Hyperuricemia: An Early Marker for Severity of Illness in Sepsis
Background. Uric acid can acutely activate various inflammatory transcription factors. Since high levels of oxyradicals and lower antioxidant levels in septic patients are believed to result in multiorgan failure, uric acid levels could be used as a marker of oxidative stress and poor prognosis in p...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | International Journal of Nephrology |
| Online Access: | http://dx.doi.org/10.1155/2015/301021 |
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| author | Sana R. Akbar Dustin M. Long Kashif Hussain Ahmad Alhajhusain Umair S. Ahmed Hafiz I. Iqbal Ailia W. Ali Rachel Leonard Cheryl Dalton |
| author_facet | Sana R. Akbar Dustin M. Long Kashif Hussain Ahmad Alhajhusain Umair S. Ahmed Hafiz I. Iqbal Ailia W. Ali Rachel Leonard Cheryl Dalton |
| author_sort | Sana R. Akbar |
| collection | DOAJ |
| description | Background. Uric acid can acutely activate various inflammatory transcription factors. Since high levels of oxyradicals and lower antioxidant levels in septic patients are believed to result in multiorgan failure, uric acid levels could be used as a marker of oxidative stress and poor prognosis in patients with sepsis. Design. We conducted a prospective cohort study on Medical Intensive Care Unit (MICU) patients and hypothesized that elevated uric acid in patients with sepsis is predictive of greater morbidity. The primary end point was the correlation between hyperuricemia and the morbidity rate. Secondary end points were Acute Kidney Injury (AKI), mortality, Acute Respiratory Distress Syndrome (ARDS), and duration of stay. Results. We enrolled 144 patients. 54 (37.5%) had the primary end point of hyperuricemia. The overall morbidity rate was 85.2%. The probability of having hyperuricemia along with AKI was 68.5% and without AKI was 31.5%. Meanwhile the probability of having a uric acid value <7 mg/dL along with AKI was 18.9% and without AKI was 81.1% (p value < 0.0001). Conclusion. We report that elevated uric acid levels on arrival to the MICU in patients with sepsis are associated with poor prognosis. These patients are at an increased risk for AKI and ARDS. |
| format | Article |
| id | doaj-art-ea25d4dbcc55477d8d473a34029572fc |
| institution | Kabale University |
| issn | 2090-214X 2090-2158 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Nephrology |
| spelling | doaj-art-ea25d4dbcc55477d8d473a34029572fc2025-02-03T01:31:37ZengWileyInternational Journal of Nephrology2090-214X2090-21582015-01-01201510.1155/2015/301021301021Hyperuricemia: An Early Marker for Severity of Illness in SepsisSana R. Akbar0Dustin M. Long1Kashif Hussain2Ahmad Alhajhusain3Umair S. Ahmed4Hafiz I. Iqbal5Ailia W. Ali6Rachel Leonard7Cheryl Dalton8Division of Nephrology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADivision of Biostatistics, West Virginia University School of Medicine, Morgantown, WV, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADivision of Nephrology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADivision of Nephrology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADivision of Pulmonary and Critical Care Medicine, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADepartment of Medicine, West Virginia University School of Medicine, Morgantown, WV, USADivision of Nephrology, Department of Medicine, West Virginia University School of Medicine, Morgantown, WV, USABackground. Uric acid can acutely activate various inflammatory transcription factors. Since high levels of oxyradicals and lower antioxidant levels in septic patients are believed to result in multiorgan failure, uric acid levels could be used as a marker of oxidative stress and poor prognosis in patients with sepsis. Design. We conducted a prospective cohort study on Medical Intensive Care Unit (MICU) patients and hypothesized that elevated uric acid in patients with sepsis is predictive of greater morbidity. The primary end point was the correlation between hyperuricemia and the morbidity rate. Secondary end points were Acute Kidney Injury (AKI), mortality, Acute Respiratory Distress Syndrome (ARDS), and duration of stay. Results. We enrolled 144 patients. 54 (37.5%) had the primary end point of hyperuricemia. The overall morbidity rate was 85.2%. The probability of having hyperuricemia along with AKI was 68.5% and without AKI was 31.5%. Meanwhile the probability of having a uric acid value <7 mg/dL along with AKI was 18.9% and without AKI was 81.1% (p value < 0.0001). Conclusion. We report that elevated uric acid levels on arrival to the MICU in patients with sepsis are associated with poor prognosis. These patients are at an increased risk for AKI and ARDS.http://dx.doi.org/10.1155/2015/301021 |
| spellingShingle | Sana R. Akbar Dustin M. Long Kashif Hussain Ahmad Alhajhusain Umair S. Ahmed Hafiz I. Iqbal Ailia W. Ali Rachel Leonard Cheryl Dalton Hyperuricemia: An Early Marker for Severity of Illness in Sepsis International Journal of Nephrology |
| title | Hyperuricemia: An Early Marker for Severity of Illness in Sepsis |
| title_full | Hyperuricemia: An Early Marker for Severity of Illness in Sepsis |
| title_fullStr | Hyperuricemia: An Early Marker for Severity of Illness in Sepsis |
| title_full_unstemmed | Hyperuricemia: An Early Marker for Severity of Illness in Sepsis |
| title_short | Hyperuricemia: An Early Marker for Severity of Illness in Sepsis |
| title_sort | hyperuricemia an early marker for severity of illness in sepsis |
| url | http://dx.doi.org/10.1155/2015/301021 |
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