Crystal structure of the possible sulindac impurity 2-(5-fluoro-2-methyl-1H-inden-3-yl)acetonitrile

Crystal structure of the possible sulindac impurity 2-(5-fluoro-2-methyl-1H-inden-3-yl)acetonitrile

The title compound,C12H10FN, was identified as a possible critical degradation impurity of sulindac, a therapeutic COX-2 inhibitor for rheumatoid arthritis. Single-crystal X-ray analysis revealed two conformationally slightly different molecules in the asymmetric unit (Z′ = 2), each containing an in...

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Bibliographic Details
Main Authors: Wu Yun-Deng, Wan Hui, Xia Yun, Ni Jie, Li Jian, Zhang Hui, Xu Xiang-Yang, Xie Jun
Format: Article
Language:English
Published: International Union of Crystallography 2025-04-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
sulindac
impurity
2-(5-fluoro-2-methyl-1h-inden-3-yl)acetonitrile
synthesis
crystal structure
Online Access:https://journals.iucr.org/paper?S2056989025002622
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