Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study
Objective:. This study examined whether there is an association between opioid-related mortality and surgical procedures. Methods:. A case-control study design using deceased controls compared individuals with and without opioid death and their exposure to common surgeries in the preceding 4 years....
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health
2024-06-01
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| Series: | Annals of Surgery Open |
| Online Access: | http://journals.lww.com/10.1097/AS9.0000000000000412 |
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| author | Mhd Wasem Alsabbagh, BScPhm, PhD Michael A. Beazely, BSP, PhD Leona Spasik, PharmD |
| author_facet | Mhd Wasem Alsabbagh, BScPhm, PhD Michael A. Beazely, BSP, PhD Leona Spasik, PharmD |
| author_sort | Mhd Wasem Alsabbagh, BScPhm, PhD |
| collection | DOAJ |
| description | Objective:. This study examined whether there is an association between opioid-related mortality and surgical procedures.
Methods:. A case-control study design using deceased controls compared individuals with and without opioid death and their exposure to common surgeries in the preceding 4 years. This population-based study used linked death and hospitalization databases in Canada (excluding Quebec) from January 01, 2008 to December 31, 2017. Cases of opioid death were identified and matched to 5 controls who died of other causes by age (±4 years), sex, province of death, and date of death (±1 year). Patients with HIV infection and alcohol-related deaths were excluded from the control group. Logistic regression was used to determine if there was an association between having surgery and death from an opioid-related cause by estimating the crude and adjusted odds ratios (ORs) with the corresponding 95% confidence interval (CI). Covariates included sociodemographic characteristics, comorbidities, and the number of days of hospitalization in the previous 4 years.
Results:. We identified 11,865 cases and matched them with 59,345 controls. About 11.2% of cases and 12.5% of controls had surgery in the 4 years before their death, corresponding to a crude OR of 0.89 (95% CI: 0.83–0.94). After adjustment, opioid mortality was associated with surgical procedure with OR of 1.26 (95% CI: 1.17–1.36).
Conclusions:. After adjusting for comorbidities, patients with opioid mortality were more likely to undergo surgical intervention within 4 years before their death. Clinicians should enhance screening for opioid use and risk factors when considering postoperative opioid prescribing. |
| format | Article |
| id | doaj-art-ea150e1cef244242808903e7ac6a1b60 |
| institution | Kabale University |
| issn | 2691-3593 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Wolters Kluwer Health |
| record_format | Article |
| series | Annals of Surgery Open |
| spelling | doaj-art-ea150e1cef244242808903e7ac6a1b602025-01-24T09:18:39ZengWolters Kluwer HealthAnnals of Surgery Open2691-35932024-06-0152e41210.1097/AS9.0000000000000412202406000-00012Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control StudyMhd Wasem Alsabbagh, BScPhm, PhD0Michael A. Beazely, BSP, PhD1Leona Spasik, PharmD2* From the School of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.* From the School of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.* From the School of Pharmacy, Faculty of Science, University of Waterloo, Waterloo, ON, Canada.Objective:. This study examined whether there is an association between opioid-related mortality and surgical procedures. Methods:. A case-control study design using deceased controls compared individuals with and without opioid death and their exposure to common surgeries in the preceding 4 years. This population-based study used linked death and hospitalization databases in Canada (excluding Quebec) from January 01, 2008 to December 31, 2017. Cases of opioid death were identified and matched to 5 controls who died of other causes by age (±4 years), sex, province of death, and date of death (±1 year). Patients with HIV infection and alcohol-related deaths were excluded from the control group. Logistic regression was used to determine if there was an association between having surgery and death from an opioid-related cause by estimating the crude and adjusted odds ratios (ORs) with the corresponding 95% confidence interval (CI). Covariates included sociodemographic characteristics, comorbidities, and the number of days of hospitalization in the previous 4 years. Results:. We identified 11,865 cases and matched them with 59,345 controls. About 11.2% of cases and 12.5% of controls had surgery in the 4 years before their death, corresponding to a crude OR of 0.89 (95% CI: 0.83–0.94). After adjustment, opioid mortality was associated with surgical procedure with OR of 1.26 (95% CI: 1.17–1.36). Conclusions:. After adjusting for comorbidities, patients with opioid mortality were more likely to undergo surgical intervention within 4 years before their death. Clinicians should enhance screening for opioid use and risk factors when considering postoperative opioid prescribing.http://journals.lww.com/10.1097/AS9.0000000000000412 |
| spellingShingle | Mhd Wasem Alsabbagh, BScPhm, PhD Michael A. Beazely, BSP, PhD Leona Spasik, PharmD Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study Annals of Surgery Open |
| title | Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study |
| title_full | Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study |
| title_fullStr | Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study |
| title_full_unstemmed | Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study |
| title_short | Association Between Opioid-Related Mortality and History of Surgical Procedure: A Population-Based Case-Control Study |
| title_sort | association between opioid related mortality and history of surgical procedure a population based case control study |
| url | http://journals.lww.com/10.1097/AS9.0000000000000412 |
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