The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys
Abstract Objective In boys during puberty who were undergoing recombinant human growth hormone (rhGH) treatment, we compared the therapeutic efficacy on growth, and any adverse reactions, of co-therapy with either letrozole or gonadotropin-releasing hormone analog (GnRHa). Methods Fifty-six pubertal...
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2025-01-01
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| Online Access: | https://doi.org/10.1186/s12887-025-05408-y |
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| author | Ying Zhang Xin Yuan Kenneth McCormick Xiao-Hong Yang Shi-Jun Chen Rui-Min Chen |
| author_facet | Ying Zhang Xin Yuan Kenneth McCormick Xiao-Hong Yang Shi-Jun Chen Rui-Min Chen |
| author_sort | Ying Zhang |
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| description | Abstract Objective In boys during puberty who were undergoing recombinant human growth hormone (rhGH) treatment, we compared the therapeutic efficacy on growth, and any adverse reactions, of co-therapy with either letrozole or gonadotropin-releasing hormone analog (GnRHa). Methods Fifty-six pubertal growth hormone deficiency (GHD) boys were studied, they were treated with the combination of letrozole and rhGH (letrozole group, n = 28) or the combination of GnRHa and rhGH (GnRHa group, n = 28) for at least one year. Eighteen patients in the letrozole group and seventeen patients in the GnRHa group attained final adult height (FAH). Results The increase in height of the letrozole group was significantly more than the GnRHa group both in the first year [(10.37 ± 2.19) vs. (7.78 ± 1.55) cm] and at two years [(18.82 ± 2.49) vs. (13.84 ± 2.17) cm] (p < 0.05), however, there was no significant group difference in the advancement of bone age (BA) of in the first year or at two years (p > 0.05). The mean FAH in two groups were similar, but the treatment duration of the letrozole group was significantly less than GnRHa group. There was a significant body mass index (BMI) SDS increase in the letrozole vs. GnRHa groups. Of concern, bone mineral density (BMD) decreased in both groups after treatment, but more so in the letrozole cohort. Conclusion The combination of letrozole/rhGH in pubertal GHD boys was similar to GnRHa/rhGH in terms of the progression of BA and FAH, but the former co-therapy was superior in the gain of height. Disconcertingly, however, this combination may adversely affect BMI and BMD. Clinical trial registration number ChiCTR2300068405. |
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| institution | Kabale University |
| issn | 1471-2431 |
| language | English |
| publishDate | 2025-01-01 |
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| series | BMC Pediatrics |
| spelling | doaj-art-ead53647b3c147c7b97fe2421cab939a2025-01-26T12:52:56ZengBMCBMC Pediatrics1471-24312025-01-012511910.1186/s12887-025-05408-yThe efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boysYing Zhang0Xin Yuan1Kenneth McCormick2Xiao-Hong Yang3Shi-Jun Chen4Rui-Min Chen5Department of Endocrinology, Genetics and Metabolism, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology, Genetics and Metabolism, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou Children’s Hospital of Fujian Medical UniversityDivision of Pediatric Endocrinology and Diabetes, University of Alabama at BirminghamDepartment of Endocrinology, Genetics and Metabolism, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology, Genetics and Metabolism, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou Children’s Hospital of Fujian Medical UniversityDepartment of Endocrinology, Genetics and Metabolism, Fuzhou First General Hospital Affiliated with Fujian Medical University, Fuzhou Children’s Hospital of Fujian Medical UniversityAbstract Objective In boys during puberty who were undergoing recombinant human growth hormone (rhGH) treatment, we compared the therapeutic efficacy on growth, and any adverse reactions, of co-therapy with either letrozole or gonadotropin-releasing hormone analog (GnRHa). Methods Fifty-six pubertal growth hormone deficiency (GHD) boys were studied, they were treated with the combination of letrozole and rhGH (letrozole group, n = 28) or the combination of GnRHa and rhGH (GnRHa group, n = 28) for at least one year. Eighteen patients in the letrozole group and seventeen patients in the GnRHa group attained final adult height (FAH). Results The increase in height of the letrozole group was significantly more than the GnRHa group both in the first year [(10.37 ± 2.19) vs. (7.78 ± 1.55) cm] and at two years [(18.82 ± 2.49) vs. (13.84 ± 2.17) cm] (p < 0.05), however, there was no significant group difference in the advancement of bone age (BA) of in the first year or at two years (p > 0.05). The mean FAH in two groups were similar, but the treatment duration of the letrozole group was significantly less than GnRHa group. There was a significant body mass index (BMI) SDS increase in the letrozole vs. GnRHa groups. Of concern, bone mineral density (BMD) decreased in both groups after treatment, but more so in the letrozole cohort. Conclusion The combination of letrozole/rhGH in pubertal GHD boys was similar to GnRHa/rhGH in terms of the progression of BA and FAH, but the former co-therapy was superior in the gain of height. Disconcertingly, however, this combination may adversely affect BMI and BMD. Clinical trial registration number ChiCTR2300068405.https://doi.org/10.1186/s12887-025-05408-yLetrozoleRecombinant human growth hormoneGonadotropin releasingAdolescent boysShort statureGrowth hormone deficiency |
| spellingShingle | Ying Zhang Xin Yuan Kenneth McCormick Xiao-Hong Yang Shi-Jun Chen Rui-Min Chen The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys BMC Pediatrics Letrozole Recombinant human growth hormone Gonadotropin releasing Adolescent boys Short stature Growth hormone deficiency |
| title | The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys |
| title_full | The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys |
| title_fullStr | The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys |
| title_full_unstemmed | The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys |
| title_short | The efficacy and safety of rhGH treatment combined with letrozole/GnRHa in adolescent boys |
| title_sort | efficacy and safety of rhgh treatment combined with letrozole gnrha in adolescent boys |
| topic | Letrozole Recombinant human growth hormone Gonadotropin releasing Adolescent boys Short stature Growth hormone deficiency |
| url | https://doi.org/10.1186/s12887-025-05408-y |
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