Molecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samples
Abstract The increasing need for rapid and cost-effective methods to quantify furan compounds in food has spurred the development of in-field analysis techniques. Addressing this demand, we present a novel, low-cost disposable sensor for the direct voltammetric detection of key furanic aldehydes – 2...
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Nature Portfolio
2025-06-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-04802-x |
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| author | Alessandra Cutaia Sofia Prosperi Camilla Zanoni Giancarla Alberti |
| author_facet | Alessandra Cutaia Sofia Prosperi Camilla Zanoni Giancarla Alberti |
| author_sort | Alessandra Cutaia |
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| description | Abstract The increasing need for rapid and cost-effective methods to quantify furan compounds in food has spurred the development of in-field analysis techniques. Addressing this demand, we present a novel, low-cost disposable sensor for the direct voltammetric detection of key furanic aldehydes – 2-furaldehyde (2-FAL), 5-hydroxymethyl-2-furaldehyde (5-HMF), and 5-methyl-2-furaldehyde (5-MFAL) – in Italian honey samples. Our approach utilizes a screen-printed voltammetric cell with a carbon-ink working electrode modified by an electropolymerized molecularly imprinted polypyrrole film (e-MIP), with 2-FAL as the template. The electropolymerization conditions for the e-MIP film were optimized using a Face-centered Central Composite Design. The sensor’s analytical performance was evaluated using square wave voltammetry (SWV) in 2-FAL standard aqueous solutions (0.1 M phosphate buffer at pH 8), and its applicability was demonstrated by quantifying furaldehydes in real honey samples via the standard additions method. Interference and recovery tests confirmed the sensor’s good performance, suggesting its potential for routine furaldehyde analysis in this food matrix. |
| format | Article |
| id | doaj-art-eacaee4dc1bb482ca2e29cd168b2e8ff |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-eacaee4dc1bb482ca2e29cd168b2e8ff2025-08-20T02:05:13ZengNature PortfolioScientific Reports2045-23222025-06-0115111510.1038/s41598-025-04802-xMolecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samplesAlessandra Cutaia0Sofia Prosperi1Camilla Zanoni2Giancarla Alberti3Department of Chemistry, University of PaviaDepartment of Chemistry, University of PaviaDepartment of Chemistry, University of PaviaDepartment of Chemistry, University of PaviaAbstract The increasing need for rapid and cost-effective methods to quantify furan compounds in food has spurred the development of in-field analysis techniques. Addressing this demand, we present a novel, low-cost disposable sensor for the direct voltammetric detection of key furanic aldehydes – 2-furaldehyde (2-FAL), 5-hydroxymethyl-2-furaldehyde (5-HMF), and 5-methyl-2-furaldehyde (5-MFAL) – in Italian honey samples. Our approach utilizes a screen-printed voltammetric cell with a carbon-ink working electrode modified by an electropolymerized molecularly imprinted polypyrrole film (e-MIP), with 2-FAL as the template. The electropolymerization conditions for the e-MIP film were optimized using a Face-centered Central Composite Design. The sensor’s analytical performance was evaluated using square wave voltammetry (SWV) in 2-FAL standard aqueous solutions (0.1 M phosphate buffer at pH 8), and its applicability was demonstrated by quantifying furaldehydes in real honey samples via the standard additions method. Interference and recovery tests confirmed the sensor’s good performance, suggesting its potential for routine furaldehyde analysis in this food matrix.https://doi.org/10.1038/s41598-025-04802-x2-furaldehydeMolecularly imprinted polymersElectropolymerized molecularly imprinted polypyrroleFuraldehydes in honeySquare wave voltammetryScreen-printed electrodes |
| spellingShingle | Alessandra Cutaia Sofia Prosperi Camilla Zanoni Giancarla Alberti Molecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samples Scientific Reports 2-furaldehyde Molecularly imprinted polymers Electropolymerized molecularly imprinted polypyrrole Furaldehydes in honey Square wave voltammetry Screen-printed electrodes |
| title | Molecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samples |
| title_full | Molecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samples |
| title_fullStr | Molecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samples |
| title_full_unstemmed | Molecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samples |
| title_short | Molecularly imprinted polypyrrole-based electrochemical sensor for furaldehydes determination in Italian honey samples |
| title_sort | molecularly imprinted polypyrrole based electrochemical sensor for furaldehydes determination in italian honey samples |
| topic | 2-furaldehyde Molecularly imprinted polymers Electropolymerized molecularly imprinted polypyrrole Furaldehydes in honey Square wave voltammetry Screen-printed electrodes |
| url | https://doi.org/10.1038/s41598-025-04802-x |
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