Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axis
Oral ulcers, a prevalent mucosal disorder with high recurrence rates, remain challenging to treat due to the oral cavity's dynamic environment and the multifactorial nature of ulcer progression. Here, we report a multifunctional microneedle (MN) patch loaded with astragalus polysaccharide (APS-...
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Elsevier
2025-06-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425004338 |
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| author | Qiang Zhang Tuo Wang Junyu Ren Yanru Guo Ziyi Yin Chenrui Zhang Honglin Fan Yinting Ren Junlong Da Narisu Hu |
| author_facet | Qiang Zhang Tuo Wang Junyu Ren Yanru Guo Ziyi Yin Chenrui Zhang Honglin Fan Yinting Ren Junlong Da Narisu Hu |
| author_sort | Qiang Zhang |
| collection | DOAJ |
| description | Oral ulcers, a prevalent mucosal disorder with high recurrence rates, remain challenging to treat due to the oral cavity's dynamic environment and the multifactorial nature of ulcer progression. Here, we report a multifunctional microneedle (MN) patch loaded with astragalus polysaccharide (APS-MN) that integrates rapid mucosal penetration, reactive oxygen species (ROS) scavenging, and ferroptosis inhibition to accelerate ulcer healing. Unlike conventional MN systems reliant on synthetic drugs or prolonged dissolution, APS-MN leverages the natural antioxidant and immunomodulatory properties of APS-a traditional Chinese medicine-derived polysaccharide-enabling complete drug release within 2 min and targeted delivery to ulcer bases. In vitro and in vivo studies demonstrate that APS-MN promotes M2 macrophage polarization, suppresses pro-inflammatory cytokines (TNF-α, IL-1β), and inhibits ferroptosis via the Nrf2/HO-1/SLC7A11 axis, achieving 88.2 % wound closure in rats within 6 days. Notably, this work combined herbal polysaccharides with MN technology for oral ulcer therapy, offering a biocompatible, non-invasive alternative to corticosteroids and antibiotics. The rapid dissolution, dual antioxidant/anti-ferroptotic action, and scalability of APS-MN position it as a transformative platform for managing recurrent oral ulcers and other redox-imbalanced mucosal diseases. |
| format | Article |
| id | doaj-art-e9dd8f3d3aac4ea69b74e5a7dde6c251 |
| institution | DOAJ |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-e9dd8f3d3aac4ea69b74e5a7dde6c2512025-08-20T03:12:57ZengElsevierMaterials Today Bio2590-00642025-06-013210187310.1016/j.mtbio.2025.101873Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axisQiang Zhang0Tuo Wang1Junyu Ren2Yanru Guo3Ziyi Yin4Chenrui Zhang5Honglin Fan6Yinting Ren7Junlong Da8Narisu Hu9Harbin Medical University, Harbin, 150001, Heilongjiang, ChinaDepartment of Stomatology, The People's Hospital of Laibin, Laibin, 546100, Guangxi, ChinaOral Implant Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China; Corresponding author.Oral Implant Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, ChinaHarbin Medical University, Harbin, 150001, Heilongjiang, ChinaOral Implant Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, ChinaOral Implant Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, ChinaDepartment of Stomatology, The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan, 528000, Guangdong, China; Department of Stomatology, Foshan Hospital of Traditional Chinese Medicine, Foshan, 528000, Guangdong, ChinaDepartment of Stomatology Center, The First People's Hospital of Foshan, Foshan, 528000, Guangdong, China; Corresponding author.Oral Implant Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang, China; Corresponding author.Oral ulcers, a prevalent mucosal disorder with high recurrence rates, remain challenging to treat due to the oral cavity's dynamic environment and the multifactorial nature of ulcer progression. Here, we report a multifunctional microneedle (MN) patch loaded with astragalus polysaccharide (APS-MN) that integrates rapid mucosal penetration, reactive oxygen species (ROS) scavenging, and ferroptosis inhibition to accelerate ulcer healing. Unlike conventional MN systems reliant on synthetic drugs or prolonged dissolution, APS-MN leverages the natural antioxidant and immunomodulatory properties of APS-a traditional Chinese medicine-derived polysaccharide-enabling complete drug release within 2 min and targeted delivery to ulcer bases. In vitro and in vivo studies demonstrate that APS-MN promotes M2 macrophage polarization, suppresses pro-inflammatory cytokines (TNF-α, IL-1β), and inhibits ferroptosis via the Nrf2/HO-1/SLC7A11 axis, achieving 88.2 % wound closure in rats within 6 days. Notably, this work combined herbal polysaccharides with MN technology for oral ulcer therapy, offering a biocompatible, non-invasive alternative to corticosteroids and antibiotics. The rapid dissolution, dual antioxidant/anti-ferroptotic action, and scalability of APS-MN position it as a transformative platform for managing recurrent oral ulcers and other redox-imbalanced mucosal diseases.http://www.sciencedirect.com/science/article/pii/S2590006425004338Oral ulcersAstragalus polysaccharideMicroneedleROSFerroptosis |
| spellingShingle | Qiang Zhang Tuo Wang Junyu Ren Yanru Guo Ziyi Yin Chenrui Zhang Honglin Fan Yinting Ren Junlong Da Narisu Hu Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axis Materials Today Bio Oral ulcers Astragalus polysaccharide Microneedle ROS Ferroptosis |
| title | Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axis |
| title_full | Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axis |
| title_fullStr | Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axis |
| title_full_unstemmed | Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axis |
| title_short | Multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via Nrf2/HO-1/SLC7A11 axis |
| title_sort | multifunctional astragalus polysaccharide composited microneedle promotes oral ulcers healing by inhibiting ferroptosis via nrf2 ho 1 slc7a11 axis |
| topic | Oral ulcers Astragalus polysaccharide Microneedle ROS Ferroptosis |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425004338 |
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