Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula
Objective To observe the effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula(AVF).Methods Weretrospectively analyzed 312 uraemia patients who received AVF operation first time between January 2013 and March...
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Editorial Department of Journal of Clinical Nephrology
2015-01-01
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| Series: | Linchuang shenzangbing zazhi |
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| Online Access: | http://www.lcszb.com/thesisDetails?columnId=57920538&Fpath=home&index=0 |
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| author | YU Chong YAN Jian-jun YU Yang HE Fan Xiong Wen-fang LIU Wei |
| author_facet | YU Chong YAN Jian-jun YU Yang HE Fan Xiong Wen-fang LIU Wei |
| author_sort | YU Chong |
| collection | DOAJ |
| description | Objective To observe the effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula(AVF).Methods Weretrospectively analyzed 312 uraemia patients who received AVF operation first time between January 2013 and March 2014.All patients were given radialartery-cephalic vein standard fistulation.Forty-six patients were administered alprostadil(20 μg i.v.drip for 3 days in hospital) combined with beraprost sodium tablet(20 μg P.O.for 3 months for outpatient) sequential therapy as study group.Forty-six patients without treatment of alprostadil or beraprost sodium were included into control group.These two groups had the same clinical materials,such as age,the diameter of artery and vein before operation,primary disease constitution rate.The fistula dysfunctional rate in 1 year,fistula mutation time,average fistula flow volume and arterial end diastolic velocity 1 year postoperation were assessed.Results In study and control groups,the fistula dysfunctional rate was 10.9%and28.2%respectively(P=0.035 5),the mean maturation time was(42.1±6.5)and(55.5±5.8) days respectively(P<0.001),the mean blood flow was(789 ± 101) and(556 ± 132) mL/min respectively(P<0.001),and the arterial end diastolic velocity was(151.5 ± 14.5) and(113 ± 20.1) cm/s respectively(P<0.001).Conclusions Our data indicated that the sequential therapy of alprostadil combined with beraprost sodium tablet is effective and safe for the prevention of primary AVF failure in hemodialysis patients and early fistula dysfunction. |
| format | Article |
| id | doaj-art-e9e9fa11fbe54e39bf2c4e9449ff2769 |
| institution | Kabale University |
| issn | 1671-2390 |
| language | zho |
| publishDate | 2015-01-01 |
| publisher | Editorial Department of Journal of Clinical Nephrology |
| record_format | Article |
| series | Linchuang shenzangbing zazhi |
| spelling | doaj-art-e9e9fa11fbe54e39bf2c4e9449ff27692025-08-20T03:49:02ZzhoEditorial Department of Journal of Clinical NephrologyLinchuang shenzangbing zazhi1671-23902015-01-0165565857920538Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistulaYU ChongYAN Jian-junYU YangHE FanXiong Wen-fangLIU WeiObjective To observe the effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula(AVF).Methods Weretrospectively analyzed 312 uraemia patients who received AVF operation first time between January 2013 and March 2014.All patients were given radialartery-cephalic vein standard fistulation.Forty-six patients were administered alprostadil(20 μg i.v.drip for 3 days in hospital) combined with beraprost sodium tablet(20 μg P.O.for 3 months for outpatient) sequential therapy as study group.Forty-six patients without treatment of alprostadil or beraprost sodium were included into control group.These two groups had the same clinical materials,such as age,the diameter of artery and vein before operation,primary disease constitution rate.The fistula dysfunctional rate in 1 year,fistula mutation time,average fistula flow volume and arterial end diastolic velocity 1 year postoperation were assessed.Results In study and control groups,the fistula dysfunctional rate was 10.9%and28.2%respectively(P=0.035 5),the mean maturation time was(42.1±6.5)and(55.5±5.8) days respectively(P<0.001),the mean blood flow was(789 ± 101) and(556 ± 132) mL/min respectively(P<0.001),and the arterial end diastolic velocity was(151.5 ± 14.5) and(113 ± 20.1) cm/s respectively(P<0.001).Conclusions Our data indicated that the sequential therapy of alprostadil combined with beraprost sodium tablet is effective and safe for the prevention of primary AVF failure in hemodialysis patients and early fistula dysfunction.http://www.lcszb.com/thesisDetails?columnId=57920538&Fpath=home&index=0Arteriovenous fistulaAlprostadilBeraprostArteriovenous fistula maturation |
| spellingShingle | YU Chong YAN Jian-jun YU Yang HE Fan Xiong Wen-fang LIU Wei Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula Linchuang shenzangbing zazhi Arteriovenous fistula Alprostadil Beraprost Arteriovenous fistula maturation |
| title | Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula |
| title_full | Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula |
| title_fullStr | Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula |
| title_full_unstemmed | Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula |
| title_short | Effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula |
| title_sort | effect of alprostadil combined with beraprost sodium tablet sequential therapy in early mutation and long term survival of arteriovenous fistula |
| topic | Arteriovenous fistula Alprostadil Beraprost Arteriovenous fistula maturation |
| url | http://www.lcszb.com/thesisDetails?columnId=57920538&Fpath=home&index=0 |
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