Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular Risk
Introduction: the metabolic syndrome is becoming one of the main problems in public health. Objective: to evaluate the relation between metabolic syndrome and uric acid, high sensitivity c reactive protein, total cardiovascular risk and cardiovascular events. Methods: a study of cases controls nes...
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Universidad de Ciencias Médicas de Holguín
2017-02-01
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| Series: | Correo Científico Médico |
| Online Access: | https://revcocmed.sld.cu/index.php/cocmed/article/view/2304 |
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| author | Jorge Vega Abascal Mayra Rosa Guimara Mosqueda Luis Vega Abascal |
| author_facet | Jorge Vega Abascal Mayra Rosa Guimara Mosqueda Luis Vega Abascal |
| author_sort | Jorge Vega Abascal |
| collection | DOAJ |
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Introduction: the metabolic syndrome is becoming one of the main problems in public health.
Objective: to evaluate the relation between metabolic syndrome and uric acid, high sensitivity c reactive protein, total cardiovascular risk and cardiovascular events. Methods: a study of cases controls nested in a dynamic cohort was carried out in Velasco Teaching Polyclinic from 2010 to 2015, the cases were 67 patients that developed metabolic syndrome during the period and the control group were 67 patients matched by sex and age ± 5 years. The participants underwent a physical examination, anthropometry, laboratory test; all the study participants were under continuous surveillance during 4.5 years for development of cardiovascular events.
Results: the waist circumference (p = 0.000), systolic (p= 0.0042) and diastolic blood pressure (p= 0.0298), high sensitivity c reactive protein (p= 0.0039) and uric acid (p= 0.0283) were significantly associate in both groups. The body mass index was higher than 30 kg/m2 (OR 7.54; CI95%:3.35-16.9), LDL cholesterol greater than 4.16 mmol/l (OR 3.49; CI 95%:1.58-7.70) and hs CRP higher than 1 mg/dl (OR 3.59; CI 95%:1.51-8.51) showed statistically significant differences according to groups of studies. Global cardiovascular risk greater 20%, it was 3.84 times higher in the group with metabolic syndrome (CI 95%:1.67-8.82), 13.4% of the patients with metabolic syndrome developed a cardiovascular event during the period in comparison with the 2.9% in the group without metabolic syndrome (OR= 5.04; CI 95%: 1.04-24.3).
Conclusions: metabolic syndrome was significantly associated with mean level of uric acid, high sensitivity c reactive protein, total cardiovascular risk and cardiovascular events.
Keywords: metabolic syndrome, high sensitivity c reactive protein, uric acid, total cardiovascular risk, primary health care
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| format | Article |
| id | doaj-art-eaa6fb23498d42ba98a1bc4e34b7378c |
| institution | Kabale University |
| issn | 2708-5481 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Universidad de Ciencias Médicas de Holguín |
| record_format | Article |
| series | Correo Científico Médico |
| spelling | doaj-art-eaa6fb23498d42ba98a1bc4e34b7378c2025-08-20T03:31:49ZengUniversidad de Ciencias Médicas de HolguínCorreo Científico Médico2708-54812017-02-01211Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular RiskJorge Vega Abascal0Mayra Rosa Guimara MosquedaLuis Vega AbascalPoliclinico Docente Jose Avila Serrano. Velasco. Holguin Introduction: the metabolic syndrome is becoming one of the main problems in public health. Objective: to evaluate the relation between metabolic syndrome and uric acid, high sensitivity c reactive protein, total cardiovascular risk and cardiovascular events. Methods: a study of cases controls nested in a dynamic cohort was carried out in Velasco Teaching Polyclinic from 2010 to 2015, the cases were 67 patients that developed metabolic syndrome during the period and the control group were 67 patients matched by sex and age ± 5 years. The participants underwent a physical examination, anthropometry, laboratory test; all the study participants were under continuous surveillance during 4.5 years for development of cardiovascular events. Results: the waist circumference (p = 0.000), systolic (p= 0.0042) and diastolic blood pressure (p= 0.0298), high sensitivity c reactive protein (p= 0.0039) and uric acid (p= 0.0283) were significantly associate in both groups. The body mass index was higher than 30 kg/m2 (OR 7.54; CI95%:3.35-16.9), LDL cholesterol greater than 4.16 mmol/l (OR 3.49; CI 95%:1.58-7.70) and hs CRP higher than 1 mg/dl (OR 3.59; CI 95%:1.51-8.51) showed statistically significant differences according to groups of studies. Global cardiovascular risk greater 20%, it was 3.84 times higher in the group with metabolic syndrome (CI 95%:1.67-8.82), 13.4% of the patients with metabolic syndrome developed a cardiovascular event during the period in comparison with the 2.9% in the group without metabolic syndrome (OR= 5.04; CI 95%: 1.04-24.3). Conclusions: metabolic syndrome was significantly associated with mean level of uric acid, high sensitivity c reactive protein, total cardiovascular risk and cardiovascular events. Keywords: metabolic syndrome, high sensitivity c reactive protein, uric acid, total cardiovascular risk, primary health care https://revcocmed.sld.cu/index.php/cocmed/article/view/2304 |
| spellingShingle | Jorge Vega Abascal Mayra Rosa Guimara Mosqueda Luis Vega Abascal Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular Risk Correo Científico Médico |
| title | Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular Risk |
| title_full | Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular Risk |
| title_fullStr | Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular Risk |
| title_full_unstemmed | Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular Risk |
| title_short | Beyond the Definition of Metabolic Syndrome: Uric Acid, High Sensitivity C Reactive Protein and Global Cardiovascular Risk |
| title_sort | beyond the definition of metabolic syndrome uric acid high sensitivity c reactive protein and global cardiovascular risk |
| url | https://revcocmed.sld.cu/index.php/cocmed/article/view/2304 |
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