The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves
<p><strong>Aim:</strong> Endototoxin is known to be an important mediator of gram negative bacterial sepsis. Endotoxemia is associated with high mortality rates in neonatal calves. Therefore, a safe and effective treatment for endotoxemia in calves is needed<br />in order to...
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Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
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| author | Enes Akyüz Alparslan Coşkun İsmail Şen |
| author_facet | Enes Akyüz Alparslan Coşkun İsmail Şen |
| author_sort | Enes Akyüz |
| collection | DOAJ |
| description | <p><strong>Aim:</strong> Endototoxin is known to be an important mediator of gram negative bacterial sepsis. Endotoxemia is associated with high mortality rates in neonatal calves. Therefore, a safe and effective treatment for endotoxemia in calves is needed<br />in order to address this common and potentially fatal condition. The primary aim of the study is to determine the effects of NaCl on the clinic, hematologic and hemodynamic parameters of calves.</p>
<p><strong>Materials and Methods:</strong> Twelve healthy calves, aged between 5 to 15 days included into the study. Calves which included into the study randomly divided two groups as lypopplisaccharide (LPS) and Control groups: Group I(LPS): 0.9% NaCl (IV) was given to calves at 1th hour following of LPS administration (1 μg/kg, IV, 50 mL 0.9% NaCl/30 min). Group II (Control): Only 0.9% NaCl (IV, 50 mL/30 min) was given to calves. Blood samples were taken from vena Jugularis before LPS infusion at 0 h (base line) and after LPS infusion at 1, 2, 4, 6, 8, 12, 18, 24, 36, 48, 72, and 96 hours.</p>
<p><strong>Results:</strong> Following the LPS administration, increase in lactate levels and heart rate as well as decrease in systolic and mean arterial pressures were indicated the failure in circulatory system. However, administration of 0.9% NaCl was improved this parameters near the base line at within 8 and 12 hours of study period.</p>
<p><strong>Conclusion:</strong> It may be concluded that the use of 0.9% NaCl in treatment of the endotoxemia would be useful in neonatal calves.</p> |
| format | Article |
| id | doaj-art-ea96c5b711774d12adcfd149bf72245d |
| institution | Kabale University |
| issn | 1309-6958 2146-1953 |
| language | English |
| publisher | Selcuk University Press |
| record_format | Article |
| series | Eurasian Journal of Veterinary Sciences |
| spelling | doaj-art-ea96c5b711774d12adcfd149bf72245d2025-02-03T11:25:40ZengSelcuk University PressEurasian Journal of Veterinary Sciences1309-69582146-19533242462541139The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calvesEnes Akyüz0Alparslan Coşkun1İsmail Şen2Kafkas Üniversitesi, Veteriner Fakültesi, İç hastalıkları ABD, Kars, TürkiyeCumhuriyet Üniversitesi, Veteriner Fakültesi, İç Hastalıkları ABD, Sivas, TürkiyeSelçuk Üniversitesi, Veteriner Fakültesi, İç hastalıkları ABD, Konya, Türkiye<p><strong>Aim:</strong> Endototoxin is known to be an important mediator of gram negative bacterial sepsis. Endotoxemia is associated with high mortality rates in neonatal calves. Therefore, a safe and effective treatment for endotoxemia in calves is needed<br />in order to address this common and potentially fatal condition. The primary aim of the study is to determine the effects of NaCl on the clinic, hematologic and hemodynamic parameters of calves.</p> <p><strong>Materials and Methods:</strong> Twelve healthy calves, aged between 5 to 15 days included into the study. Calves which included into the study randomly divided two groups as lypopplisaccharide (LPS) and Control groups: Group I(LPS): 0.9% NaCl (IV) was given to calves at 1th hour following of LPS administration (1 μg/kg, IV, 50 mL 0.9% NaCl/30 min). Group II (Control): Only 0.9% NaCl (IV, 50 mL/30 min) was given to calves. Blood samples were taken from vena Jugularis before LPS infusion at 0 h (base line) and after LPS infusion at 1, 2, 4, 6, 8, 12, 18, 24, 36, 48, 72, and 96 hours.</p> <p><strong>Results:</strong> Following the LPS administration, increase in lactate levels and heart rate as well as decrease in systolic and mean arterial pressures were indicated the failure in circulatory system. However, administration of 0.9% NaCl was improved this parameters near the base line at within 8 and 12 hours of study period.</p> <p><strong>Conclusion:</strong> It may be concluded that the use of 0.9% NaCl in treatment of the endotoxemia would be useful in neonatal calves.</p>http://eurasianjvetsci.org/pdf.php3?id=1139calvesendotoxemiasepsis0.9% nacl |
| spellingShingle | Enes Akyüz Alparslan Coşkun İsmail Şen The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves Eurasian Journal of Veterinary Sciences calves endotoxemia sepsis 0.9% nacl |
| title | The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves |
| title_full | The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves |
| title_fullStr | The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves |
| title_full_unstemmed | The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves |
| title_short | The effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves |
| title_sort | effects of fluid resuscitation on the hemodynamic parameters of experimental induced endotoxemia in the neonatal calves |
| topic | calves endotoxemia sepsis 0.9% nacl |
| url | http://eurasianjvetsci.org/pdf.php3?id=1139 |
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