Exploring the Gating Mechanism of the Human Copper Transporter, hCtr1, Using EPR Spectroscopy

Exploring the Gating Mechanism of the Human Copper Transporter, hCtr1, Using EPR Spectroscopy

Ctr1 is a membrane-spanning homotrimer that facilitates copper uptake in eukaryotic cells with high affinity. While structural details of the transmembrane domain of human Ctr1 have been elucidated using X-ray crystallography and cryo-EM, the transfer mechanisms of copper and the conformational chan...

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Bibliographic Details
Main Authors: Shahaf Peleg, Shelly Meron, Yulia Shenberger, Lukas Hofmann, Lada Gevorkyan-Airapetov, Sharon Ruthstein
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Biomolecules
Subjects:
copper transporter
copper metabolism
hCtr1
EPR spectroscopy
Online Access:https://www.mdpi.com/2218-273X/15/1/127
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