Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia
ABSTRACT Background Cachexia is a poor prognostic factor in many advanced cancers. Cachexia diagnostic criteria of the European Palliative Care Research Collaboration (EPCRC) may underestimate cachexia in Asians; therefore, new criteria have been proposed by the Asian Working Group for Cachexia (AWG...
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| Format: | Article |
| Language: | English |
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Wiley
2025-01-01
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| Series: | Thoracic Cancer |
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| Online Access: | https://doi.org/10.1111/1759-7714.15503 |
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| author | Utae Katsushima Takuya Fukushima Jiro Nakano Naoya Ogushi Kazuki Fujii Yutaro Nagata Keisuke Kamisako Yukiko Okuno Yuta Okazaki Kentaro Nakanishi Kiyori Yoshida Tatsuki Ikoma Yuki Takeyasu Yuta Yamanaka Hiroshige Yoshioka Kimitaka Hase Takayasu Kurata |
| author_facet | Utae Katsushima Takuya Fukushima Jiro Nakano Naoya Ogushi Kazuki Fujii Yutaro Nagata Keisuke Kamisako Yukiko Okuno Yuta Okazaki Kentaro Nakanishi Kiyori Yoshida Tatsuki Ikoma Yuki Takeyasu Yuta Yamanaka Hiroshige Yoshioka Kimitaka Hase Takayasu Kurata |
| author_sort | Utae Katsushima |
| collection | DOAJ |
| description | ABSTRACT Background Cachexia is a poor prognostic factor in many advanced cancers. Cachexia diagnostic criteria of the European Palliative Care Research Collaboration (EPCRC) may underestimate cachexia in Asians; therefore, new criteria have been proposed by the Asian Working Group for Cachexia (AWGC). We compared both criteria to determine differences in diagnostic rates and their association with lung cancer prognosis. Patients and Methods This single‐center, retrospective cohort study considered lung cancer outpatients receiving chemotherapy. Survival was analyzed using Kaplan–Meier curves and log‐rank tests. The association between cachexia diagnosis and prognosis was examined for each set of criteria using a Cox proportional hazards model. C‐statistic analysis was performed to compare the discriminative power for prognosis. Results Among the 106 participants analyzed (median age, 75 [71–79] years; 75 males [70.8%]; 91 [85.9%] with performance status [PS] 0–1), 58 (54.7%) and 77 (72.6%) cachexia cases were diagnosed using the EPCRC and AWGC criteria, respectively. The latter encompassed all but one patient diagnosed using the EPCRC criteria. Patients with cachexia had a significantly poorer prognosis according to both criteria (EPCRC, p = 0.002; AWGC, p = 0.001). Both criteria had almost equal discriminative power for prognosis (EPCRC, C‐statistic = 0.658; AWGC, C‐statistic = 0.658). CRP in the AWGC criteria was most strongly related to prognosis. Conclusions Cachexia was an independent poor prognostic factor in lung cancer patients receiving chemotherapy under the AWGC and EPCRC criteria, both of which had similar prognostic discriminatory power. Among CRP, anorexia, and grip strength, elevated CRP may be the most prognostically relevant parameter in the AWGC criteria. |
| format | Article |
| id | doaj-art-ea121353bfcb4b2c8c213f48946ac9b0 |
| institution | Kabale University |
| issn | 1759-7706 1759-7714 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Thoracic Cancer |
| spelling | doaj-art-ea121353bfcb4b2c8c213f48946ac9b02025-01-30T22:40:34ZengWileyThoracic Cancer1759-77061759-77142025-01-01162n/an/a10.1111/1759-7714.15503Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for CachexiaUtae Katsushima0Takuya Fukushima1Jiro Nakano2Naoya Ogushi3Kazuki Fujii4Yutaro Nagata5Keisuke Kamisako6Yukiko Okuno7Yuta Okazaki8Kentaro Nakanishi9Kiyori Yoshida10Tatsuki Ikoma11Yuki Takeyasu12Yuta Yamanaka13Hiroshige Yoshioka14Kimitaka Hase15Takayasu Kurata16Department of Thoracic Oncology Kansai Medical University Osaka JapanFaculty of Rehabilitation Kansai Medical University Osaka JapanFaculty of Rehabilitation Kansai Medical University Osaka JapanDepartment of Physical Medicine and Rehabilitation Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanDepartment of Physical Medicine and Rehabilitation Kansai Medical University Osaka JapanDepartment of Thoracic Oncology Kansai Medical University Osaka JapanABSTRACT Background Cachexia is a poor prognostic factor in many advanced cancers. Cachexia diagnostic criteria of the European Palliative Care Research Collaboration (EPCRC) may underestimate cachexia in Asians; therefore, new criteria have been proposed by the Asian Working Group for Cachexia (AWGC). We compared both criteria to determine differences in diagnostic rates and their association with lung cancer prognosis. Patients and Methods This single‐center, retrospective cohort study considered lung cancer outpatients receiving chemotherapy. Survival was analyzed using Kaplan–Meier curves and log‐rank tests. The association between cachexia diagnosis and prognosis was examined for each set of criteria using a Cox proportional hazards model. C‐statistic analysis was performed to compare the discriminative power for prognosis. Results Among the 106 participants analyzed (median age, 75 [71–79] years; 75 males [70.8%]; 91 [85.9%] with performance status [PS] 0–1), 58 (54.7%) and 77 (72.6%) cachexia cases were diagnosed using the EPCRC and AWGC criteria, respectively. The latter encompassed all but one patient diagnosed using the EPCRC criteria. Patients with cachexia had a significantly poorer prognosis according to both criteria (EPCRC, p = 0.002; AWGC, p = 0.001). Both criteria had almost equal discriminative power for prognosis (EPCRC, C‐statistic = 0.658; AWGC, C‐statistic = 0.658). CRP in the AWGC criteria was most strongly related to prognosis. Conclusions Cachexia was an independent poor prognostic factor in lung cancer patients receiving chemotherapy under the AWGC and EPCRC criteria, both of which had similar prognostic discriminatory power. Among CRP, anorexia, and grip strength, elevated CRP may be the most prognostically relevant parameter in the AWGC criteria.https://doi.org/10.1111/1759-7714.15503cancer cachexialung cancernew cachexia diagnostic criteria for Asiansprognosis |
| spellingShingle | Utae Katsushima Takuya Fukushima Jiro Nakano Naoya Ogushi Kazuki Fujii Yutaro Nagata Keisuke Kamisako Yukiko Okuno Yuta Okazaki Kentaro Nakanishi Kiyori Yoshida Tatsuki Ikoma Yuki Takeyasu Yuta Yamanaka Hiroshige Yoshioka Kimitaka Hase Takayasu Kurata Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia Thoracic Cancer cancer cachexia lung cancer new cachexia diagnostic criteria for Asians prognosis |
| title | Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia |
| title_full | Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia |
| title_fullStr | Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia |
| title_full_unstemmed | Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia |
| title_short | Comparative Study on Associations Between Lung Cancer Prognosis and Diagnostic Criteria Set by the European Palliative Care Research Collaboration and the Asian Working Group for Cachexia |
| title_sort | comparative study on associations between lung cancer prognosis and diagnostic criteria set by the european palliative care research collaboration and the asian working group for cachexia |
| topic | cancer cachexia lung cancer new cachexia diagnostic criteria for Asians prognosis |
| url | https://doi.org/10.1111/1759-7714.15503 |
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