Clinical Impact of CD19 Expression Assessed by Quantitative PCR in Lymphoma Patients Undergoing CAR‐T Therapy

Clinical Impact of CD19 Expression Assessed by Quantitative PCR in Lymphoma Patients Undergoing CAR‐T Therapy

ABSTRACT Introduction Current guidelines do not mandate CD19 tumor expression assessment before chimeric antigen receptor T‐cell (CAR‐T) therapy in large B‐cell lymphoma (LBCL) patients due to limitations of immunohistochemistry (IHC) or flow cytometry. Quantitative polymerase chain reaction (qPCR)...

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Main Authors: Rafael Hernani, Laura Ventura, Begoña Heras, Alicia Serrano, Marcos Rivada, Carolina Martínez‐Ciarpaglini, Ana Benzaquén, Blanca Ferrer‐Lores, Ariadna Pérez, José Luis Piñana, Juan Carlos Hernández‐Boluda, Ignacio Arroyo, Paula Amat, Irene Pastor‐Galán, María José Remigia, Rosa Goterris, Montse Gómez, Anabel Teruel, Ana Saus, Consejo Ortí, María José Terol, Antonio Ferrández‐Izquierdo, Carlos Solano
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:eJHaem
Subjects:
CAR‐T therapy
large B‐cell lymphoma
CD19 tumor expression
quantitative PCR
Online Access:https://doi.org/10.1002/jha2.70015
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