Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India
Introduction: Radiotherapy is essential in treating primary brain tumours, but radiation-induced alopecia (RIA) remains a common side effect that significantly affects patients' quality of life (QOL). With its psychosocial impact on self-image, emotional well-being, and social interactions, alo...
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| Format: | Article |
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Zabansaraye Parsian Novin Mehr Institute
2025-06-01
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| Series: | Journal of Current Oncology and Medical Sciences |
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| Online Access: | https://submission.journalofcoms.com/index.php/JCOMS/article/view/292 |
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| author | Lalitha Nageshwari S Govardhan HB Ibrahim Khaleel Vijayath BR Akshay KT Priyadarshini T Sahana R |
| author_facet | Lalitha Nageshwari S Govardhan HB Ibrahim Khaleel Vijayath BR Akshay KT Priyadarshini T Sahana R |
| author_sort | Lalitha Nageshwari S |
| collection | DOAJ |
| description | Introduction: Radiotherapy is essential in treating primary brain tumours, but radiation-induced alopecia (RIA) remains a common side effect that significantly affects patients' quality of life (QOL). With its psychosocial impact on self-image, emotional well-being, and social interactions, alopecia warrants focused attention. This study aims to evaluate the scalp as an organ at risk by defining dose constraints that minimize RIA while maintaining optimal target coverage.
Materials and methods: A retrospective analysis was conducted on 70 patients with primary brain tumours who received focal cranial radiotherapy between January 2022 and December 2024. Scalp dose-volume histograms (DVHs) were generated from treatment planning systems, and the mean scalp dose (D mean), maximum scalp dose (D max), median volume of scalp, volume of scalp receiving ≥ 30 Gy (V30Gy), dose received by 20cc (D20cc), and 30cc (D30cc) scalp volume were recorded. RIA was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. ROC statistical analysis was performed to evaluate the predictive value of scalp dosimetric parameters for RIA severity.
Results: The median age of the cohort was 57 years, with a male-to-female ratio of 1.08:1. The median D max, D mean, V 30 Gy, D20cc were 60.4 Gy, 17.5 Gy, 19.2%, and 46.4 Gy, respectively. Grade 2 and higher RIA was observed in 63% of patients. V30Gy, either independently or in combination with Scalp D mean, was identified as a significant predictor of Grade 2 or higher RIA.
Conclusion: Optimising scalp dose parametric during radiotherapy planning may help mitigate RIA and improve QOL. |
| format | Article |
| id | doaj-art-eabdb47b9c8e4cb4bfa57e716df5db11 |
| institution | Kabale University |
| issn | 2783-3127 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Zabansaraye Parsian Novin Mehr Institute |
| record_format | Article |
| series | Journal of Current Oncology and Medical Sciences |
| spelling | doaj-art-eabdb47b9c8e4cb4bfa57e716df5db112025-08-20T03:28:18ZengZabansaraye Parsian Novin Mehr InstituteJournal of Current Oncology and Medical Sciences2783-31272025-06-015211151121Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south IndiaLalitha Nageshwari S 0Govardhan HB 1Ibrahim Khaleel 2Vijayath BR 3Akshay KT 4Priyadarshini T 5 Sahana R 6Department of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru- 560029, Karnataka, IndiaDepartment of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru- 560029, Karnataka, IndiaDepartment of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru- 560029, Karnataka, IndiaDepartment of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru- 560029, Karnataka, IndiaDepartment of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru- 560029, Karnataka, IndiaDepartment of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru- 560029, Karnataka, IndiaDepartment of Radiation Oncology, Kidwai Memorial Institute of Oncology, Bengaluru- 560029, Karnataka, IndiaIntroduction: Radiotherapy is essential in treating primary brain tumours, but radiation-induced alopecia (RIA) remains a common side effect that significantly affects patients' quality of life (QOL). With its psychosocial impact on self-image, emotional well-being, and social interactions, alopecia warrants focused attention. This study aims to evaluate the scalp as an organ at risk by defining dose constraints that minimize RIA while maintaining optimal target coverage. Materials and methods: A retrospective analysis was conducted on 70 patients with primary brain tumours who received focal cranial radiotherapy between January 2022 and December 2024. Scalp dose-volume histograms (DVHs) were generated from treatment planning systems, and the mean scalp dose (D mean), maximum scalp dose (D max), median volume of scalp, volume of scalp receiving ≥ 30 Gy (V30Gy), dose received by 20cc (D20cc), and 30cc (D30cc) scalp volume were recorded. RIA was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) version 5.0. ROC statistical analysis was performed to evaluate the predictive value of scalp dosimetric parameters for RIA severity. Results: The median age of the cohort was 57 years, with a male-to-female ratio of 1.08:1. The median D max, D mean, V 30 Gy, D20cc were 60.4 Gy, 17.5 Gy, 19.2%, and 46.4 Gy, respectively. Grade 2 and higher RIA was observed in 63% of patients. V30Gy, either independently or in combination with Scalp D mean, was identified as a significant predictor of Grade 2 or higher RIA. Conclusion: Optimising scalp dose parametric during radiotherapy planning may help mitigate RIA and improve QOL.https://submission.journalofcoms.com/index.php/JCOMS/article/view/292scalp dosimetryradiotherapy-induced alopeciaprimary brain tumoursvmatqol |
| spellingShingle | Lalitha Nageshwari S Govardhan HB Ibrahim Khaleel Vijayath BR Akshay KT Priyadarshini T Sahana R Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India Journal of Current Oncology and Medical Sciences scalp dosimetry radiotherapy-induced alopecia primary brain tumours vmat qol |
| title | Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India |
| title_full | Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India |
| title_fullStr | Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India |
| title_full_unstemmed | Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India |
| title_short | Scalp dosimetry as a predictor of radiation-induced alopecia in primary brain tumours: a retrospective study from a tertiary cancer centre in south India |
| title_sort | scalp dosimetry as a predictor of radiation induced alopecia in primary brain tumours a retrospective study from a tertiary cancer centre in south india |
| topic | scalp dosimetry radiotherapy-induced alopecia primary brain tumours vmat qol |
| url | https://submission.journalofcoms.com/index.php/JCOMS/article/view/292 |
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