Association between type III collagen degradation and local tissue damage of a single joint
Objective: The development of disease-modifying drugs is limited by OA's heterogeneity and the challenge of defining clinical endpoints. Serological biomarkers are considered potential surrogate endpoints, but their contribution from single joints to systemic levels in OA patients is unclear. I...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2024-12-01
|
| Series: | Osteoarthritis and Cartilage Open |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665913124000943 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850066744011390976 |
|---|---|
| author | Christian S. Thudium Sten Rasmussen Morten A. Karsdal Anne-Christine Bay-Jensen |
| author_facet | Christian S. Thudium Sten Rasmussen Morten A. Karsdal Anne-Christine Bay-Jensen |
| author_sort | Christian S. Thudium |
| collection | DOAJ |
| description | Objective: The development of disease-modifying drugs is limited by OA's heterogeneity and the challenge of defining clinical endpoints. Serological biomarkers are considered potential surrogate endpoints, but their contribution from single joints to systemic levels in OA patients is unclear. In this exploratory study we longitudinally assessed systemic biomarker levels' response to tissue damage and healing before and after surgery in patients undergoing knee or hip joint replacement revision for aseptic failure. Patients with chronic pain associated with a prior hip or knee arthroplasty, but not receiving revision surgery were included as control. Method: The serological biomarker of MMP mediated type III collagen degradation C3M, associated with synovial tissue degradation, was measured at baseline before revision surgery, after revision surgery and at a 6-month follow-up in 48 patients with aseptic loosening of a knee or hip prosthesis and in 18 patients with chronic pain from a hip or knee prosthesis. Longitudinal changes in biomarkers were modeled using linear mixed models. Results: No differences between the aseptic loosening and chronic pain groups were observed at baseline. Revision surgery in the aseptic loosening group led to a swift increase in C3M, which normalized within 2–3 months. No changes in biomarker level were observed in chronic pain patients over three months. Conclusion: These findings suggest that tissue damage in a single joint significantly impacts systemic biomarker levels and underscores the relevance of systemic biomarkers in assessing local tissue remodeling. |
| format | Article |
| id | doaj-art-ea2442c807d1402bb80cfccc878e23d5 |
| institution | DOAJ |
| issn | 2665-9131 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Osteoarthritis and Cartilage Open |
| spelling | doaj-art-ea2442c807d1402bb80cfccc878e23d52025-08-20T02:48:39ZengElsevierOsteoarthritis and Cartilage Open2665-91312024-12-016410052710.1016/j.ocarto.2024.100527Association between type III collagen degradation and local tissue damage of a single jointChristian S. Thudium0Sten Rasmussen1Morten A. Karsdal2Anne-Christine Bay-Jensen3Nordic Bioscience A/S, Herlev, Denmark; Corresponding author.Department of Clinical Medicine, Aalborg University, DenmarkNordic Bioscience A/S, Herlev, DenmarkNordic Bioscience A/S, Herlev, DenmarkObjective: The development of disease-modifying drugs is limited by OA's heterogeneity and the challenge of defining clinical endpoints. Serological biomarkers are considered potential surrogate endpoints, but their contribution from single joints to systemic levels in OA patients is unclear. In this exploratory study we longitudinally assessed systemic biomarker levels' response to tissue damage and healing before and after surgery in patients undergoing knee or hip joint replacement revision for aseptic failure. Patients with chronic pain associated with a prior hip or knee arthroplasty, but not receiving revision surgery were included as control. Method: The serological biomarker of MMP mediated type III collagen degradation C3M, associated with synovial tissue degradation, was measured at baseline before revision surgery, after revision surgery and at a 6-month follow-up in 48 patients with aseptic loosening of a knee or hip prosthesis and in 18 patients with chronic pain from a hip or knee prosthesis. Longitudinal changes in biomarkers were modeled using linear mixed models. Results: No differences between the aseptic loosening and chronic pain groups were observed at baseline. Revision surgery in the aseptic loosening group led to a swift increase in C3M, which normalized within 2–3 months. No changes in biomarker level were observed in chronic pain patients over three months. Conclusion: These findings suggest that tissue damage in a single joint significantly impacts systemic biomarker levels and underscores the relevance of systemic biomarkers in assessing local tissue remodeling.http://www.sciencedirect.com/science/article/pii/S2665913124000943BiomarkersECMRevision surgeryCollagenJoint replacementOsteoarthritis |
| spellingShingle | Christian S. Thudium Sten Rasmussen Morten A. Karsdal Anne-Christine Bay-Jensen Association between type III collagen degradation and local tissue damage of a single joint Osteoarthritis and Cartilage Open Biomarkers ECM Revision surgery Collagen Joint replacement Osteoarthritis |
| title | Association between type III collagen degradation and local tissue damage of a single joint |
| title_full | Association between type III collagen degradation and local tissue damage of a single joint |
| title_fullStr | Association between type III collagen degradation and local tissue damage of a single joint |
| title_full_unstemmed | Association between type III collagen degradation and local tissue damage of a single joint |
| title_short | Association between type III collagen degradation and local tissue damage of a single joint |
| title_sort | association between type iii collagen degradation and local tissue damage of a single joint |
| topic | Biomarkers ECM Revision surgery Collagen Joint replacement Osteoarthritis |
| url | http://www.sciencedirect.com/science/article/pii/S2665913124000943 |
| work_keys_str_mv | AT christiansthudium associationbetweentypeiiicollagendegradationandlocaltissuedamageofasinglejoint AT stenrasmussen associationbetweentypeiiicollagendegradationandlocaltissuedamageofasinglejoint AT mortenakarsdal associationbetweentypeiiicollagendegradationandlocaltissuedamageofasinglejoint AT annechristinebayjensen associationbetweentypeiiicollagendegradationandlocaltissuedamageofasinglejoint |