Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions
Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent ch...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2017/7582716 |
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| author | Miyako Suzuki Magali Millecamps Lina Naso Seiji Ohtori Chisato Mori Laura S. Stone |
| author_facet | Miyako Suzuki Magali Millecamps Lina Naso Seiji Ohtori Chisato Mori Laura S. Stone |
| author_sort | Miyako Suzuki |
| collection | DOAJ |
| description | Although the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0.25 mg/kg, 5x/week for 5 weeks] versus acute treatment with intraperitoneal morphine [10 mg/kg] and pregabalin [100 mg/kg]) in a mouse model of ovariectomized or sham-operated mice 6 months following surgery. We observed reduced BMD associated with weight gain, referred cutaneous hypersensitivity, and deep musculoskeletal pain that persisted for 6 months. Chronic bisphosphonate treatment, 6 months after ovariectomy, reversed bone loss and hypersensitivity to cold, but other behavioral indices of osteoporotic pain were unchanged. While the efficacy of acute morphine on cutaneous pain was weak, pregabalin was highly effective; deep musculoskeletal pain was intractable. In conclusion, the reversal of bone loss alone is insufficient to manage pain in chronic osteoporosis. Additional treatments, both pharmacological and nonpharmacological, should be implemented to improve quality of life for osteoporosis patients. |
| format | Article |
| id | doaj-art-eabddc6328f046d5b41e1b03ad0209af |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-eabddc6328f046d5b41e1b03ad0209af2025-02-03T01:01:37ZengWileyJournal of Osteoporosis2090-80592042-00642017-01-01201710.1155/2017/75827167582716Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological InterventionsMiyako Suzuki0Magali Millecamps1Lina Naso2Seiji Ohtori3Chisato Mori4Laura S. Stone5Center for Preventive Medical Sciences, Chiba University, Chiba, JapanFaculty of Dentistry, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, QC, H3A 1G1, CanadaFaculty of Dentistry, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, QC, H3A 1G1, CanadaDepartment of Orthopedic Surgery, Graduate School of Medicine, Chiba University, Chiba, JapanCenter for Preventive Medical Sciences, Chiba University, Chiba, JapanFaculty of Dentistry, McGill University, 2001 McGill College Avenue, Suite 500, Montreal, QC, H3A 1G1, CanadaAlthough the pathological changes in osteoporotic bones are well established, the characterization of the osteoporotic pain and its appropriate treatment are not fully elucidated. We investigated the behavioral signs of cutaneous and deep musculoskeletal pain and physical function; time-dependent changes in bone mineral density (BMD) and the emergence of the behavioral phenotype; and the effects of pharmacological interventions having different mechanisms of action (chronic intraperitoneal administration of pamidronate [0.25 mg/kg, 5x/week for 5 weeks] versus acute treatment with intraperitoneal morphine [10 mg/kg] and pregabalin [100 mg/kg]) in a mouse model of ovariectomized or sham-operated mice 6 months following surgery. We observed reduced BMD associated with weight gain, referred cutaneous hypersensitivity, and deep musculoskeletal pain that persisted for 6 months. Chronic bisphosphonate treatment, 6 months after ovariectomy, reversed bone loss and hypersensitivity to cold, but other behavioral indices of osteoporotic pain were unchanged. While the efficacy of acute morphine on cutaneous pain was weak, pregabalin was highly effective; deep musculoskeletal pain was intractable. In conclusion, the reversal of bone loss alone is insufficient to manage pain in chronic osteoporosis. Additional treatments, both pharmacological and nonpharmacological, should be implemented to improve quality of life for osteoporosis patients.http://dx.doi.org/10.1155/2017/7582716 |
| spellingShingle | Miyako Suzuki Magali Millecamps Lina Naso Seiji Ohtori Chisato Mori Laura S. Stone Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions Journal of Osteoporosis |
| title | Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions |
| title_full | Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions |
| title_fullStr | Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions |
| title_full_unstemmed | Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions |
| title_short | Chronic Osteoporotic Pain in Mice: Cutaneous and Deep Musculoskeletal Pain Are Partially Independent of Bone Resorption and Differentially Sensitive to Pharmacological Interventions |
| title_sort | chronic osteoporotic pain in mice cutaneous and deep musculoskeletal pain are partially independent of bone resorption and differentially sensitive to pharmacological interventions |
| url | http://dx.doi.org/10.1155/2017/7582716 |
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