclined slopes. These alginate microrobots are capable of manipulating objects over millimeter-scale distances. Finally, we demonstrate payload release capabilities of MANiACs during translational tumbling motion. |
| format | Article |
| id | doaj-art-eaf7cc47d20d4e5d9f615d47c51e1753 |
| institution | OA Journals |
| issn | 2072-666X |
| language | English |
| publishDate | 2019-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Micromachines |
| spelling | doaj-art-eaf7cc47d20d4e5d9f615d47c51e17532025-08-20T02:37:10ZengMDPI AGMicromachines2072-666X2019-03-0110423010.3390/mi10040230mi10040230Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug DeliveryLamar O. Mair0Sagar Chowdhury1Genaro A. Paredes-Juarez2Maria Guix3Chenghao Bi4Benjamin Johnson5Bradley W. English6Sahar Jafari7James Baker-McKee8Jamelle Watson-Daniels9Olivia Hale10Pavel Stepanov11Danica Sun12Zachary Baker13Chad Ropp14Shailesh B. Raval15Dian R. Arifin16Jeff W.M. Bulte17Irving N. Weinberg18Emily E. Evans19David J. Cappelleri20Weinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USARussel H. Morgan Department of Radiology, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAMulti-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USAMulti-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USAMulti-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USARussel H. Morgan Department of Radiology, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USARussel H. Morgan Department of Radiology, Division of Magnetic Resonance Research, The Johns Hopkins University School of Medicine, Baltimore, MD 21205, USAWeinberg Medical Physics, Inc., North Bethesda, MD 20852, USADepartment of Physics, Elon University, Elon, NC 27244, USAMulti-Scale Robotics and Automation Lab, School of Mechanical Engineering, Purdue University, West Lafayette, IN 47907, USASoft, untethered microrobots composed of biocompatible materials for completing micromanipulation and drug delivery tasks in lab-on-a-chip and medical scenarios are currently being developed. Alginate holds significant potential in medical microrobotics due to its biocompatibility, biodegradability, and drug encapsulation capabilities. Here, we describe the synthesis of MANiACs—Magnetically Aligned Nanorods in Alginate Capsules—for use as untethered microrobotic surface tumblers, demonstrating magnetically guided lateral tumbling via rotating magnetic fields. MANiAC translation is demonstrated on tissue surfaces as well as inclined slopes. These alginate microrobots are capable of manipulating objects over millimeter-scale distances. Finally, we demonstrate payload release capabilities of MANiACs during translational tumbling motion.https://www.mdpi.com/2072-666X/10/4/230alginate capsulesmagnetic nanorodsmagnetic microrobotstumbling robotssurface walkersrotating magnetic fields |
| spellingShingle | Lamar O. Mair Sagar Chowdhury Genaro A. Paredes-Juarez Maria Guix Chenghao Bi Benjamin Johnson Bradley W. English Sahar Jafari James Baker-McKee Jamelle Watson-Daniels Olivia Hale Pavel Stepanov Danica Sun Zachary Baker Chad Ropp Shailesh B. Raval Dian R. Arifin Jeff W.M. Bulte Irving N. Weinberg Emily E. Evans David J. Cappelleri Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery Micromachines alginate capsules magnetic nanorods magnetic microrobots tumbling robots surface walkers rotating magnetic fields |
| title | Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery |
| title_full | Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery |
| title_fullStr | Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery |
| title_full_unstemmed | Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery |
| title_short | Magnetically Aligned Nanorods in Alginate Capsules (MANiACs): Soft Matter Tumbling Robots for Manipulation and Drug Delivery |
| title_sort | magnetically aligned nanorods in alginate capsules maniacs soft matter tumbling robots for manipulation and drug delivery |
| topic | alginate capsules magnetic nanorods magnetic microrobots tumbling robots surface walkers rotating magnetic fields |
| url | https://www.mdpi.com/2072-666X/10/4/230 |
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