Gut microbiota and tuberculosis
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a significant global health challenge. Recent advancements in gut microbiota (GM) research have shed light on the intricate relationship between GM and TB, suggesting that GM alterations may influence host susceptibility...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-08-01
|
| Series: | iMeta |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/imt2.70054 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849229059257532416 |
|---|---|
| author | Yanhua Liu Ling Yang Maryam Meskini Anjana Goel Monique Opperman Sagar Singh Shyamal Ajay Manaithiya Meng Xiao Ruizi Ni Yajing An Mingming Zhang Yuan Tian Shuang Zhou Zhaoyang Ye Li Zhuang Linsheng Li Istuti Saraswat Ankita Kar Syed Luqman Ali Shakir Ullah Syed Yasir Ali Shradha Kaushik Tianmu Tian Mingyang Jiao Shujun Wang Giulia Ghisleni Alice Armanni Sara Fumagalli WenYu Wang Chao Cao Maria Carpena Miguel A. Prieto Antonia Bruno Chanyuan Jin Hanqing Hu Yuhang Zhang Ilse du Preez Ashok Aspatwar Lingxia Zhang Wenping Gong |
| author_facet | Yanhua Liu Ling Yang Maryam Meskini Anjana Goel Monique Opperman Sagar Singh Shyamal Ajay Manaithiya Meng Xiao Ruizi Ni Yajing An Mingming Zhang Yuan Tian Shuang Zhou Zhaoyang Ye Li Zhuang Linsheng Li Istuti Saraswat Ankita Kar Syed Luqman Ali Shakir Ullah Syed Yasir Ali Shradha Kaushik Tianmu Tian Mingyang Jiao Shujun Wang Giulia Ghisleni Alice Armanni Sara Fumagalli WenYu Wang Chao Cao Maria Carpena Miguel A. Prieto Antonia Bruno Chanyuan Jin Hanqing Hu Yuhang Zhang Ilse du Preez Ashok Aspatwar Lingxia Zhang Wenping Gong |
| author_sort | Yanhua Liu |
| collection | DOAJ |
| description | Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a significant global health challenge. Recent advancements in gut microbiota (GM) research have shed light on the intricate relationship between GM and TB, suggesting that GM alterations may influence host susceptibility, disease progression, and response to antituberculosis drugs. This review systematically synthesizes and analyzes the current research progress on the relationship between GM and TB, focusing on six key aspects: (1) bidirectional effects between GM dynamics and TB progression; (2) the interaction between GM and anti‐TB drugs; (3) GM and TB immune response; (4) GM as a potential target for diagnosis and treatment of TB; (5) multi‐omics and artificial intelligence (AI) technologies in GM‐TB research; (6) current challenges and future directions in GM‐TB research. We highlight the bidirectional nature of the GM–TB interaction, where MTB infection can lead to GM dysbiosis, and changes can affect the host's immune response, contributing to TB onset and progression. Advanced molecular techniques, such as next‐generation sequencing and metagenomics, along with AI, play pivotal roles in elucidating these complex interactions. Future research directions include investigating the relationship between GM and TB vaccine efficacy, exploring GM's potential in TB prevention, developing microbiome‐based diagnostic and prognostic tools, and examining the role of GM in TB recurrence. By addressing these areas, we aim to provide a comprehensive perspective on the latest advancements in GM and TB research and offer insights for future studies and clinical applications. Ultimately, the development of novel microbiome‐based strategies may offer new tools and insights for the effective control and management of TB, a disease that continues to pose a significant threat to public health. |
| format | Article |
| id | doaj-art-e9d4f9fd2d494dbda9846ff7d11b219d |
| institution | Kabale University |
| issn | 2770-596X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | iMeta |
