Mouse Models for Blistering Skin Disorders
Genetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases. In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between mutations and disease phenotypes. This review focuses...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Dermatology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2010/584353 |
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| _version_ | 1832545340052471808 |
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| author | Radhika Ganeshan Jiangli Chen Peter J. Koch |
| author_facet | Radhika Ganeshan Jiangli Chen Peter J. Koch |
| author_sort | Radhika Ganeshan |
| collection | DOAJ |
| description | Genetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases. In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between mutations and disease phenotypes. This review focuses on mice that lack the desmosomal cadherins desmoglein 3 or desmocollin 3 in stratified epithelia. A comparison of the phenotypes observed in these mouse lines is provided and the relationship between the mutant mouse phenotypes and human diseases, in particular pemphigus vulgaris, is discussed. Furthermore, we will discuss the advantages and potential limitations of genetically engineered mouse lines in our ongoing quest to understand blistering skin diseases. |
| format | Article |
| id | doaj-art-eaf38f603f2c4c76bd7538336f06d266 |
| institution | Kabale University |
| issn | 1687-6105 1687-6113 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Dermatology Research and Practice |
| spelling | doaj-art-eaf38f603f2c4c76bd7538336f06d2662025-02-03T07:26:16ZengWileyDermatology Research and Practice1687-61051687-61132010-01-01201010.1155/2010/584353584353Mouse Models for Blistering Skin DisordersRadhika Ganeshan0Jiangli Chen1Peter J. Koch2Department of Dermatology, University of Colorado Medical School, 12800 East 19th Avenue, Aurora, CO 80045, USADepartment of Dermatology, University of Colorado Medical School, 12800 East 19th Avenue, Aurora, CO 80045, USADepartment of Dermatology, University of Colorado Medical School, 12800 East 19th Avenue, Aurora, CO 80045, USAGenetically engineered mice have been essential tools for elucidating the pathological mechanisms underlying human diseases. In the case of diseases caused by impaired desmosome function, mouse models have helped to establish causal links between mutations and disease phenotypes. This review focuses on mice that lack the desmosomal cadherins desmoglein 3 or desmocollin 3 in stratified epithelia. A comparison of the phenotypes observed in these mouse lines is provided and the relationship between the mutant mouse phenotypes and human diseases, in particular pemphigus vulgaris, is discussed. Furthermore, we will discuss the advantages and potential limitations of genetically engineered mouse lines in our ongoing quest to understand blistering skin diseases.http://dx.doi.org/10.1155/2010/584353 |
| spellingShingle | Radhika Ganeshan Jiangli Chen Peter J. Koch Mouse Models for Blistering Skin Disorders Dermatology Research and Practice |
| title | Mouse Models for Blistering Skin Disorders |
| title_full | Mouse Models for Blistering Skin Disorders |
| title_fullStr | Mouse Models for Blistering Skin Disorders |
| title_full_unstemmed | Mouse Models for Blistering Skin Disorders |
| title_short | Mouse Models for Blistering Skin Disorders |
| title_sort | mouse models for blistering skin disorders |
| url | http://dx.doi.org/10.1155/2010/584353 |
| work_keys_str_mv | AT radhikaganeshan mousemodelsforblisteringskindisorders AT jianglichen mousemodelsforblisteringskindisorders AT peterjkoch mousemodelsforblisteringskindisorders |