Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis
Histoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients. We report a patient who developed Histoplasma pneumonia while receiving voriconazole prophylaxis at a ther...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2020/8124137 |
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| _version_ | 1832560705598914560 |
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| author | Vaibhav Agrawal Bryan J. Brinda Sherif S. Farag |
| author_facet | Vaibhav Agrawal Bryan J. Brinda Sherif S. Farag |
| author_sort | Vaibhav Agrawal |
| collection | DOAJ |
| description | Histoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients. We report a patient who developed Histoplasma pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level. The patient experienced significant clinical improvement after initiation of itraconazole pharmacotherapy. We recommend a lower threshold for evaluation for histoplasmosis in allogeneic hematopoietic stem cell transplant recipients who live in endemic regions, regardless of their antifungal prophylactic regimen. |
| format | Article |
| id | doaj-art-eae1b4d8ef144faf970e7909d4e0dc58 |
| institution | Kabale University |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-eae1b4d8ef144faf970e7909d4e0dc582025-02-03T01:27:04ZengWileyCase Reports in Hematology2090-65602090-65792020-01-01202010.1155/2020/81241378124137Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole ProphylaxisVaibhav Agrawal0Bryan J. Brinda1Sherif S. Farag2Department of Medicine, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN, USADepartment of Pharmacy, Division of Hematology-Oncology, University of Kentucky, Lexington, KY, USADepartment of Medicine, Division of Hematology and Oncology, Indiana University School of Medicine, Indianapolis, IN, USAHistoplasma capsulatum infection is a rare complication in the allogeneic stem cell transplant patients. Minimal guidance exists on how to appropriately manage histoplasmosis in these patients. We report a patient who developed Histoplasma pneumonia while receiving voriconazole prophylaxis at a therapeutic trough level. The patient experienced significant clinical improvement after initiation of itraconazole pharmacotherapy. We recommend a lower threshold for evaluation for histoplasmosis in allogeneic hematopoietic stem cell transplant recipients who live in endemic regions, regardless of their antifungal prophylactic regimen.http://dx.doi.org/10.1155/2020/8124137 |
| spellingShingle | Vaibhav Agrawal Bryan J. Brinda Sherif S. Farag Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis Case Reports in Hematology |
| title | Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis |
| title_full | Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis |
| title_fullStr | Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis |
| title_full_unstemmed | Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis |
| title_short | Histoplasma capsulatum Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient Receiving Voriconazole Prophylaxis |
| title_sort | histoplasma capsulatum infection in an allogeneic hematopoietic stem cell transplant patient receiving voriconazole prophylaxis |
| url | http://dx.doi.org/10.1155/2020/8124137 |
| work_keys_str_mv | AT vaibhavagrawal histoplasmacapsulatuminfectioninanallogeneichematopoieticstemcelltransplantpatientreceivingvoriconazoleprophylaxis AT bryanjbrinda histoplasmacapsulatuminfectioninanallogeneichematopoieticstemcelltransplantpatientreceivingvoriconazoleprophylaxis AT sherifsfarag histoplasmacapsulatuminfectioninanallogeneichematopoieticstemcelltransplantpatientreceivingvoriconazoleprophylaxis |