Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials
Abstract Background Postmenopausal women are more likely to experience vasomotor symptoms (VMS), such as heat sensation and sweating. Recent trials have investigated fezolinetant in the treatment of VMS in postmenopausal women. Our study aims to conduct a meta-analysis of these trials in order to es...
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2025-01-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02279-y |
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| author | Abdallah R. Allam Mohamed Salah Alhateem Abdelrahman Mohamed Mahmoud |
| author_facet | Abdallah R. Allam Mohamed Salah Alhateem Abdelrahman Mohamed Mahmoud |
| author_sort | Abdallah R. Allam |
| collection | DOAJ |
| description | Abstract Background Postmenopausal women are more likely to experience vasomotor symptoms (VMS), such as heat sensation and sweating. Recent trials have investigated fezolinetant in the treatment of VMS in postmenopausal women. Our study aims to conduct a meta-analysis of these trials in order to estimate fezolinetant’s effectiveness and safety in the management of VMS in postmenopausal women. Method We searched Cochrane, PubMed, Scopus, and Web of Science for all published randomized controlled trials. Review Manager Software was used for the meta-analysis. The quality of evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework. Results Our study contained five trials with 3295 individuals with a mean age of 54.4 years. The frequency of VMS was significantly lower in the fezolinetant group compared to the placebo group [MD = − 2.42, 95% CI (− 2.81, − 2.04), P < 0.00001]. Additionally, when compared to the placebo group, the severity of VMS was significantly lower in the fezolinetant group [SMD = − 0.36, 95% CI (− 0.46, − 0.26), P < 0.00001]. Furthermore, there was no significant difference in the incidence of treatment-emergent adverse events (TEAEs) between the fezolinetant group and the placebo group [RR = 1.02, 95% CI (0.97, 1.07), P = 0.51]. Conclusion Fezolinetant is efficient and well-tolerated in the treatment of postmenopausal women with VMS. |
| format | Article |
| id | doaj-art-ead347f2ebb14bd4b84569f07e38a23a |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | European Journal of Medical Research |
| spelling | doaj-art-ead347f2ebb14bd4b84569f07e38a23a2025-01-26T12:21:40ZengBMCEuropean Journal of Medical Research2047-783X2025-01-0130111710.1186/s40001-025-02279-yFezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trialsAbdallah R. Allam0Mohamed Salah Alhateem1Abdelrahman Mohamed Mahmoud2Faculty of Medicine, Menoufia UniversityFaculty of Medicine, Menoufia UniversityFaculty of Medicine, Menoufia UniversityAbstract Background Postmenopausal women are more likely to experience vasomotor symptoms (VMS), such as heat sensation and sweating. Recent trials have investigated fezolinetant in the treatment of VMS in postmenopausal women. Our study aims to conduct a meta-analysis of these trials in order to estimate fezolinetant’s effectiveness and safety in the management of VMS in postmenopausal women. Method We searched Cochrane, PubMed, Scopus, and Web of Science for all published randomized controlled trials. Review Manager Software was used for the meta-analysis. The quality of evidence was graded using the Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) framework. Results Our study contained five trials with 3295 individuals with a mean age of 54.4 years. The frequency of VMS was significantly lower in the fezolinetant group compared to the placebo group [MD = − 2.42, 95% CI (− 2.81, − 2.04), P < 0.00001]. Additionally, when compared to the placebo group, the severity of VMS was significantly lower in the fezolinetant group [SMD = − 0.36, 95% CI (− 0.46, − 0.26), P < 0.00001]. Furthermore, there was no significant difference in the incidence of treatment-emergent adverse events (TEAEs) between the fezolinetant group and the placebo group [RR = 1.02, 95% CI (0.97, 1.07), P = 0.51]. Conclusion Fezolinetant is efficient and well-tolerated in the treatment of postmenopausal women with VMS.https://doi.org/10.1186/s40001-025-02279-yVasomotor symptomsFezolinetantPostmenopausalMeta-analysis |
| spellingShingle | Abdallah R. Allam Mohamed Salah Alhateem Abdelrahman Mohamed Mahmoud Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials European Journal of Medical Research Vasomotor symptoms Fezolinetant Postmenopausal Meta-analysis |
| title | Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials |
| title_full | Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials |
| title_fullStr | Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials |
| title_full_unstemmed | Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials |
| title_short | Fezolinetant’s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women: a meta-analysis and GRADE evaluation of randomized controlled trials |
| title_sort | fezolinetant s efficacy and safety in treatment of vasomotor symptoms in postmenopausal women a meta analysis and grade evaluation of randomized controlled trials |
| topic | Vasomotor symptoms Fezolinetant Postmenopausal Meta-analysis |
| url | https://doi.org/10.1186/s40001-025-02279-y |
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