Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy
Aims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among ammonia, cerebral hemodynamics, and cognitive function. Methods. There were four groups: healthy controls (group 1), cirrhosis without HE (grou...
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| Main Authors: | , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2016/8485032 |
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| author | Yuqing Zhou Qian Dong Rong Zhang Shunfeng Zhou Linqiang Li Keran Cheng Rui Kong Qiang Yu Shizan Xu Jingjing Li Sainan Li Jiao Feng Liwei Wu Tong Liu Xiya Lu Kan Chen Yujing Xia Jie Lu Yingqun Zhou Chuanyong Guo |
| author_facet | Yuqing Zhou Qian Dong Rong Zhang Shunfeng Zhou Linqiang Li Keran Cheng Rui Kong Qiang Yu Shizan Xu Jingjing Li Sainan Li Jiao Feng Liwei Wu Tong Liu Xiya Lu Kan Chen Yujing Xia Jie Lu Yingqun Zhou Chuanyong Guo |
| author_sort | Yuqing Zhou |
| collection | DOAJ |
| description | Aims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among ammonia, cerebral hemodynamics, and cognitive function. Methods. There were four groups: healthy controls (group 1), cirrhosis without HE (group 2), cirrhosis with MHE (group 3), and cirrhosis with OHE (group 4). Ammonia and cerebral hemodynamics (by TCD) were assessed. Patients in group 3 were subsequently randomized to two subgroups: the control (group A) and the treated (group B, treated with lactulose for two months), and they were retested for ammonia and TCD after treatment. Results. Ammonia, Vm, Vd, PI, and RI were statistically different before treatment, and ammonia, PI, and RI levels paralleled the severity of HE (P<0.05). In group B, Vd increased and ammonia, PI, and RI declined following treatment (P<0.05), while there were no differences in group A (P>0.05). Correlations were found between ammonia and Vd, PI, RI, NCT-A, and DST and also found between Vd, PI, RI, and NCT-A and DST (P<0.05). Conclusions. This study revealed that cerebral hemodynamics were related to the severity of HE and cerebral autoregulation was impaired. There were tight correlations among ammonia, cerebral hemodynamics, and cognitive function, and, following treatment, cerebral hemodynamics improved. |
| format | Article |
| id | doaj-art-ea77d4976fba4ee88cfd9603044891de |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-ea77d4976fba4ee88cfd9603044891de2025-02-03T06:08:12ZengWileyGastroenterology Research and Practice1687-61211687-630X2016-01-01201610.1155/2016/84850328485032Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic EncephalopathyYuqing Zhou0Qian Dong1Rong Zhang2Shunfeng Zhou3Linqiang Li4Keran Cheng5Rui Kong6Qiang Yu7Shizan Xu8Jingjing Li9Sainan Li10Jiao Feng11Liwei Wu12Tong Liu13Xiya Lu14Kan Chen15Yujing Xia16Jie Lu17Yingqun Zhou18Chuanyong Guo19Department of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaThe Shanghai Tenth Hospital, School of Clinical Medicine of Nanjing Medical University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaDepartment of Gastroenterology, Shanghai Tenth People’s Hospital, School of Medicine, Tongji University, Shanghai 200072, ChinaAims. To investigate cerebral hemodynamics in cirrhotic patients with HE and to observe effects of treatment in cerebral hemodynamics and correlations among ammonia, cerebral hemodynamics, and cognitive function. Methods. There were four groups: healthy controls (group 1), cirrhosis without HE (group 2), cirrhosis with MHE (group 3), and cirrhosis with OHE (group 4). Ammonia and cerebral hemodynamics (by TCD) were assessed. Patients in group 3 were subsequently randomized to two subgroups: the control (group A) and the treated (group B, treated with lactulose for two months), and they were retested for ammonia and TCD after treatment. Results. Ammonia, Vm, Vd, PI, and RI were statistically different before treatment, and ammonia, PI, and RI levels paralleled the severity of HE (P<0.05). In group B, Vd increased and ammonia, PI, and RI declined following treatment (P<0.05), while there were no differences in group A (P>0.05). Correlations were found between ammonia and Vd, PI, RI, NCT-A, and DST and also found between Vd, PI, RI, and NCT-A and DST (P<0.05). Conclusions. This study revealed that cerebral hemodynamics were related to the severity of HE and cerebral autoregulation was impaired. There were tight correlations among ammonia, cerebral hemodynamics, and cognitive function, and, following treatment, cerebral hemodynamics improved.http://dx.doi.org/10.1155/2016/8485032 |
| spellingShingle | Yuqing Zhou Qian Dong Rong Zhang Shunfeng Zhou Linqiang Li Keran Cheng Rui Kong Qiang Yu Shizan Xu Jingjing Li Sainan Li Jiao Feng Liwei Wu Tong Liu Xiya Lu Kan Chen Yujing Xia Jie Lu Yingqun Zhou Chuanyong Guo Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy Gastroenterology Research and Practice |
| title | Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy |
| title_full | Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy |
| title_fullStr | Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy |
| title_full_unstemmed | Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy |
| title_short | Cerebral Hemodynamics and Cognitive Function in Cirrhotic Patients with Hepatic Encephalopathy |
| title_sort | cerebral hemodynamics and cognitive function in cirrhotic patients with hepatic encephalopathy |
| url | http://dx.doi.org/10.1155/2016/8485032 |
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