GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma
Gastric cancer is one of the cancers with the highest incidence in the world. Gamma-glutamyltransferase 5 (GGT5) is expressed in different cancers and its role in cancers remains unclear. In this study, we aimed to evaluate the value of GGT5 in stomach adenocarcinoma (STAD). In TCGA, patients with h...
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Wiley
2022-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2022/9983351 |
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| author | Yong Huang HaiLang Zhou Junwei Zou Dong Wang |
| author_facet | Yong Huang HaiLang Zhou Junwei Zou Dong Wang |
| author_sort | Yong Huang |
| collection | DOAJ |
| description | Gastric cancer is one of the cancers with the highest incidence in the world. Gamma-glutamyltransferase 5 (GGT5) is expressed in different cancers and its role in cancers remains unclear. In this study, we aimed to evaluate the value of GGT5 in stomach adenocarcinoma (STAD). In TCGA, patients with high GGT5 expression had poor overall survival (P=0.006). Based on GSE62254, high expression of GGT5 was associated with poor OS (P=0.014) and PFS (P=0.042). The same result was observed in GSE14210. We further discovered that GGT5 expression was associated with stage, grade, and T stage. Further prognostic analysis of GGT5 showed that GGT5 was associated with prognosis in both univariate analysis (P=0.032) and multivariate analysis (P=0.029). We used gene set enrichment analysis (GSEA) to explore the possible mechanism of GGT5. GSEA suggests that overexpression of GGT5 may be involved in leukocyte transendothelial migration, JAK-STAT signaling pathway, MAPK signaling pathway, and melanoma. The high-expression GGT5 group had higher concentrations of M2 macrophages, T cell regulators, and monocytes, but the contents of plasma cells and M1 macrophages were higher in the low-expression GGT5 group. The results showed that the ESTIMATEScore, ImmuneScore, and StromalScore of the high-expression GGT5 group were higher than those of the low-expression GGT5 group. PD1 and CTLA4 expression levels were higher in the high-expression GGT5 group. The high-expression GGT5 group may be more effective for immunotherapy. These results suggested that GGT5 could be a potential prognostic molecular predictor in STAD. |
| format | Article |
| id | doaj-art-ea630186b63a4987be0de2e7a6918999 |
| institution | Kabale University |
| issn | 2291-2797 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
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| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-ea630186b63a4987be0de2e7a69189992025-02-03T01:20:11ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27972022-01-01202210.1155/2022/9983351GGT5 Is an Independent Prognostic Biomarker in Stomach AdenocarcinomaYong Huang0HaiLang Zhou1Junwei Zou2Dong Wang3Department of Gastrointestinal SurgeryDepartment of GastroenterologyDepartment of Gastrointestinal SurgeryDepartment of Hepatobiliary SurgeryGastric cancer is one of the cancers with the highest incidence in the world. Gamma-glutamyltransferase 5 (GGT5) is expressed in different cancers and its role in cancers remains unclear. In this study, we aimed to evaluate the value of GGT5 in stomach adenocarcinoma (STAD). In TCGA, patients with high GGT5 expression had poor overall survival (P=0.006). Based on GSE62254, high expression of GGT5 was associated with poor OS (P=0.014) and PFS (P=0.042). The same result was observed in GSE14210. We further discovered that GGT5 expression was associated with stage, grade, and T stage. Further prognostic analysis of GGT5 showed that GGT5 was associated with prognosis in both univariate analysis (P=0.032) and multivariate analysis (P=0.029). We used gene set enrichment analysis (GSEA) to explore the possible mechanism of GGT5. GSEA suggests that overexpression of GGT5 may be involved in leukocyte transendothelial migration, JAK-STAT signaling pathway, MAPK signaling pathway, and melanoma. The high-expression GGT5 group had higher concentrations of M2 macrophages, T cell regulators, and monocytes, but the contents of plasma cells and M1 macrophages were higher in the low-expression GGT5 group. The results showed that the ESTIMATEScore, ImmuneScore, and StromalScore of the high-expression GGT5 group were higher than those of the low-expression GGT5 group. PD1 and CTLA4 expression levels were higher in the high-expression GGT5 group. The high-expression GGT5 group may be more effective for immunotherapy. These results suggested that GGT5 could be a potential prognostic molecular predictor in STAD.http://dx.doi.org/10.1155/2022/9983351 |
| spellingShingle | Yong Huang HaiLang Zhou Junwei Zou Dong Wang GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma Canadian Journal of Gastroenterology and Hepatology |
| title | GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma |
| title_full | GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma |
| title_fullStr | GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma |
| title_full_unstemmed | GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma |
| title_short | GGT5 Is an Independent Prognostic Biomarker in Stomach Adenocarcinoma |
| title_sort | ggt5 is an independent prognostic biomarker in stomach adenocarcinoma |
| url | http://dx.doi.org/10.1155/2022/9983351 |
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