Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature
To investigate the clinicopathological characteristics and possible causes of solitary necrotic nodule of the liver (SNN), two cases of SNN of the liver were studied with clinicopathological data, immunohistochemistry, and histochemistry staining. The patients had no specific symptoms, with negative...
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| Language: | English |
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Wiley
2011-01-01
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| Series: | Case Reports in Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2011/845406 |
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| author | Hong-Qun Wang Zheng-Sheng Wu Dao-Wang Li |
| author_facet | Hong-Qun Wang Zheng-Sheng Wu Dao-Wang Li |
| author_sort | Hong-Qun Wang |
| collection | DOAJ |
| description | To investigate the clinicopathological characteristics and possible causes of solitary necrotic nodule of the liver (SNN), two cases of SNN of the liver were studied with clinicopathological data, immunohistochemistry, and histochemistry staining. The patients had no specific symptoms, with negative results for the serum tumor markers. CT and ultrasound all showed low-density lesion. Morphologically, there was isolate, single necrosis tubercle of the liver. It was composed of a central necrotic core and a peripheral fibrotic capsule with inflammatory cells, including histiocytes, plasma cells, lymphocytes, and so forth. The staining result of PAS, acid-fast, and iron was all negative, and AG + VG staining showed that the outline of reticular fibers and collagen was intact. Vimtin was positive for necrotic tissue and surrounding fibrous tissue. CD34 and CD68 was both positive for case 1. CK was negative in case 2 but positive for a few residual cells in case 1. SNN of the liver is a rare nonmalignant disease with a good prognosis. Hemangioma and fatty liver might be ones of the causes of SNN. |
| format | Article |
| id | doaj-art-ea586f296df448dc8d8297ffbda01598 |
| institution | Kabale University |
| issn | 2090-6587 2090-6595 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hepatology |
| spelling | doaj-art-ea586f296df448dc8d8297ffbda015982025-02-03T06:04:55ZengWileyCase Reports in Hepatology2090-65872090-65952011-01-01201110.1155/2011/845406845406Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the LiteratureHong-Qun Wang0Zheng-Sheng Wu1Dao-Wang Li2Department of Pathology, The Third People's Hospital, Hefei 230022, ChinaDepartment of Pathology, Anhui Medical University, 81 Meishan Road, Hefei 230032, Anhui Province, ChinaDepartment of Urology, The 105th Hospital of People's Liberation Army, Hefei 230011, ChinaTo investigate the clinicopathological characteristics and possible causes of solitary necrotic nodule of the liver (SNN), two cases of SNN of the liver were studied with clinicopathological data, immunohistochemistry, and histochemistry staining. The patients had no specific symptoms, with negative results for the serum tumor markers. CT and ultrasound all showed low-density lesion. Morphologically, there was isolate, single necrosis tubercle of the liver. It was composed of a central necrotic core and a peripheral fibrotic capsule with inflammatory cells, including histiocytes, plasma cells, lymphocytes, and so forth. The staining result of PAS, acid-fast, and iron was all negative, and AG + VG staining showed that the outline of reticular fibers and collagen was intact. Vimtin was positive for necrotic tissue and surrounding fibrous tissue. CD34 and CD68 was both positive for case 1. CK was negative in case 2 but positive for a few residual cells in case 1. SNN of the liver is a rare nonmalignant disease with a good prognosis. Hemangioma and fatty liver might be ones of the causes of SNN.http://dx.doi.org/10.1155/2011/845406 |
| spellingShingle | Hong-Qun Wang Zheng-Sheng Wu Dao-Wang Li Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature Case Reports in Hepatology |
| title | Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature |
| title_full | Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature |
| title_fullStr | Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature |
| title_full_unstemmed | Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature |
| title_short | Solitary Necrotic Nodule of the Liver: A Report of Two Cases and Review of the Literature |
| title_sort | solitary necrotic nodule of the liver a report of two cases and review of the literature |
| url | http://dx.doi.org/10.1155/2011/845406 |
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