Acute LPS exposure enhances susceptibility to peripheral prion infection

Abstract After peripheral infections, the initial accumulation of prions within secondary lymphoid tissues is essential for the transmission of disease to the brain. Macrophages are considered to sequester or destroy prions, but little was known of their impact on disease susceptibility after a peri...

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Bibliographic Details
Main Authors: Reiss Pal, Charlotte M. Thomas, Khalid Salamat, Stephen J. Jenkins, Barry M. Bradford, Neil A. Mabbott
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
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Online Access:https://doi.org/10.1038/s41598-025-94003-3
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