Empagliflozin targeted the immune-related gene PIK3CA in type 2 diabetes mellitus treatment: network pharmacology analysis and experimental evidence

Empagliflozin targeted the immune-related gene PIK3CA in type 2 diabetes mellitus treatment: network pharmacology analysis and experimental evidence

Abstract Background Type 2 diabetes mellitus (T2DM) is linked to elevated blood glucose due to insulin resistance. Empagliflozin has demonstrated efficacy in T2DM management, with potential immune-modulatory effects. This study aimed to investigate the immune-related mechanisms of empagliflozin in T...

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Bibliographic Details
Main Authors: Heng Zhong, Guo-Juan Sun, Fu-Man Du, Wei-Min Wang, Bin-Hong Duan, Hong Qiao
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Diabetology & Metabolic Syndrome
Subjects:
Type 2 diabetes mellitus
Empagliflozin
Immune-related genes
PIK3CA
Immunomodulation
Macrophage
Online Access:https://doi.org/10.1186/s13098-025-01895-2
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https://doi.org/10.1186/s13098-025-01895-2

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