Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema
D-Penicillamine administered orally in daily doses of 300 mg or 400 mg to pregnant rats during the last six days of gestation caused marked growth retardation, a decrease in the lung weight to body weight ratio and histological features characteristic of pulmonary emphysema in the newborn ani...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
1989-07-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3849 |
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| _version_ | 1849772704489537536 |
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| author | M Yurdakök H Topaloğlu R Haziroğlu |
| author_facet | M Yurdakök H Topaloğlu R Haziroğlu |
| author_sort | M Yurdakök |
| collection | DOAJ |
| description |
D-Penicillamine administered orally in daily doses of 300 mg or 400 mg to pregnant rats during the last six days of gestation caused marked growth retardation, a decrease in the lung weight to body weight ratio and histological features characteristic of pulmonary emphysema in the newborn animals studied. It was also demonstrated that a normal diet given to the dams for a period of three weeks after delivery did not restore the lung tissue of the offspring to normal.
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| format | Article |
| id | doaj-art-eaee5a14a54042e996dd3af96aaeded5 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1989-07-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-eaee5a14a54042e996dd3af96aaeded52025-08-20T03:02:15ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211989-07-01313Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysemaM YurdakökH TopaloğluR Haziroğlu D-Penicillamine administered orally in daily doses of 300 mg or 400 mg to pregnant rats during the last six days of gestation caused marked growth retardation, a decrease in the lung weight to body weight ratio and histological features characteristic of pulmonary emphysema in the newborn animals studied. It was also demonstrated that a normal diet given to the dams for a period of three weeks after delivery did not restore the lung tissue of the offspring to normal. https://turkjpediatr.org/article/view/3849 |
| spellingShingle | M Yurdakök H Topaloğlu R Haziroğlu Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema The Turkish Journal of Pediatrics |
| title | Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema |
| title_full | Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema |
| title_fullStr | Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema |
| title_full_unstemmed | Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema |
| title_short | Effect of D-penicillamine on the fetal lung of rats: a model for congenital emphysema |
| title_sort | effect of d penicillamine on the fetal lung of rats a model for congenital emphysema |
| url | https://turkjpediatr.org/article/view/3849 |
| work_keys_str_mv | AT myurdakok effectofdpenicillamineonthefetallungofratsamodelforcongenitalemphysema AT htopaloglu effectofdpenicillamineonthefetallungofratsamodelforcongenitalemphysema AT rhaziroglu effectofdpenicillamineonthefetallungofratsamodelforcongenitalemphysema |