Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy
<b>Background:</b> This study aims to evaluate the quantitative changes in retinal nerve fiber layer (RNFL) thickness and radial peripapillary capillary (RPC) vessel density in patients with chronic central serous chorioretinopathy (CSCR), specifically excluding the peripapillary region....
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MDPI AG
2025-01-01
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| author | Esra Kızıldağ Özbay Şenol Sabancı Mehmet Fatih Küçük Muhammet Kazım Erol |
| author_facet | Esra Kızıldağ Özbay Şenol Sabancı Mehmet Fatih Küçük Muhammet Kazım Erol |
| author_sort | Esra Kızıldağ Özbay |
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| description | <b>Background:</b> This study aims to evaluate the quantitative changes in retinal nerve fiber layer (RNFL) thickness and radial peripapillary capillary (RPC) vessel density in patients with chronic central serous chorioretinopathy (CSCR), specifically excluding the peripapillary region. <b>Methods:</b> A prospective case–control study was conducted at the Antalya Training and Research Hospital, Health Sciences University, involving 65 patients with chronic CSCR. Participants were categorized into two groups based on the presence or regression of subretinal fluid (SRF). A control group of age- and sex-matched healthy individuals was also included. Optical coherence tomography angiography (OCTA) was used to assess RNFL thickness and RPC vessel density. Statistical analyses were conducted using SPSS, with non-parametric tests employed for between-group comparisons. <b>Results:</b> Patients with persistent SRF exhibited significant increases in RNFL thickness in the inferior and nasal quadrants compared to healthy controls (<i>p</i> = 0.003 and <i>p</i> = 0.014, respectively). Additionally, RPC vessel density in the small vessel disc area (%) was significantly lower in the persistent SRF group compared to controls (<i>p</i> = 0.021). A significant negative correlation was found between nasal quadrant RNFL thickness and small vessel disc area (<i>p</i> = 0.014, r = −0.306). <b>Conclusions:</b> Chronic SRF in CSCR patients, even when not involving the peripapillary region, leads to significant structural changes in both the neural and vascular components of the retina. These findings suggest that SRF contributes to broader retinal alterations and supports the need for early detection and management of CSCR to prevent long-term visual impairment. |
| format | Article |
| id | doaj-art-e9dfb3bd803b482c9e8e10871e358a1c |
| institution | Kabale University |
| issn | 2075-4418 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
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| series | Diagnostics |
| spelling | doaj-art-e9dfb3bd803b482c9e8e10871e358a1c2025-01-24T13:29:00ZengMDPI AGDiagnostics2075-44182025-01-0115217410.3390/diagnostics15020174Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous ChorioretinopathyEsra Kızıldağ Özbay0Şenol Sabancı1Mehmet Fatih Küçük2Muhammet Kazım Erol3Department of Ophthalmology Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., 07100 Antalya, TurkeyDepartment of Ophthalmology Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., 07100 Antalya, TurkeyDepartment of Ophthalmology Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., 07100 Antalya, TurkeyDepartment of Ophthalmology Antalya Training and Research Hospital, Varlık, Kazım Karabekir Cd., 07100 Antalya, Turkey<b>Background:</b> This study aims to evaluate the quantitative changes in retinal nerve fiber layer (RNFL) thickness and radial peripapillary capillary (RPC) vessel density in patients with chronic central serous chorioretinopathy (CSCR), specifically excluding the peripapillary region. <b>Methods:</b> A prospective case–control study was conducted at the Antalya Training and Research Hospital, Health Sciences University, involving 65 patients with chronic CSCR. Participants were categorized into two groups based on the presence or regression of subretinal fluid (SRF). A control group of age- and sex-matched healthy individuals was also included. Optical coherence tomography angiography (OCTA) was used to assess RNFL thickness and RPC vessel density. Statistical analyses were conducted using SPSS, with non-parametric tests employed for between-group comparisons. <b>Results:</b> Patients with persistent SRF exhibited significant increases in RNFL thickness in the inferior and nasal quadrants compared to healthy controls (<i>p</i> = 0.003 and <i>p</i> = 0.014, respectively). Additionally, RPC vessel density in the small vessel disc area (%) was significantly lower in the persistent SRF group compared to controls (<i>p</i> = 0.021). A significant negative correlation was found between nasal quadrant RNFL thickness and small vessel disc area (<i>p</i> = 0.014, r = −0.306). <b>Conclusions:</b> Chronic SRF in CSCR patients, even when not involving the peripapillary region, leads to significant structural changes in both the neural and vascular components of the retina. These findings suggest that SRF contributes to broader retinal alterations and supports the need for early detection and management of CSCR to prevent long-term visual impairment.https://www.mdpi.com/2075-4418/15/2/174central serous chorioretinopathy (CSCR)retinal nerve fiber layer (RNFL) thicknessradial peripapillary capillary (RPC) vessel densitysubretinal fluid (SRF)optical coherence tomography angiography (OCTA) |
| spellingShingle | Esra Kızıldağ Özbay Şenol Sabancı Mehmet Fatih Küçük Muhammet Kazım Erol Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy Diagnostics central serous chorioretinopathy (CSCR) retinal nerve fiber layer (RNFL) thickness radial peripapillary capillary (RPC) vessel density subretinal fluid (SRF) optical coherence tomography angiography (OCTA) |
| title | Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy |
| title_full | Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy |
| title_fullStr | Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy |
| title_full_unstemmed | Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy |
| title_short | Quantitative Changes in Vascular and Neural Fibers Induced by Subretinal Fluid Excluding the Peripapillary Region in Patients with Chronic Central Serous Chorioretinopathy |
| title_sort | quantitative changes in vascular and neural fibers induced by subretinal fluid excluding the peripapillary region in patients with chronic central serous chorioretinopathy |
| topic | central serous chorioretinopathy (CSCR) retinal nerve fiber layer (RNFL) thickness radial peripapillary capillary (RPC) vessel density subretinal fluid (SRF) optical coherence tomography angiography (OCTA) |
| url | https://www.mdpi.com/2075-4418/15/2/174 |
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