Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review
In the elderly, cerebral amyloid angiopathy (CAA) is the most common cause for intracranial lobar hemorrhages. CAA is caused by the accumulation of amyloid-β fibrils in cortical and leptomeningeal vessels. In 2022, the Boston Criteria 2.0 became the new diagnostic standard for CAA, following the Mod...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2024-11-01
|
| Series: | Biomolecules |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2218-273X/14/11/1459 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850217519189590016 |
|---|---|
| author | Ulf Jensen-Kondering Katharina Heß Alexander Neumann Nils G. Margraf |
| author_facet | Ulf Jensen-Kondering Katharina Heß Alexander Neumann Nils G. Margraf |
| author_sort | Ulf Jensen-Kondering |
| collection | DOAJ |
| description | In the elderly, cerebral amyloid angiopathy (CAA) is the most common cause for intracranial lobar hemorrhages. CAA is caused by the accumulation of amyloid-β fibrils in cortical and leptomeningeal vessels. In 2022, the Boston Criteria 2.0 became the new diagnostic standard for CAA, following the Modified Boston Criteria of 2010. The diagnostic criteria are a composite of clinical, imaging and histopathological findings. In the latest version of the Boston Criteria, neuroradiological imaging findings were even expanded compared to the previous version. Crucially, the correct application of the diagnostic criteria is necessary to avoid over- and underdiagnosis. The aim of this review is to demonstrate the diagnostic criteria for CAA with an emphasis on typical imaging findings which are part of the Boston Criteria 2.0 and other imaging findings suggestive of CAA. |
| format | Article |
| id | doaj-art-ea2a4cc7a96444ed9dda6ad0780e8889 |
| institution | OA Journals |
| issn | 2218-273X |
| language | English |
| publishDate | 2024-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomolecules |
| spelling | doaj-art-ea2a4cc7a96444ed9dda6ad0780e88892025-08-20T02:08:02ZengMDPI AGBiomolecules2218-273X2024-11-011411145910.3390/biom14111459Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging ReviewUlf Jensen-Kondering0Katharina Heß1Alexander Neumann2Nils G. Margraf3Department of Neuroradiology, University Medical Centre Schleswig-Holstein, Campus Lübeck, 23538 Lübeck, GermanyDepartment of Pathology, University Medical Centre Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyDepartment of Neuroradiology, University Medical Centre Schleswig-Holstein, Campus Lübeck, 23538 Lübeck, GermanyDepartment of Neurology, University Medical Centre Schleswig-Holstein, Campus Kiel, 24105 Kiel, GermanyIn the elderly, cerebral amyloid angiopathy (CAA) is the most common cause for intracranial lobar hemorrhages. CAA is caused by the accumulation of amyloid-β fibrils in cortical and leptomeningeal vessels. In 2022, the Boston Criteria 2.0 became the new diagnostic standard for CAA, following the Modified Boston Criteria of 2010. The diagnostic criteria are a composite of clinical, imaging and histopathological findings. In the latest version of the Boston Criteria, neuroradiological imaging findings were even expanded compared to the previous version. Crucially, the correct application of the diagnostic criteria is necessary to avoid over- and underdiagnosis. The aim of this review is to demonstrate the diagnostic criteria for CAA with an emphasis on typical imaging findings which are part of the Boston Criteria 2.0 and other imaging findings suggestive of CAA.https://www.mdpi.com/2218-273X/14/11/1459cerebral amyloid angiopathyBoston CriterianeuroimagingMRICT |
| spellingShingle | Ulf Jensen-Kondering Katharina Heß Alexander Neumann Nils G. Margraf Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review Biomolecules cerebral amyloid angiopathy Boston Criteria neuroimaging MRI CT |
| title | Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review |
| title_full | Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review |
| title_fullStr | Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review |
| title_full_unstemmed | Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review |
| title_short | Neuroradiological Findings in Cerebral Amyloid Angiopathy with a Particular Consideration of the Boston Criteria 2.0: An Imaging Review |
| title_sort | neuroradiological findings in cerebral amyloid angiopathy with a particular consideration of the boston criteria 2 0 an imaging review |
| topic | cerebral amyloid angiopathy Boston Criteria neuroimaging MRI CT |
| url | https://www.mdpi.com/2218-273X/14/11/1459 |
| work_keys_str_mv | AT ulfjensenkondering neuroradiologicalfindingsincerebralamyloidangiopathywithaparticularconsiderationofthebostoncriteria20animagingreview AT katharinaheß neuroradiologicalfindingsincerebralamyloidangiopathywithaparticularconsiderationofthebostoncriteria20animagingreview AT alexanderneumann neuroradiologicalfindingsincerebralamyloidangiopathywithaparticularconsiderationofthebostoncriteria20animagingreview AT nilsgmargraf neuroradiologicalfindingsincerebralamyloidangiopathywithaparticularconsiderationofthebostoncriteria20animagingreview |