| spelling | doaj-art-e9d4f9fd2d494dbda9846ff7d11b219d2025-08-22T08:13:03ZengWileyiMeta2770-596X2025-08-0144n/an/a10.1002/imt2.70054Gut microbiota and tuberculosisYanhua Liu0Ling Yang1Maryam Meskini2Anjana Goel3Monique Opperman4Sagar Singh Shyamal5Ajay Manaithiya6Meng Xiao7Ruizi Ni8Yajing An9Mingming Zhang10Yuan Tian11Shuang Zhou12Zhaoyang Ye13Li Zhuang14Linsheng Li15Istuti Saraswat16Ankita Kar17Syed Luqman Ali18Shakir Ullah19Syed Yasir Ali20Shradha Kaushik21Tianmu Tian22Mingyang Jiao23Shujun Wang24Giulia Ghisleni25Alice Armanni26Sara Fumagalli27WenYu Wang28Chao Cao29Maria Carpena30Miguel A. Prieto31Antonia Bruno32Chanyuan Jin33Hanqing Hu34Yuhang Zhang35Ilse du Preez36Ashok Aspatwar37Lingxia Zhang38Wenping Gong39Institute of Tuberculosis, Senior Department of Tuberculosis the Eighth Medical Center of PLA General Hospital Beijing ChinaInstitute of Tuberculosis, Senior Department of Tuberculosis the Eighth Medical Center of PLA General Hospital Beijing ChinaDepartment of Mycobacteriology and Pulmonary Research Pasteur Institute of Iran Tehran IranDepartment of Biotechnology GLA University Mathura IndiaCentre for Human Metabolomics North‐West University Potchefstroom South AfricaDepartment of Pharmaceutical Engineering & Technology Indian Institute of Technology (Banaras Hindu University) Varanasi IndiaFaculty of Medicine and Health Technology Tampere University Tampere FinlandComputer Network Information Center Chinese Academy of Sciences Beijing ChinaGraduate School Hebei North University Zhangjiakou ChinaGraduate School Hebei North University Zhangjiakou ChinaGraduate School Hebei North University Zhangjiakou ChinaGraduate School Hebei North University Zhangjiakou ChinaGraduate School Hebei North University Zhangjiakou ChinaGraduate School Hebei North University Zhangjiakou ChinaGraduate School Hebei North University Zhangjiakou ChinaGraduate School Hebei North University Zhangjiakou ChinaDepartment of Biotechnology GLA University Mathura IndiaICMR NHRP project‐Assam Medical College Dibrugarh IndiaDepartment of Biochemistry Abdul Wali Khan University Mardan PakistanDepartment of Zoology Abdul Wali Khan University Mardan PakistanDepartment of Pathology Abdul Wali Khan University Mardan PakistanDepartment of Biotechnology Institute of Engineering and Technology Lucknow IndiaSchool of Management Science and Engineering Beijing University of Information Science and Technology Beijing ChinaDepartment of Prosthodontics Peking University School and Hospital of Stomatology & National Health Commission Stomatology Computer Application Engineering Technology Research Center & National Center for Stomatology Beijing ChinaSchool and Hospital of Stomatology China Medical University, Liaoning Provincial Key Laboratory of Oral Disease Shenyang ChinaBiotechnology and Biosciences Department University of Milano‐Bicocca Milan ItalyBiotechnology and Biosciences Department University of Milano‐Bicocca Milan ItalyBiotechnology and Biosciences Department University of Milano‐Bicocca Milan ItalyBeijing Anzhen Hospital Capital Medical University Beijing ChinaDepartment of Respiratory and Critical Care Medicine, Key Laboratory of Respiratory Disease of Ningbo The First Affiliated Hospital of Ningbo University Ningbo ChinaUniversidade de Vigo, Nutrition and Food Group (NuFoG), Department of Analytical Chemistry and Food Science Instituto de Agroecoloxía e Alimentación (IAA) – CITEXVI Vigo SpainUniversidade de Vigo, Nutrition and Food Group (NuFoG), Department of Analytical Chemistry and Food Science Instituto de Agroecoloxía e Alimentación (IAA) – CITEXVI Vigo SpainBiotechnology and Biosciences Department University of Milano‐Bicocca Milan Italy2nd Dental Center Peking University School and Hospital of Stomatology Beijing ChinaSchool of Management Science and Engineering Beijing University of Information Science and Technology Beijing ChinaInstitute of Clinical Pharmacology Peking University First Hospital Beijing ChinaCentre for Human Metabolomics North‐West University Potchefstroom South AfricaFaculty of Medicine and Health Technology Tampere University Tampere FinlandInstitute of Tuberculosis, Senior Department of Tuberculosis the Eighth Medical Center of PLA General Hospital Beijing ChinaInstitute of Tuberculosis, Senior Department of Tuberculosis the Eighth Medical Center of PLA General Hospital Beijing ChinaAbstract Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a significant global health challenge. Recent advancements in gut microbiota (GM) research have shed light on the intricate relationship between GM and TB, suggesting that GM alterations may influence host susceptibility, disease progression, and response to antituberculosis drugs. This review systematically synthesizes and analyzes the current research progress on the relationship between GM and TB, focusing on six key aspects: (1) bidirectional effects between GM dynamics and TB progression; (2) the interaction between GM and anti‐TB drugs; (3) GM and TB immune