Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review
Abstract Introduction Gastrointestinal stromal tumor (GIST) is rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. GIST has been found largely in the stomach, small bowel, colon and rectum, and esophagus, but about 5% are found in other locations. We...
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Japan Surgical Society
2020-10-01
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| Series: | Surgical Case Reports |
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| Online Access: | http://link.springer.com/article/10.1186/s40792-020-01038-x |
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| author | Naoki Hashizume Saki Sakamoto Suguru Fukahori Shinji Ishii Nobuyuki Saikusa Yoshinori Koga Naruki Higashidate Shiori Tsuruhisa Hirotomo Nakahara Yoshiaki Tanaka Minoru Yagi |
| author_facet | Naoki Hashizume Saki Sakamoto Suguru Fukahori Shinji Ishii Nobuyuki Saikusa Yoshinori Koga Naruki Higashidate Shiori Tsuruhisa Hirotomo Nakahara Yoshiaki Tanaka Minoru Yagi |
| author_sort | Naoki Hashizume |
| collection | DOAJ |
| description | Abstract Introduction Gastrointestinal stromal tumor (GIST) is rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. GIST has been found largely in the stomach, small bowel, colon and rectum, and esophagus, but about 5% are found in other locations. We herein report a 56-year-old woman with a GIST in perforated Meckel's diverticulum. After encountering this patient, a review of the literature found reports of 18 similar patients. Case presentation A 56-year-old woman diagnosed with galactosialidosis (β-galactosidase-neuraminidase deficiency) presented with vomiting. On contrast-enhanced computed tomography, peritonitis due to perforation of the intestine was diagnosed based on the free air and dilated loop of the small bowel. Laparotomy revealed perforation of Meckel’s diverticulitis located 50 cm from the ileocecal valve. Partial resection of the ileum, including the diverticulum, and end-to-end anastomosis of the small intestine were performed. Regarding the pathological findings, the edge of the diverticulum wall consisted of a solid mass measuring 1.0 cm in size, and the tumor cells were spindle-shaped with 1 mitosis present per 50 high-power fields. The diagnosis was established as GIST of the Meckel's diverticulum. The postoperative period was uneventful. Follow-up at two years revealed no evidence of recurrence. Conclusion GIST in perforated Meckel's diverticulum is very rare. The potential for the coexistence of GIST or other tumor should be considered in the treatment of perforated Meckel's diverticulum. |
| format | Article |
| id | doaj-art-eabbef8b68f74dbca293c5c028b6dab7 |
| institution | Kabale University |
| issn | 2198-7793 |
| language | English |
| publishDate | 2020-10-01 |
| publisher | Japan Surgical Society |
| record_format | Article |
| series | Surgical Case Reports |
| spelling | doaj-art-eabbef8b68f74dbca293c5c028b6dab72025-08-20T03:39:17ZengJapan Surgical SocietySurgical Case Reports2198-77932020-10-01611510.1186/s40792-020-01038-xGastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature reviewNaoki Hashizume0Saki Sakamoto1Suguru Fukahori2Shinji Ishii3Nobuyuki Saikusa4Yoshinori Koga5Naruki Higashidate6Shiori Tsuruhisa7Hirotomo Nakahara8Yoshiaki Tanaka9Minoru Yagi10Department of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineDepartment of Pediatric Surgery, Kurume University School of MedicineAbstract Introduction Gastrointestinal stromal tumor (GIST) is rare neoplasms of the gastrointestinal tract associated with high rates of malignant transformation. GIST has been found largely in the stomach, small bowel, colon and rectum, and esophagus, but about 5% are found in other locations. We herein report a 56-year-old woman with a GIST in perforated Meckel's diverticulum. After encountering this patient, a review of the literature found reports of 18 similar patients. Case presentation A 56-year-old woman diagnosed with galactosialidosis (β-galactosidase-neuraminidase deficiency) presented with vomiting. On contrast-enhanced computed tomography, peritonitis due to perforation of the intestine was diagnosed based on the free air and dilated loop of the small bowel. Laparotomy revealed perforation of Meckel’s diverticulitis located 50 cm from the ileocecal valve. Partial resection of the ileum, including the diverticulum, and end-to-end anastomosis of the small intestine were performed. Regarding the pathological findings, the edge of the diverticulum wall consisted of a solid mass measuring 1.0 cm in size, and the tumor cells were spindle-shaped with 1 mitosis present per 50 high-power fields. The diagnosis was established as GIST of the Meckel's diverticulum. The postoperative period was uneventful. Follow-up at two years revealed no evidence of recurrence. Conclusion GIST in perforated Meckel's diverticulum is very rare. The potential for the coexistence of GIST or other tumor should be considered in the treatment of perforated Meckel's diverticulum.http://link.springer.com/article/10.1186/s40792-020-01038-xGastrointestinal stromal tumorMeckel’s diverticulumPerforation |
| spellingShingle | Naoki Hashizume Saki Sakamoto Suguru Fukahori Shinji Ishii Nobuyuki Saikusa Yoshinori Koga Naruki Higashidate Shiori Tsuruhisa Hirotomo Nakahara Yoshiaki Tanaka Minoru Yagi Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review Surgical Case Reports Gastrointestinal stromal tumor Meckel’s diverticulum Perforation |
| title | Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review |
| title_full | Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review |
| title_fullStr | Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review |
| title_full_unstemmed | Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review |
| title_short | Gastrointestinal stromal tumor in perforated Meckel’s diverticulum: a case report and literature review |
| title_sort | gastrointestinal stromal tumor in perforated meckel s diverticulum a case report and literature review |
| topic | Gastrointestinal stromal tumor Meckel’s diverticulum Perforation |
| url | http://link.springer.com/article/10.1186/s40792-020-01038-x |
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