MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study)
In 2004–2016 we prospectively observed 59 oncohematology patients with mucormycosis; 21 children and 38 adults. The most frequent underlying diseases were acute myeloid leukemia and acute lymphoblastic leukemia (64 %); and main risk factors were сytostatic chemotherapy and allogeneic HSCT with prolo...
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| Language: | Russian |
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ABV-press
2017-06-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/237 |
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| author | N. N. Klimko S. N. Khostelidi O. V. Shadrivova T. S. Bogomolova Y. L. Avdeenko A. G. Volkova M. O. Popova I. A. Mihailova A. S. Kolbin E. G. Boychenko N. V. Medvedeva E. I. Podoltseva A. V. Klimovich M. B. Belogurova I. S. Zuzgin O. S. Uspenskaya V. N. Semelev N. I. Ponomoreva G. K. Abdilova L. S. Zuborovskaya B. V. Afanasiev |
| author_facet | N. N. Klimko S. N. Khostelidi O. V. Shadrivova T. S. Bogomolova Y. L. Avdeenko A. G. Volkova M. O. Popova I. A. Mihailova A. S. Kolbin E. G. Boychenko N. V. Medvedeva E. I. Podoltseva A. V. Klimovich M. B. Belogurova I. S. Zuzgin O. S. Uspenskaya V. N. Semelev N. I. Ponomoreva G. K. Abdilova L. S. Zuborovskaya B. V. Afanasiev |
| author_sort | N. N. Klimko |
| collection | DOAJ |
| description | In 2004–2016 we prospectively observed 59 oncohematology patients with mucormycosis; 21 children and 38 adults. The most frequent underlying diseases were acute myeloid leukemia and acute lymphoblastic leukemia (64 %); and main risk factors were сytostatic chemotherapy and allogeneic HSCT with prolonged (median – 30 days) neutropenia and lymphocytopenia. The etiology agents were Rhizopus spp. (47 %); Rhizomucor spp. (28 %); Lichtheimia corуmbifera (17 %) and Mucor spp. (8 %). Lichtheimia corуmbifera was found more often in children; Rhizopus and Mucor spp. in adults. Pulmonary mucormycosis was main clinical form (73 %); and ≥2 organs involvement was noted in 44 % patients. Antifungal therapy was used in 78 % patients; surgery – in 47 %. In treated with antifungals patients 12 weeks overall survival was 59 %. The positive prognostic factors were remission of underlying disease and combination antifungal therapy. |
| format | Article |
| id | doaj-art-e9d1769078024c53bf8a5840bfcc7263 |
| institution | DOAJ |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2017-06-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-e9d1769078024c53bf8a5840bfcc72632025-08-20T03:21:28ZrusABV-pressОнкогематология1818-83462413-40232017-06-01122142210.17650/1818-8346-2017-12-2-14-22234MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study)N. N. Klimko0S. N. Khostelidi1O. V. Shadrivova2T. S. Bogomolova3Y. L. Avdeenko4A. G. Volkova5M. O. Popova6I. A. Mihailova7A. S. Kolbin8E. G. Boychenko9N. V. Medvedeva10E. I. Podoltseva11A. V. Klimovich12M. B. Belogurova13I. S. Zuzgin14O. S. Uspenskaya15V. N. Semelev16N. I. Ponomoreva17G. K. Abdilova18L. S. Zuborovskaya19B. V. Afanasiev20North-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovNorth-Western State Medical University named after I.I. MechnikovI.P. Pavlov First Saint Petersburg State Medical UniversityI.P. Pavlov First Saint Petersburg State Medical UniversityChildren City Hospital No 1Children City Hospital No 1City Clinical Hospital No 31City Clinical Hospital No 31City Clinical Hospital No 31City Clinical Hospital No 31N.N. Petrov Research Institute of OncologyLeningrad Regional Clinical HospitalS.M. Kirov Military Medical AcademyRussian Children Clinical HospitalRepublican State Fiscal Organization Scientific Center of Pediatrics and Pediatric SurgeryI.P. Pavlov First Saint Petersburg State Medical UniversityI.P. Pavlov First Saint Petersburg State Medical UniversityIn 2004–2016 we prospectively observed 59 oncohematology patients with mucormycosis; 21 children and 38 adults. The most frequent underlying diseases were acute myeloid leukemia and acute lymphoblastic leukemia (64 %); and main risk factors were сytostatic chemotherapy and allogeneic HSCT with prolonged (median – 30 days) neutropenia and lymphocytopenia. The etiology agents were Rhizopus spp. (47 %); Rhizomucor spp. (28 %); Lichtheimia corуmbifera (17 %) and Mucor spp. (8 %). Lichtheimia corуmbifera was found more often in children; Rhizopus and Mucor spp. in adults. Pulmonary mucormycosis was main clinical form (73 %); and ≥2 organs involvement was noted in 44 % patients. Antifungal therapy was used in 78 % patients; surgery – in 47 %. In treated with antifungals patients 12 weeks overall survival was 59 %. The positive prognostic factors were remission of underlying disease and combination antifungal therapy.https://oncohematology.abvpress.ru/ongm/article/view/237acute leukemiamucormycosislichtheimia corymbiferamucorposaconazolerhizopusrhizomucor |
| spellingShingle | N. N. Klimko S. N. Khostelidi O. V. Shadrivova T. S. Bogomolova Y. L. Avdeenko A. G. Volkova M. O. Popova I. A. Mihailova A. S. Kolbin E. G. Boychenko N. V. Medvedeva E. I. Podoltseva A. V. Klimovich M. B. Belogurova I. S. Zuzgin O. S. Uspenskaya V. N. Semelev N. I. Ponomoreva G. K. Abdilova L. S. Zuborovskaya B. V. Afanasiev MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study) Онкогематология acute leukemia mucormycosis lichtheimia corymbifera mucor posaconazole rhizopus rhizomucor |
| title | MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study) |
| title_full | MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study) |
| title_fullStr | MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study) |
| title_full_unstemmed | MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study) |
| title_short | MUCORMYCOSIS IN ONCOHEMATOLOGY PATIENTS (results of the prospective study) |
| title_sort | mucormycosis in oncohematology patients results of the prospective study |
| topic | acute leukemia mucormycosis lichtheimia corymbifera mucor posaconazole rhizopus rhizomucor |
| url | https://oncohematology.abvpress.ru/ongm/article/view/237 |
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