Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae
Rhinoscleroma is a chronic, slowly progressive granulomatous bacterial infection that is endemic to the tropical world, namely, Central America and Africa. It is occasionally seen in the United States of America (USA). It predominately affects the nasal mucosa but can also involve the rest of the up...
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Case Reports in Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/2016/6536275 |
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| author | J. Gonzales Zamora A. R. Murali |
| author_facet | J. Gonzales Zamora A. R. Murali |
| author_sort | J. Gonzales Zamora |
| collection | DOAJ |
| description | Rhinoscleroma is a chronic, slowly progressive granulomatous bacterial infection that is endemic to the tropical world, namely, Central America and Africa. It is occasionally seen in the United States of America (USA). It predominately affects the nasal mucosa but can also involve the rest of the upper respiratory tract. The well-known causative agent for rhinoscleroma is the bacterium Klebsiella rhinoscleromatis, a subspecies of Klebsiella pneumoniae. However, Klebsiella ozaenae can also, albeit very rarely, cause rhinoscleroma. The diagnosis is confirmed by histopathology examination that shows the characteristic Mikulicz cells, considered pathognomonic for this infection. We report a patient with histologically proven rhinoscleroma with pharyngolaryngeal involvement in whom cultures yielded Klebsiella ozaenae. To the best of our knowledge, only two cases of rhinoscleroma due to Klebsiella ozaenae have been reported in the literature to date. Our case illustrates the importance of recognizing this infection in a nonendemic setting such as the USA. A lack of awareness and a delay in the diagnosis of this disease can lead to complications including upper airway obstruction, physical deformity, and, rarely, sepsis. In addition, it must be remembered that the treatment of rhinoscleroma is challenging and requires a prolonged course of antibiotics to achieve a definite cure and avoid relapses. |
| format | Article |
| id | doaj-art-ea1eecb8ecde4a9aaf948d03b1d9099f |
| institution | Kabale University |
| issn | 2090-6625 2090-6633 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Infectious Diseases |
| spelling | doaj-art-ea1eecb8ecde4a9aaf948d03b1d9099f2025-02-03T01:27:16ZengWileyCase Reports in Infectious Diseases2090-66252090-66332016-01-01201610.1155/2016/65362756536275Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenaeJ. Gonzales Zamora0A. R. Murali1Division of Infectious Diseases, Augusta University, Augusta, GA 30912, USADepartment of Gastroenterology, University of Iowa Hospital and Clinics, Iowa City, IA 52242, USARhinoscleroma is a chronic, slowly progressive granulomatous bacterial infection that is endemic to the tropical world, namely, Central America and Africa. It is occasionally seen in the United States of America (USA). It predominately affects the nasal mucosa but can also involve the rest of the upper respiratory tract. The well-known causative agent for rhinoscleroma is the bacterium Klebsiella rhinoscleromatis, a subspecies of Klebsiella pneumoniae. However, Klebsiella ozaenae can also, albeit very rarely, cause rhinoscleroma. The diagnosis is confirmed by histopathology examination that shows the characteristic Mikulicz cells, considered pathognomonic for this infection. We report a patient with histologically proven rhinoscleroma with pharyngolaryngeal involvement in whom cultures yielded Klebsiella ozaenae. To the best of our knowledge, only two cases of rhinoscleroma due to Klebsiella ozaenae have been reported in the literature to date. Our case illustrates the importance of recognizing this infection in a nonendemic setting such as the USA. A lack of awareness and a delay in the diagnosis of this disease can lead to complications including upper airway obstruction, physical deformity, and, rarely, sepsis. In addition, it must be remembered that the treatment of rhinoscleroma is challenging and requires a prolonged course of antibiotics to achieve a definite cure and avoid relapses.http://dx.doi.org/10.1155/2016/6536275 |
| spellingShingle | J. Gonzales Zamora A. R. Murali Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae Case Reports in Infectious Diseases |
| title | Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae |
| title_full | Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae |
| title_fullStr | Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae |
| title_full_unstemmed | Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae |
| title_short | Rhinoscleroma with Pharyngolaryngeal Involvement Caused by Klebsiella ozaenae |
| title_sort | rhinoscleroma with pharyngolaryngeal involvement caused by klebsiella ozaenae |
| url | http://dx.doi.org/10.1155/2016/6536275 |
| work_keys_str_mv | AT jgonzaleszamora rhinoscleromawithpharyngolaryngealinvolvementcausedbyklebsiellaozaenae AT armurali rhinoscleromawithpharyngolaryngealinvolvementcausedbyklebsiellaozaenae |