Brain abscess due to clostridium celerecrescens: first report and literature review
Abstract Background Brain abscess caused by atypical pathogens presents significant diagnostic and therapeutic challenges. The unusual clinical presentations, coupled with incomplete or inaccurate patient histories, often result in misdiagnosis and inappropriate treatment. Case presentation We repor...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | BMC Infectious Diseases |
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| Online Access: | https://doi.org/10.1186/s12879-025-10814-9 |
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| author | Ganzhi Liu Tiange Chen Xiaobo Tian Ying Ai Ziyang Chen Jinfang Liu Zhongyi Sun |
| author_facet | Ganzhi Liu Tiange Chen Xiaobo Tian Ying Ai Ziyang Chen Jinfang Liu Zhongyi Sun |
| author_sort | Ganzhi Liu |
| collection | DOAJ |
| description | Abstract Background Brain abscess caused by atypical pathogens presents significant diagnostic and therapeutic challenges. The unusual clinical presentations, coupled with incomplete or inaccurate patient histories, often result in misdiagnosis and inappropriate treatment. Case presentation We report a case of a retained intracranial bamboo foreign body resulting in a brain abscess. A female adolescent presented with a newly developed mass on the eyelid. Medical imaging identified a foreign body that had penetrated the frontal lobes via the transorbital route, leading to the formation of a brain abscess. The foreign body was successfully removed through transnasal endoscopy. Inflamed tissue adherent to the foreign body was cultured and analyzed using metagenomic next-generation sequencing (mNGS), which identified Clostridium celerecrescens as the causative pathogen. The patient fully recovered after surgical debridement and two weeks of antibiotic therapy. Conclusions Infections caused by C. celerecrescens are exceedingly rare in clinical practice. This case highlights the bacterium’s ability to adhere to a bamboo foreign body, leading to the formation of a rare brain abscess. mNGS proves to be a valuable diagnostic tool for identifying uncommon infectious agents. |
| format | Article |
| id | doaj-art-eab3e5cb132e4f9996314c3f397b7d44 |
| institution | DOAJ |
| issn | 1471-2334 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj-art-eab3e5cb132e4f9996314c3f397b7d442025-08-20T02:51:23ZengBMCBMC Infectious Diseases1471-23342025-03-012511610.1186/s12879-025-10814-9Brain abscess due to clostridium celerecrescens: first report and literature reviewGanzhi Liu0Tiange Chen1Xiaobo Tian2Ying Ai3Ziyang Chen4Jinfang Liu5Zhongyi Sun6Department of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityDepartment of Neurosurgery, Xiangya Hospital, Central South UniversityAbstract Background Brain abscess caused by atypical pathogens presents significant diagnostic and therapeutic challenges. The unusual clinical presentations, coupled with incomplete or inaccurate patient histories, often result in misdiagnosis and inappropriate treatment. Case presentation We report a case of a retained intracranial bamboo foreign body resulting in a brain abscess. A female adolescent presented with a newly developed mass on the eyelid. Medical imaging identified a foreign body that had penetrated the frontal lobes via the transorbital route, leading to the formation of a brain abscess. The foreign body was successfully removed through transnasal endoscopy. Inflamed tissue adherent to the foreign body was cultured and analyzed using metagenomic next-generation sequencing (mNGS), which identified Clostridium celerecrescens as the causative pathogen. The patient fully recovered after surgical debridement and two weeks of antibiotic therapy. Conclusions Infections caused by C. celerecrescens are exceedingly rare in clinical practice. This case highlights the bacterium’s ability to adhere to a bamboo foreign body, leading to the formation of a rare brain abscess. mNGS proves to be a valuable diagnostic tool for identifying uncommon infectious agents.https://doi.org/10.1186/s12879-025-10814-9Clostridium celerecrescensNext-generation sequencingBrain abscessForeign bodyCase report |
| spellingShingle | Ganzhi Liu Tiange Chen Xiaobo Tian Ying Ai Ziyang Chen Jinfang Liu Zhongyi Sun Brain abscess due to clostridium celerecrescens: first report and literature review BMC Infectious Diseases Clostridium celerecrescens Next-generation sequencing Brain abscess Foreign body Case report |
| title | Brain abscess due to clostridium celerecrescens: first report and literature review |
| title_full | Brain abscess due to clostridium celerecrescens: first report and literature review |
| title_fullStr | Brain abscess due to clostridium celerecrescens: first report and literature review |
| title_full_unstemmed | Brain abscess due to clostridium celerecrescens: first report and literature review |
| title_short | Brain abscess due to clostridium celerecrescens: first report and literature review |
| title_sort | brain abscess due to clostridium celerecrescens first report and literature review |
| topic | Clostridium celerecrescens Next-generation sequencing Brain abscess Foreign body Case report |
| url | https://doi.org/10.1186/s12879-025-10814-9 |
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