Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review
Typhoid fever is one of the few bacterial infections in humans where bone marrow evaluation is routinely recommended. However, the morphological aspect of typhoid fever in bone marrow has been rarely described in the literature. We describe a 25-year-old male patient who presented with prolonged fev...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2015/628028 |
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| author | Kavitha Muniraj Somanath Padhi Manjiri Phansalkar Periyasami Sivakumar Renu G’Boy Varghese Reba Kanungo |
| author_facet | Kavitha Muniraj Somanath Padhi Manjiri Phansalkar Periyasami Sivakumar Renu G’Boy Varghese Reba Kanungo |
| author_sort | Kavitha Muniraj |
| collection | DOAJ |
| description | Typhoid fever is one of the few bacterial infections in humans where bone marrow evaluation is routinely recommended. However, the morphological aspect of typhoid fever in bone marrow has been rarely described in the literature. We describe a 25-year-old male patient who presented with prolonged fever suspected to be of tubercular etiology. Bone marrow examination showed well-formed histiocytic and epithelioid granulomas and erythrophagocytosis; and the bone marrow aspirate culture grew Salmonella typhi A. In view of potential clinical implications, typhoid fever should be considered as a differential diagnosis to tuberculosis in the evaluation of prolonged fever; especially in high prevalent areas. We suggest that erythrophagocytosis may serve as a morphological marker in typhoid granulomas in the bone marrow; and bone marrow culture should be submitted in every suspected case for appropriate patient management. |
| format | Article |
| id | doaj-art-ea9a1cfea85d4b24a8c5e47f497810b1 |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-ea9a1cfea85d4b24a8c5e47f497810b12025-02-03T01:03:15ZengWileyCase Reports in Infectious Diseases2090-66252090-66332015-01-01201510.1155/2015/628028628028Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature ReviewKavitha Muniraj0Somanath Padhi1Manjiri Phansalkar2Periyasami Sivakumar3Renu G’Boy Varghese4Reba Kanungo5Department of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, IndiaDepartment of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, IndiaDepartment of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, IndiaDepartment of General Medicine, Pondicherry Institute of Medical Sciences, Puducherry 605014, IndiaDepartment of Pathology, Pondicherry Institute of Medical Sciences, Puducherry 605014, IndiaDepartment of Microbiology, Pondicherry Institute of Medical Sciences, Puducherry 605014, IndiaTyphoid fever is one of the few bacterial infections in humans where bone marrow evaluation is routinely recommended. However, the morphological aspect of typhoid fever in bone marrow has been rarely described in the literature. We describe a 25-year-old male patient who presented with prolonged fever suspected to be of tubercular etiology. Bone marrow examination showed well-formed histiocytic and epithelioid granulomas and erythrophagocytosis; and the bone marrow aspirate culture grew Salmonella typhi A. In view of potential clinical implications, typhoid fever should be considered as a differential diagnosis to tuberculosis in the evaluation of prolonged fever; especially in high prevalent areas. We suggest that erythrophagocytosis may serve as a morphological marker in typhoid granulomas in the bone marrow; and bone marrow culture should be submitted in every suspected case for appropriate patient management.http://dx.doi.org/10.1155/2015/628028 |
| spellingShingle | Kavitha Muniraj Somanath Padhi Manjiri Phansalkar Periyasami Sivakumar Renu G’Boy Varghese Reba Kanungo Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review Case Reports in Infectious Diseases |
| title | Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review |
| title_full | Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review |
| title_fullStr | Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review |
| title_full_unstemmed | Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review |
| title_short | Bone Marrow Granuloma in Typhoid Fever: A Morphological Approach and Literature Review |
| title_sort | bone marrow granuloma in typhoid fever a morphological approach and literature review |
| url | http://dx.doi.org/10.1155/2015/628028 |
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