Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone
Amiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of ventricular tachyarrhythmias making it irreplaceable in certain group of patients. We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone which r...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2016-01-01
|
| Series: | Case Reports in Critical Care |
| Online Access: | http://dx.doi.org/10.1155/2016/5232804 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562296604327936 |
|---|---|
| author | Robin Paudel Prerna Dogra Saurav Suman Saurav Acharya Jyoti Matta |
| author_facet | Robin Paudel Prerna Dogra Saurav Suman Saurav Acharya Jyoti Matta |
| author_sort | Robin Paudel |
| collection | DOAJ |
| description | Amiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of ventricular tachyarrhythmias making it irreplaceable in certain group of patients. We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone which resolved after stopping the medication. The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. In this case review, we discuss the hyperacute drug toxicity caused by IV amiodarone being a distinctly different entity compared to the adverse effects shown by oral amiodarone and support the suggestion that oral amiodarone can be safely administered even in patients who manifest acute hepatitis with the IV form. |
| format | Article |
| id | doaj-art-ea2e6136313f48fda5b5f0672ca98000 |
| institution | Kabale University |
| issn | 2090-6420 2090-6439 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Critical Care |
| spelling | doaj-art-ea2e6136313f48fda5b5f0672ca980002025-02-03T01:23:06ZengWileyCase Reports in Critical Care2090-64202090-64392016-01-01201610.1155/2016/52328045232804Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of AmiodaroneRobin Paudel0Prerna Dogra1Saurav Suman2Saurav Acharya3Jyoti Matta4Department of Internal Medicine, University of Kentucky, Lexington, KY, USADepartment of Internal Medicine, University of Kentucky, Lexington, KY, USADepartment of Internal Medicine, University of Kentucky, Lexington, KY, USADepartment of Internal Medicine, Jersey City Medical Center, Jersey City, NJ, USADepartment of Internal Medicine, Jersey City Medical Center, Jersey City, NJ, USAAmiodarone is an antiarrhythmic drug which is highly effective against a wide spectrum of ventricular tachyarrhythmias making it irreplaceable in certain group of patients. We report an unusual case of acute liver and renal failure within 24 hours of initiation of intravenous (IV) amiodarone which resolved after stopping the medication. The mechanism of acute liver and renal toxicity is not clearly known but is believed to be secondary to amiodarone induced (relative) hypotension, idiosyncratic reaction to the drug, and toxicity of the vector that carries the medication, polysorbate-80. In this case review, we discuss the hyperacute drug toxicity caused by IV amiodarone being a distinctly different entity compared to the adverse effects shown by oral amiodarone and support the suggestion that oral amiodarone can be safely administered even in patients who manifest acute hepatitis with the IV form.http://dx.doi.org/10.1155/2016/5232804 |
| spellingShingle | Robin Paudel Prerna Dogra Saurav Suman Saurav Acharya Jyoti Matta Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone Case Reports in Critical Care |
| title | Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone |
| title_full | Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone |
| title_fullStr | Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone |
| title_full_unstemmed | Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone |
| title_short | Acute Liver and Renal Failure: A Rare Adverse Effect Exclusive to Intravenous form of Amiodarone |
| title_sort | acute liver and renal failure a rare adverse effect exclusive to intravenous form of amiodarone |
| url | http://dx.doi.org/10.1155/2016/5232804 |
| work_keys_str_mv | AT robinpaudel acuteliverandrenalfailurearareadverseeffectexclusivetointravenousformofamiodarone AT prernadogra acuteliverandrenalfailurearareadverseeffectexclusivetointravenousformofamiodarone AT sauravsuman acuteliverandrenalfailurearareadverseeffectexclusivetointravenousformofamiodarone AT sauravacharya acuteliverandrenalfailurearareadverseeffectexclusivetointravenousformofamiodarone AT jyotimatta acuteliverandrenalfailurearareadverseeffectexclusivetointravenousformofamiodarone |