Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy
Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease cont...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2017/1602039 |
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| author | Brigitta Dombai István Ivancsó András Bikov Dóra Oroszi Anikó Bohács Veronika Müller János Rigó Barna Vásárhelyi György Losonczy Lilla Tamási |
| author_facet | Brigitta Dombai István Ivancsó András Bikov Dóra Oroszi Anikó Bohács Veronika Müller János Rigó Barna Vásárhelyi György Losonczy Lilla Tamási |
| author_sort | Brigitta Dombai |
| collection | DOAJ |
| description | Asthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483–2.701] versus 2.075 [1.680–2.331] ng/mL, p=0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439–4.015] ng/ml, p=0.003 versus HNP) and asthmatic (AP: 2.693 [1.581–3.620] ng/ml) patients; thus the pregnant groups did not differ (p=0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59–116.3] versus 108.8 [97.94–115.3] µg/mL, p=0.8730) and the level was lower in HP (98.80 [84.26–105.5] µg/mL, p=0.0344 versus HNP). In contrast, the level was higher in AP (111.7 [98.84–125.6] µg/mL, p=0.0091 versus HP). In ANP, a positive correlation of PEF (r=0.3405; p=0.0221) and a negative correlation of Raw (r=-0.3723; p=0.0128) to clusterin level were detected. Circulating osteopontin level increases in pregnancy regardless of concomitant well-controlled asthma, indicating its gestational role. Clusterin level decreases in healthy but not in asthmatic pregnancy and correlates directly with lung function. |
| format | Article |
| id | doaj-art-eaa5047a58774caf8b7604ff7ca82c93 |
| institution | Kabale University |
| issn | 1198-2241 1916-7245 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-eaa5047a58774caf8b7604ff7ca82c932025-02-03T01:00:32ZengWileyCanadian Respiratory Journal1198-22411916-72452017-01-01201710.1155/2017/16020391602039Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic PregnancyBrigitta Dombai0István Ivancsó1András Bikov2Dóra Oroszi3Anikó Bohács4Veronika Müller5János Rigó6Barna Vásárhelyi7György Losonczy8Lilla Tamási9Department of Pulmonology, Semmelweis University, Budapest, HungaryKlinik für Anästhesie, Kantonsspital Aarau, Aarau, SwitzerlandDepartment of Pulmonology, Semmelweis University, Budapest, HungaryDepartment of Pulmonology, Semmelweis University, Budapest, HungaryDepartment of Pulmonology, Semmelweis University, Budapest, HungaryDepartment of Pulmonology, Semmelweis University, Budapest, Hungary1st Department of Obstetrics and Gynecology, Semmelweis University, Budapest, HungaryDepartment of Laboratory Medicine, Semmelweis University, Budapest, HungaryDepartment of Pulmonology, Semmelweis University, Budapest, HungaryDepartment of Pulmonology, Semmelweis University, Budapest, HungaryAsthma in pregnancy poses a risk of adverse outcomes. Osteopontin and clusterin emerged as asthma biomarkers; however, their circulating levels during pregnancy are unknown yet. This cross-sectional study investigated peripheral osteopontin and clusterin levels and their relationship to disease control in 26 asthmatic pregnant (AP), 22 asthmatic nonpregnant (ANP), and 25 healthy pregnant (HP) women and 12 healthy controls (HNP). Osteopontin levels of ANP and HNP were similar (2.142 [1.483–2.701] versus 2.075 [1.680–2.331] ng/mL, p=0.7331). Pregnancy caused a marked elevation in both healthy (HP: 3.037 [2.439–4.015] ng/ml, p=0.003 versus HNP) and asthmatic (AP: 2.693 [1.581–3.620] ng/ml) patients; thus the pregnant groups did not differ (p=0.3541). Circulating clusterin levels were comparable in ANP and HNP (109.2 [95.59–116.3] versus 108.8 [97.94–115.3] µg/mL, p=0.8730) and the level was lower in HP (98.80 [84.26–105.5] µg/mL, p=0.0344 versus HNP). In contrast, the level was higher in AP (111.7 [98.84–125.6] µg/mL, p=0.0091 versus HP). In ANP, a positive correlation of PEF (r=0.3405; p=0.0221) and a negative correlation of Raw (r=-0.3723; p=0.0128) to clusterin level were detected. Circulating osteopontin level increases in pregnancy regardless of concomitant well-controlled asthma, indicating its gestational role. Clusterin level decreases in healthy but not in asthmatic pregnancy and correlates directly with lung function.http://dx.doi.org/10.1155/2017/1602039 |
| spellingShingle | Brigitta Dombai István Ivancsó András Bikov Dóra Oroszi Anikó Bohács Veronika Müller János Rigó Barna Vásárhelyi György Losonczy Lilla Tamási Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy Canadian Respiratory Journal |
| title | Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy |
| title_full | Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy |
| title_fullStr | Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy |
| title_full_unstemmed | Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy |
| title_short | Circulating Clusterin and Osteopontin Levels in Asthma and Asthmatic Pregnancy |
| title_sort | circulating clusterin and osteopontin levels in asthma and asthmatic pregnancy |
| url | http://dx.doi.org/10.1155/2017/1602039 |
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