MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer
Background. Many researches revealed that microRNAs (miRNAs) function as potential oncogene or tumor suppressor gene. As an antioncogene, miR-877-5p was reduced in many tumors. Objective. This research aimed to explore the biological role and mechanisms of miR-877-5p, which may help patients with no...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
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| Series: | Canadian Respiratory Journal |
| Online Access: | http://dx.doi.org/10.1155/2022/4256172 |
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| _version_ | 1832554978857713664 |
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| author | Zhiguang Liu Xinlian Wang Liqiang Cao Xiaowei Yin Qian Zhang Lan Wang |
| author_facet | Zhiguang Liu Xinlian Wang Liqiang Cao Xiaowei Yin Qian Zhang Lan Wang |
| author_sort | Zhiguang Liu |
| collection | DOAJ |
| description | Background. Many researches revealed that microRNAs (miRNAs) function as potential oncogene or tumor suppressor gene. As an antioncogene, miR-877-5p was reduced in many tumors. Objective. This research aimed to explore the biological role and mechanisms of miR-877-5p, which may help patients with non-small-cell lung cancer (NSCLC) find effective therapeutic targets. Methods. The downstream targets of miR-877-5p were predicted by Bioinformatics software. RT-qPCR and western blot were employed to analyze the gene levels. The impacts of miR-877-5p and FOXM1 were assessed by cell function experiments. Results. The miR-877-5p was reduced in NSCLC. In addition to this, it also inhibited cell progression of NSCLC cells in vitro. Moreover, the upregulation of FOXM1 expression restored the inhibitory effect of enhancement of miR-877-5p. Conclusions. Taken together, miR-877-5p inhibited cell progression by directly targeting FOXM1, which may provide potential biomarkers for targeted therapy of NSCLC. |
| format | Article |
| id | doaj-art-eaa36dad0d4d40768323d8d3bc16b46c |
| institution | Kabale University |
| issn | 1916-7245 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Respiratory Journal |
| spelling | doaj-art-eaa36dad0d4d40768323d8d3bc16b46c2025-02-03T05:49:58ZengWileyCanadian Respiratory Journal1916-72452022-01-01202210.1155/2022/4256172MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung CancerZhiguang Liu0Xinlian Wang1Liqiang Cao2Xiaowei Yin3Qian Zhang4Lan Wang5Department of Respiratory and Critical Care MedicineDepartment of Thoracic SurgeryDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineDepartment of Respiratory and Critical Care MedicineBackground. Many researches revealed that microRNAs (miRNAs) function as potential oncogene or tumor suppressor gene. As an antioncogene, miR-877-5p was reduced in many tumors. Objective. This research aimed to explore the biological role and mechanisms of miR-877-5p, which may help patients with non-small-cell lung cancer (NSCLC) find effective therapeutic targets. Methods. The downstream targets of miR-877-5p were predicted by Bioinformatics software. RT-qPCR and western blot were employed to analyze the gene levels. The impacts of miR-877-5p and FOXM1 were assessed by cell function experiments. Results. The miR-877-5p was reduced in NSCLC. In addition to this, it also inhibited cell progression of NSCLC cells in vitro. Moreover, the upregulation of FOXM1 expression restored the inhibitory effect of enhancement of miR-877-5p. Conclusions. Taken together, miR-877-5p inhibited cell progression by directly targeting FOXM1, which may provide potential biomarkers for targeted therapy of NSCLC.http://dx.doi.org/10.1155/2022/4256172 |
| spellingShingle | Zhiguang Liu Xinlian Wang Liqiang Cao Xiaowei Yin Qian Zhang Lan Wang MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer Canadian Respiratory Journal |
| title | MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer |
| title_full | MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer |
| title_fullStr | MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer |
| title_full_unstemmed | MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer |
| title_short | MicroRNA-877-5p Inhibits Cell Progression by Targeting FOXM1 in Lung Cancer |
| title_sort | microrna 877 5p inhibits cell progression by targeting foxm1 in lung cancer |
| url | http://dx.doi.org/10.1155/2022/4256172 |
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