response; (4) GM as a potential target for diagnosis and treatment of TB; (5) multi‐omics and artificial intelligence (AI) technologies in GM‐TB research; (6) current challenges and future directions in GM‐TB research. We highlight the bidirectional nature of the GM–TB interaction, where MTB infection can lead to GM dysbiosis, and changes can affect the host's immune response, contributing to TB onset and progression. Advanced molecular techniques, such as next‐generation sequencing and metagenomics, along with AI, play pivotal roles in elucidating these complex interactions. Future research directions include investigating the relationship between GM and TB vaccine efficacy, exploring GM's potential in TB prevention, developing microbiome‐based diagnostic and prognostic tools, and examining the role of GM in TB recurrence. By addressing these areas, we aim to provide a comprehensive perspective on the latest advancements in GM and TB research and offer insights for future studies and clinical applications. Ultimately, the development of novel microbiome‐based strategies may offer new tools and insights for the effective control and management of TB, a disease that continues to pose a significant threat to public health.https://doi.org/10.1002/imt2.70054artificial intelligencegut microbiotamicrobiome‐based diagnosticsMycobacterium tuberculosisomics technologiestuberculosis |
| spellingShingle | Yanhua Liu Ling Yang Maryam Meskini Anjana Goel Monique Opperman Sagar Singh Shyamal Ajay Manaithiya Meng Xiao Ruizi Ni Yajing An Mingming Zhang Yuan Tian Shuang Zhou Zhaoyang Ye Li Zhuang Linsheng Li Istuti Saraswat Ankita Kar Syed Luqman Ali Shakir Ullah Syed Yasir Ali Shradha Kaushik Tianmu Tian Mingyang Jiao Shujun Wang Giulia Ghisleni Alice Armanni Sara Fumagalli WenYu Wang Chao Cao Maria Carpena Miguel A. Prieto Antonia Bruno Chanyuan Jin Hanqing Hu Yuhang Zhang Ilse du Preez Ashok Aspatwar Lingxia Zhang Wenping Gong Gut microbiota and tuberculosis iMeta artificial intelligence gut microbiota microbiome‐based diagnostics Mycobacterium tuberculosis omics technologies tuberculosis |
| title | Gut microbiota and tuberculosis |
| title_full | Gut microbiota and tuberculosis |
| title_fullStr | Gut microbiota and tuberculosis |
| title_full_unstemmed | Gut microbiota and tuberculosis |
| title_short | Gut microbiota and tuberculosis |
| title_sort | gut microbiota and tuberculosis |
| topic | artificial intelligence gut microbiota microbiome‐based diagnostics Mycobacterium tuberculosis omics technologies tuberculosis |
| url | https://doi.org/10.1002/imt2.70054 |
| work_keys_str_mv | AT yanhualiu gutmicrobiotaandtuberculosis AT lingyang gutmicrobiotaandtuberculosis AT maryammeskini gutmicrobiotaandtuberculosis AT anjanagoel gutmicrobiotaandtuberculosis AT moniqueopperman gutmicrobiotaandtuberculosis AT sagarsinghshyamal gutmicrobiotaandtuberculosis AT ajaymanaithiya gutmicrobiotaandtuberculosis AT mengxiao gutmicrobiotaandtuberculosis AT ruizini gutmicrobiotaandtuberculosis AT yajingan gutmicrobiotaandtuberculosis AT mingmingzhang gutmicrobiotaandtuberculosis AT yuantian gutmicrobiotaandtuberculosis AT shuangzhou gutmicrobiotaandtuberculosis AT zhaoyangye gutmicrobiotaandtuberculosis AT lizhuang gutmicrobiotaandtuberculosis AT linshengli gutmicrobiotaandtuberculosis AT istutisaraswat gutmicrobiotaandtuberculosis AT ankitakar gutmicrobiotaandtuberculosis AT syedluqmanali gutmicrobiotaandtuberculosis AT shakirullah gutmicrobiotaandtuberculosis AT syedyasirali gutmicrobiotaandtuberculosis AT shradhakaushik gutmicrobiotaandtuberculosis AT tianmutian gutmicrobiotaandtuberculosis AT mingyangjiao gutmicrobiotaandtuberculosis AT shujunwang gutmicrobiotaandtuberculosis AT giuliaghisleni gutmicrobiotaandtuberculosis AT alicearmanni gutmicrobiotaandtuberculosis AT sarafumagalli gutmicrobiotaandtuberculosis AT wenyuwang gutmicrobiotaandtuberculosis AT chaocao gutmicrobiotaandtuberculosis AT mariacarpena gutmicrobiotaandtuberculosis AT miguelaprieto gutmicrobiotaandtuberculosis AT antoniabruno gutmicrobiotaandtuberculosis AT chanyuanjin gutmicrobiotaandtuberculosis AT hanqinghu gutmicrobiotaandtuberculosis AT yuhangzhang gutmicrobiotaandtuberculosis AT ilsedupreez gutmicrobiotaandtuberculosis AT ashokaspatwar gutmicrobiotaandtuberculosis AT lingxiazhang gutmicrobiotaandtuberculosis AT wenpinggong gutmicrobiotaandtuberculosis |