Allo-Priming Reverses Immunosenescence and May Restore Broad Respiratory Viral Protection and Vaccine Responsiveness to the Elderly: Results of a Phase I/II Clinical Trial

Allo-Priming Reverses Immunosenescence and May Restore Broad Respiratory Viral Protection and Vaccine Responsiveness to the Elderly: Results of a Phase I/II Clinical Trial

Respiratory viral infections pose a significant health problem that disproportionately affects the elderly. With the aging worldwide population being less responsive to protective vaccines, there is an urgent need for strategies that can protect the elderly from community-acquired viral infections....

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Bibliographic Details
Main Authors: Canhui Liu, Xiaochuan Yang, Jorge Paoli-Bruno, David Sikes, Alejandra V. Marin-Ruiz, Nicole Thomas, Ryan Shane, Michael Har-Noy
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Vaccines
Subjects:
Th1/Th2 balance
immunosenescence
heterologous immunity
cellular immunity
respiratory viral infection
interferon gamma
Online Access:https://www.mdpi.com/2076-393X/13/5/463
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