Effects of combined metformin and semaglutide therapy on body weight, metabolic parameters, and reproductive outcomes in overweight/obese women with polycystic ovary syndrome: a prospective, randomized, controlled, open-label clinical trial

Effects of combined metformin and semaglutide therapy on body weight, metabolic parameters, and reproductive outcomes in overweight/obese women with polycystic ovary syndrome: a prospective, randomized, controlled, open-label clinical trial

Abstract Objective This study aimed to assess the effects of metformin (MET) monotherapy versus a combination of semaglutide and MET on weight, metabolism, reproductive function, and inflammatory markers in women with polycystic ovary syndrome (PCOS). Methods A total of 100 overweight or obese women...

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Bibliographic Details
Main Authors: Haiyan Chen, Xiaohui Lei, Zhuoran Yang, Yuxin Xu, Dongfang Liu, Cong Wang, Hu Du
Format: Article
Language:English
Published: BMC 2025-07-01
Series:Reproductive Biology and Endocrinology
Subjects:
Semaglutide
Polycystic ovary syndrome
Metformin
Pregnancy outcomes
Online Access:https://doi.org/10.1186/s12958-025-01447-3
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