Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia
Background. Serum hemeoxygenase-1 (HO-1) has been proposed to be a biomarker of lung disease activity and prognosis. The present study aimed at evaluating whether HO-1 could be a useful marker for evaluating disease activity and predicting prognosis in patients with interstitial pneumonia (IP). Mate...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
|
| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2018/7260178 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849692574382555136 |
|---|---|
| author | Kota Murohashi Yu Hara Kanako Shinada Kenjiro Nagai Masaharu Shinkai Akihiko Kawana Takeshi Kaneko |
| author_facet | Kota Murohashi Yu Hara Kanako Shinada Kenjiro Nagai Masaharu Shinkai Akihiko Kawana Takeshi Kaneko |
| author_sort | Kota Murohashi |
| collection | DOAJ |
| description | Background. Serum hemeoxygenase-1 (HO-1) has been proposed to be a biomarker of lung disease activity and prognosis. The present study aimed at evaluating whether HO-1 could be a useful marker for evaluating disease activity and predicting prognosis in patients with interstitial pneumonia (IP). Materials and Methods. Serum HO-1 levels of newly diagnosed or untreated patients with IP were measured at hospitalization. We evaluated the relationships between serum HO-1 and other serum biomarkers, high resolution CT (HRCT) findings, and hospital mortality. Results. Twenty-eight patients with IP, including 14 having an acute exacerbation (AE) and 14 not having an AE, were evaluated. The patients having an AE had significantly higher HO-1 levels than those not having an AE (53.5 ng/mL vs. 24.1 ng/mL; p<0.001), and the best cut-off level to discriminate between having an AE or not having an AE was 41.6 ng/mL. Serum HO-1 levels were positively correlated with serum levels of surfactant protein-D (r=0.66, p<0.001) and the ground glass opacity score (calculated from HRCT; r=0.40, p=0.036). Patients who subsequently died in hospital had presented with significantly higher HO-1 levels than those who did not die in hospital (64.8 ng/mL vs. 32.0 ng/mL; p=0.009). Conclusion. Serum HO-1 may serve as a useful biomarker for detecting AE or predicting hospital mortality in patients with IP. |
| format | Article |
| id | doaj-art-eaa6c19c8b2f47789c1e55f95386c872 |
| institution | DOAJ |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-eaa6c19c8b2f47789c1e55f95386c8722025-08-20T03:20:39ZengWileyCanadian Respiratory Journal1198-22411916-72452018-01-01201810.1155/2018/72601787260178Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial PneumoniaKota Murohashi0Yu Hara1Kanako Shinada2Kenjiro Nagai3Masaharu Shinkai4Akihiko Kawana5Takeshi Kaneko6Department of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, JapanDivision of Infectious Diseases and Pulmonary Medicine, Department of Internal Medicine, National Defense Medical College, Saitama, JapanDepartment of Pulmonology, Yokohama City University Graduate School of Medicine, Yokohama, JapanBackground. Serum hemeoxygenase-1 (HO-1) has been proposed to be a biomarker of lung disease activity and prognosis. The present study aimed at evaluating whether HO-1 could be a useful marker for evaluating disease activity and predicting prognosis in patients with interstitial pneumonia (IP). Materials and Methods. Serum HO-1 levels of newly diagnosed or untreated patients with IP were measured at hospitalization. We evaluated the relationships between serum HO-1 and other serum biomarkers, high resolution CT (HRCT) findings, and hospital mortality. Results. Twenty-eight patients with IP, including 14 having an acute exacerbation (AE) and 14 not having an AE, were evaluated. The patients having an AE had significantly higher HO-1 levels than those not having an AE (53.5 ng/mL vs. 24.1 ng/mL; p<0.001), and the best cut-off level to discriminate between having an AE or not having an AE was 41.6 ng/mL. Serum HO-1 levels were positively correlated with serum levels of surfactant protein-D (r=0.66, p<0.001) and the ground glass opacity score (calculated from HRCT; r=0.40, p=0.036). Patients who subsequently died in hospital had presented with significantly higher HO-1 levels than those who did not die in hospital (64.8 ng/mL vs. 32.0 ng/mL; p=0.009). Conclusion. Serum HO-1 may serve as a useful biomarker for detecting AE or predicting hospital mortality in patients with IP.http://dx.doi.org/10.1155/2018/7260178 |
| spellingShingle | Kota Murohashi Yu Hara Kanako Shinada Kenjiro Nagai Masaharu Shinkai Akihiko Kawana Takeshi Kaneko Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia Canadian Respiratory Journal |
| title | Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia |
| title_full | Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia |
| title_fullStr | Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia |
| title_full_unstemmed | Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia |
| title_short | Clinical Significance of Serum Hemeoxygenase-1 as a New Biomarker for the Patients with Interstitial Pneumonia |
| title_sort | clinical significance of serum hemeoxygenase 1 as a new biomarker for the patients with interstitial pneumonia |
| url | http://dx.doi.org/10.1155/2018/7260178 |
| work_keys_str_mv | AT kotamurohashi clinicalsignificanceofserumhemeoxygenase1asanewbiomarkerforthepatientswithinterstitialpneumonia AT yuhara clinicalsignificanceofserumhemeoxygenase1asanewbiomarkerforthepatientswithinterstitialpneumonia AT kanakoshinada clinicalsignificanceofserumhemeoxygenase1asanewbiomarkerforthepatientswithinterstitialpneumonia AT kenjironagai clinicalsignificanceofserumhemeoxygenase1asanewbiomarkerforthepatientswithinterstitialpneumonia AT masaharushinkai clinicalsignificanceofserumhemeoxygenase1asanewbiomarkerforthepatientswithinterstitialpneumonia AT akihikokawana clinicalsignificanceofserumhemeoxygenase1asanewbiomarkerforthepatientswithinterstitialpneumonia AT takeshikaneko clinicalsignificanceofserumhemeoxygenase1asanewbiomarkerforthepatientswithinterstitialpneumonia |