Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma
To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-04-01
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| Series: | Tumor Biology |
| Online Access: | https://doi.org/10.1177/1010428317695527 |
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| author | Maisa Ribeiro Sarah R Teixeira Monarko N Azevedo Ailton C Fraga Jr Antônio PM Gontijo Eneida F Vêncio |
| author_facet | Maisa Ribeiro Sarah R Teixeira Monarko N Azevedo Ailton C Fraga Jr Antônio PM Gontijo Eneida F Vêncio |
| author_sort | Maisa Ribeiro |
| collection | DOAJ |
| description | To investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data were reviewed from medical records. Hypoxia-induced factor-1 alpha status was distinct according to tumor location, subtype and topography affect. In superficial oral squamous cell carcinomas, most tumor cells overexpressed hypoxia-induced factor-1 alpha, whereas hypoxia-induced factor-1 alpha was restricted to the intratumoral region in conventional squamous cell carcinomas. All basaloid squamous cell carcinomas exhibited downregulation of hypoxia-induced factor-1 alpha. Interestingly, metastatic lymph nodes (91.7%, p = 0.001) and the intratumoral regions of corresponding primary tumors (58.3%, p = 0.142) showed hypoxia-induced factor-1 alpha-positive tumor cells. Overall survival was poor in patients with metastatic lymph nodes. Hypoxia-induced factor-1 alpha has distinct expression patterns in different oral squamous cell carcinoma subtypes and topographies, suggesting that low oxygen tension promotes the growth pattern of superficial and conventional squamous cell carcinoma, but not basaloid squamous cell carcinoma. Indeed, a hypoxic environment may facilitate regional metastasis, making it a useful diagnostic and prognostic marker in primary tumors. |
| format | Article |
| id | doaj-art-e9f4e9477d5b4d22a867ea9367cab47c |
| institution | Kabale University |
| issn | 1423-0380 |
| language | English |
| publishDate | 2017-04-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Tumor Biology |
| spelling | doaj-art-e9f4e9477d5b4d22a867ea9367cab47c2025-08-20T03:39:18ZengSAGE PublishingTumor Biology1423-03802017-04-013910.1177/1010428317695527Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinomaMaisa Ribeiro0Sarah R Teixeira1Monarko N Azevedo2Ailton C Fraga Jr3Antônio PM Gontijo4Eneida F Vêncio5School of Dentistry, Federal University of Goiás, Goiânia, BrazilSchool of Dentistry, Federal University of Goiás, Goiânia, BrazilSchool of Dentistry, Federal University of Goiás, Goiânia, BrazilAnatomic Pathology Sector, Araújo Jorge Hospital, Goiânia, BrazilHead and Neck Sector, Araújo Jorge Hospital, Goiânia, BrazilSchool of Dentistry, Federal University of Goiás, Goiânia, BrazilTo investigate hypoxia-induced factor-1 alpha expression in distinct oral squamous cell carcinoma subtypes and topographies and correlate with clinicopathological data. Hypoxia-induced factor-1 alpha expression was assessed by immunohistochemistry in 93 cases of OSCC. Clinical and histopathological data were reviewed from medical records. Hypoxia-induced factor-1 alpha status was distinct according to tumor location, subtype and topography affect. In superficial oral squamous cell carcinomas, most tumor cells overexpressed hypoxia-induced factor-1 alpha, whereas hypoxia-induced factor-1 alpha was restricted to the intratumoral region in conventional squamous cell carcinomas. All basaloid squamous cell carcinomas exhibited downregulation of hypoxia-induced factor-1 alpha. Interestingly, metastatic lymph nodes (91.7%, p = 0.001) and the intratumoral regions of corresponding primary tumors (58.3%, p = 0.142) showed hypoxia-induced factor-1 alpha-positive tumor cells. Overall survival was poor in patients with metastatic lymph nodes. Hypoxia-induced factor-1 alpha has distinct expression patterns in different oral squamous cell carcinoma subtypes and topographies, suggesting that low oxygen tension promotes the growth pattern of superficial and conventional squamous cell carcinoma, but not basaloid squamous cell carcinoma. Indeed, a hypoxic environment may facilitate regional metastasis, making it a useful diagnostic and prognostic marker in primary tumors.https://doi.org/10.1177/1010428317695527 |
| spellingShingle | Maisa Ribeiro Sarah R Teixeira Monarko N Azevedo Ailton C Fraga Jr Antônio PM Gontijo Eneida F Vêncio Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma Tumor Biology |
| title | Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma |
| title_full | Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma |
| title_fullStr | Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma |
| title_full_unstemmed | Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma |
| title_short | Expression of hypoxia-induced factor-1 alpha in early-stage and in metastatic oral squamous cell carcinoma |
| title_sort | expression of hypoxia induced factor 1 alpha in early stage and in metastatic oral squamous cell carcinoma |
| url | https://doi.org/10.1177/1010428317695527 |
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