Lipid raft disruption inhibits the activation of Transient Receptor Potential Vanilloid 1, but not TRP Melastatin 3 and the voltage-gated L-type calcium channels in sensory neurons

Lipid raft disruption inhibits the activation of Transient Receptor Potential Vanilloid 1, but not TRP Melastatin 3 and the voltage-gated L-type calcium channels in sensory neurons

Transient Receptor Potential (TRP) ion channels like Vanilloid 1 (TRPV1) and Melastatin 3 (TRPM3) are nonselective cation channels expressed in primary sensory neurons and peripheral nerve endings, which are located in cholesterol- and sphingolipid-rich membrane lipid raft regions and have important...

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Bibliographic Details
Main Authors: Maja Payrits, Balázs Zoltán Zsidó, Andrea Kinga Nehr-Majoros, Rita Börzsei, Zsuzsanna Helyes, Csaba Hetényi, Éva Szőke
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
TRPV1
TRPM3
L-type voltage-gated Ca2+ channel
CIM0216
FPL 64176
veratridine
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2024.1452306/full
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