Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas
Background: The prognosis of colorectal cancer patients is to a considerable extent determined by the metastatic potency of the primary tumor. However, despite the fact that liver metastases are the leading cause of death for cancer patients, the molecular basis still remains poorly understood and i...
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| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2006-01-01
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| Series: | Cellular Oncology |
| Online Access: | http://dx.doi.org/10.1155/2006/529190 |
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| author | B. Michael Ghadimi Marian Grade Carsten Mönkemeyer Bettina Kulle Jochen Gaedcke Bastian Gunawan Claus Langer Torsten Liersch Heinz Becker |
| author_facet | B. Michael Ghadimi Marian Grade Carsten Mönkemeyer Bettina Kulle Jochen Gaedcke Bastian Gunawan Claus Langer Torsten Liersch Heinz Becker |
| author_sort | B. Michael Ghadimi |
| collection | DOAJ |
| description | Background: The prognosis of colorectal cancer patients is to a considerable extent determined by the metastatic potency of the primary tumor. However, despite the fact that liver metastases are the leading cause of death for cancer patients, the molecular basis still remains poorly understood and independent prognostic markers have not been established. Materials and methods: Comparative genomic hybridization (CGH) was used to screen colorectal carcinomas without distant metastases (n=18) and carcinomas synchronously metastatic to the liver (n=18). We aimed to detect distinct chromosomal aberrations indicating a metastatic phenotype. Results and discussion: Metastatic tumors exhibited a significantly (P=0.03) higher ANCA value (13.8) if compared with non-metastatic cancers (10.0). Furthermore, we observed that losses of chromosomal regions 1p32-ter and 9q33-ter were present at much higher frequencies in metastatic than in non-metastatic cancers, respectively (P=0.02 and 0.04). Conclusion: These data indicate that metastatic tumors may be separated from non-metastatic colorectal cancers based on their genomic profile. |
| format | Article |
| id | doaj-art-eaa5e8aafe914b08aff41a4a915f1296 |
| institution | Kabale University |
| issn | 1570-5870 1875-8606 |
| language | English |
| publishDate | 2006-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cellular Oncology |
| spelling | doaj-art-eaa5e8aafe914b08aff41a4a915f12962025-02-03T01:33:02ZengWileyCellular Oncology1570-58701875-86062006-01-01285-627328110.1155/2006/529190Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal CarcinomasB. Michael Ghadimi0Marian Grade1Carsten Mönkemeyer2Bettina Kulle3Jochen Gaedcke4Bastian Gunawan5Claus Langer6Torsten Liersch7Heinz Becker8Department of General Surgery, University Medical Center, Göttingen, GermanyDepartment of General Surgery, University Medical Center, Göttingen, GermanyDepartment of General Surgery, University Medical Center, Göttingen, GermanyDepartment of Genetic Epidemiology, University Medical Center, Göttingen, GermanyDepartment of General Surgery, University Medical Center, Göttingen, GermanyDepartment of Pathology, University Medical Center, Göttingen, GermanyDepartment of General Surgery, University Medical Center, Göttingen, GermanyDepartment of General Surgery, University Medical Center, Göttingen, GermanyDepartment of General Surgery, University Medical Center, Göttingen, GermanyBackground: The prognosis of colorectal cancer patients is to a considerable extent determined by the metastatic potency of the primary tumor. However, despite the fact that liver metastases are the leading cause of death for cancer patients, the molecular basis still remains poorly understood and independent prognostic markers have not been established. Materials and methods: Comparative genomic hybridization (CGH) was used to screen colorectal carcinomas without distant metastases (n=18) and carcinomas synchronously metastatic to the liver (n=18). We aimed to detect distinct chromosomal aberrations indicating a metastatic phenotype. Results and discussion: Metastatic tumors exhibited a significantly (P=0.03) higher ANCA value (13.8) if compared with non-metastatic cancers (10.0). Furthermore, we observed that losses of chromosomal regions 1p32-ter and 9q33-ter were present at much higher frequencies in metastatic than in non-metastatic cancers, respectively (P=0.02 and 0.04). Conclusion: These data indicate that metastatic tumors may be separated from non-metastatic colorectal cancers based on their genomic profile.http://dx.doi.org/10.1155/2006/529190 |
| spellingShingle | B. Michael Ghadimi Marian Grade Carsten Mönkemeyer Bettina Kulle Jochen Gaedcke Bastian Gunawan Claus Langer Torsten Liersch Heinz Becker Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas Cellular Oncology |
| title | Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas |
| title_full | Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas |
| title_fullStr | Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas |
| title_full_unstemmed | Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas |
| title_short | Distinct Chromosomal Profiles in Metastasizing and Non-Metastasizing Colorectal Carcinomas |
| title_sort | distinct chromosomal profiles in metastasizing and non metastasizing colorectal carcinomas |
| url | http://dx.doi.org/10.1155/2006/529190 |
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