Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China
BackgroundWilms tumor (WT), which represents about 90% of kidney tumors in children, is the most prevalent type of renal tumor among children. In developed countries, advancements in treatments such as chemotherapy and radiotherapy have led to high survival rates. However, developing countries face...
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Pediatrics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fped.2025.1527039/full |
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| author | Kongkong Cui Kongkong Cui Peng Hong Peng Hong Jie Lin Jie Lin Zaihong Hu Zaihong Hu Zhiqiang Gao Zhiqiang Gao XiaoMao Tian XiaoMao Tian Tao Lin Tao Lin Qinlin Shi Qinlin Shi Guanghui Wei Guanghui Wei |
| author_facet | Kongkong Cui Kongkong Cui Peng Hong Peng Hong Jie Lin Jie Lin Zaihong Hu Zaihong Hu Zhiqiang Gao Zhiqiang Gao XiaoMao Tian XiaoMao Tian Tao Lin Tao Lin Qinlin Shi Qinlin Shi Guanghui Wei Guanghui Wei |
| author_sort | Kongkong Cui |
| collection | DOAJ |
| description | BackgroundWilms tumor (WT), which represents about 90% of kidney tumors in children, is the most prevalent type of renal tumor among children. In developed countries, advancements in treatments such as chemotherapy and radiotherapy have led to high survival rates. However, developing countries face significant challenges, including late-stage diagnosis, metastasis at presentation, and high rates of treatment abandonment.MethodsThis retrospective study included all patients diagnosed with WT at a tertiary hospital in Western China from 2007 to 2021. It involved the collection of sociodemographic and clinical details, including data on patients who abandoned treatment. Follow-up continued until July 2024.ResultsThis study consisted of 301 WT patients. Of the 259 who completed the treatment, the 5-year event-free survival (EFS) and overall survival (OS) rates were 77.9% and 81.2%. Of the 42 patients who abandoned treatment, 13 refused further care immediately after diagnosis and signed a refusal document, 16 discontinued treatments during preoperative neoadjuvant chemotherapy, and 13 failed to complete the prescribed chemotherapy or radiotherapy.ConclusionSurvival rates for WT patients at our institution approach those reported in developed countries. Challenges include late-stage diagnosis, metastasis at initial presentation, and treatment abandonment. To address these issues, implementing pediatric screening is critical for early detection and timely intervention, particularly for families vulnerable to abandoning treatment. For high-risk cases, oncologists need develop targeted strategies to enhance clinical outcomes. |
| format | Article |
| id | doaj-art-e9dcd0fbf4ca48cf93f1286bcf3a9a0e |
| institution | DOAJ |
| issn | 2296-2360 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pediatrics |
| spelling | doaj-art-e9dcd0fbf4ca48cf93f1286bcf3a9a0e2025-08-20T03:10:10ZengFrontiers Media S.A.Frontiers in Pediatrics2296-23602025-04-011310.3389/fped.2025.15270391527039Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in ChinaKongkong Cui0Kongkong Cui1Peng Hong2Peng Hong3Jie Lin4Jie Lin5Zaihong Hu6Zaihong Hu7Zhiqiang Gao8Zhiqiang Gao9XiaoMao Tian10XiaoMao Tian11Tao Lin12Tao Lin13Qinlin Shi14Qinlin Shi15Guanghui Wei16Guanghui Wei17Department of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaDepartment of Urology, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing, ChinaChongqing Key Laboratory of Structural Birth Defect and Reconstruction, Chongqing, ChinaBackgroundWilms tumor (WT), which represents about 90% of kidney tumors in children, is the most prevalent type of renal tumor among children. In developed countries, advancements in treatments such as chemotherapy and radiotherapy have led to high survival rates. However, developing countries face significant challenges, including late-stage diagnosis, metastasis at presentation, and high rates of treatment abandonment.MethodsThis retrospective study included all patients diagnosed with WT at a tertiary hospital in Western China from 2007 to 2021. It involved the collection of sociodemographic and clinical details, including data on patients who abandoned treatment. Follow-up continued until July 2024.ResultsThis study consisted of 301 WT patients. Of the 259 who completed the treatment, the 5-year event-free survival (EFS) and overall survival (OS) rates were 77.9% and 81.2%. Of the 42 patients who abandoned treatment, 13 refused further care immediately after diagnosis and signed a refusal document, 16 discontinued treatments during preoperative neoadjuvant chemotherapy, and 13 failed to complete the prescribed chemotherapy or radiotherapy.ConclusionSurvival rates for WT patients at our institution approach those reported in developed countries. Challenges include late-stage diagnosis, metastasis at initial presentation, and treatment abandonment. To address these issues, implementing pediatric screening is critical for early detection and timely intervention, particularly for families vulnerable to abandoning treatment. For high-risk cases, oncologists need develop targeted strategies to enhance clinical outcomes.https://www.frontiersin.org/articles/10.3389/fped.2025.1527039/fullWilms tumorprognosisoutcomesabandonmentglobal review |
| spellingShingle | Kongkong Cui Kongkong Cui Peng Hong Peng Hong Jie Lin Jie Lin Zaihong Hu Zaihong Hu Zhiqiang Gao Zhiqiang Gao XiaoMao Tian XiaoMao Tian Tao Lin Tao Lin Qinlin Shi Qinlin Shi Guanghui Wei Guanghui Wei Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China Frontiers in Pediatrics Wilms tumor prognosis outcomes abandonment global review |
| title | Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China |
| title_full | Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China |
| title_fullStr | Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China |
| title_full_unstemmed | Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China |
| title_short | Hope and challenges in the diagnosis and treatment of Wilms tumor: a single-center retrospective study in China |
| title_sort | hope and challenges in the diagnosis and treatment of wilms tumor a single center retrospective study in china |
| topic | Wilms tumor prognosis outcomes abandonment global review |
| url | https://www.frontiersin.org/articles/10.3389/fped.2025.1527039/full |
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