Estimation of Complement Components (C3 and C4) and hs-CRP Level in Kidney Failure Patients
Several kidney diseases associated with complement activation. Complement activation occurs in progressive chronic kidney disease and may contribute to the chronic inflammation that is characteristically found in the kidney. This study was aimed to detect the level of complement system in kidney fai...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Erbil Polytechnic University
2019-12-01
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| Series: | Polytechnic Journal |
| Subjects: | |
| Online Access: | https://polytechnic-journal.epu.edu.iq/home/vol9/iss2/12 |
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| Summary: | Several kidney diseases associated with complement activation. Complement activation occurs
in progressive chronic kidney disease and may contribute to the chronic inflammation that is
characteristically found in the kidney. This study was aimed to detect the level of complement system in
kidney failure patients. This study was included (30) patients with renal failure and (15) healthy donors
as control group. Serum samples separated from the whole blood of patients and healthy individuals.
C3, C4, and high sensitive C- reactive protein (hsCRP) levels were estimated for all samples. The
results were analyzed according to patients who were dialysis, non-dialysis, with diabetes, without
diabetes, with high blood pressure, and without high blood pressure. The results showed that there was
a significant increase (P < 0.05) in C3 level for patients with renal failure (154.12 mg/dl) compared
to control group (126.08 mg/dl) while C4 level for renal failure patients (35.38 mg/dl) showed no
significant change compared to control group (36.26 mg/dl). However, C3 level of patients under dialysis
(152.15 mg/dl), not dialysis (162.01 mg/dl), with diabetic (155.80 mg/dl), and without diabetic (153
mg/dl) recorded significant elevation compared with control group (126.08 mg/dl) but C4 level did not
show any significant change for all groups. C3 and C4 concentrations did not record significant alteration
(P < 0.05) in patient with hypertension, nonhypertension, and control group. Moreover, seropositivity
of CRP for patients with renal failure was ranged from 33.33% to 60% in all patients groups included
in this study. hsCRP concentration significantly elevated (P < 0.05) in under dialysis (1.787 mg/L),
nondialysis (1.583 mg/L), with diabetic (2.766 mg/L), nondiabetic (1.066 mg/L), with hypertension
(1.84 mg/L), and nonhypertension (1.26 mg/L) when compared with control group (0.667 mg/L). The
present findings suggest that the increased serum levels of C3, C4, and hs-CRP reflect the of kidney
injury. Hence, this reflects the complement system as an important mediator of kidney injury and the
role of anti-complement therapy in nephropathy will expand in the future. |
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| ISSN: | 2707-7799 |