Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway

Saikosaponin A induces cellular senescence in triple-negative breast cancer by inhibiting the PI3K/Akt signalling pathway

BackgroundBreast cancer has now become the most prevalent cancer worldwide. Existing therapeutic agents are generally accompanied by significant side effects. Here, we highlight Saikosaponin A (SSA), a promising natural metabolite characterized by low toxicity, demonstrating significant efficacy aga...

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Bibliographic Details
Main Authors: Yingchao Wu, Liushan Chen, Dajin Pi, Jiaqi Cui, Yuqi Liang, Peng Wu, Mingzi Ouyang, Qian Zuo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
saikosaponin a
breast cancer
network analysis
cellular senescence
PI3K/Akt signaling pathway
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1532579/full
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