Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species
This study analyses characteristics of lung injuries produced by alveolar overdistension in three animal species. Mechanical ventilation at normal tidal volume (10 mL/Kg) and high tidal volume (50 mL/Kg) was applied for 30 min in each species. Data were gathered on wet/dry weight ratio, histological...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/985923 |
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| author | Manuel García-Delgado Inés Navarrete-Sánchez Virginia Chamorro-Marín Juan Carlos Díaz-Monrové Javier Esquivias Enrique Fernández-Mondéjar |
| author_facet | Manuel García-Delgado Inés Navarrete-Sánchez Virginia Chamorro-Marín Juan Carlos Díaz-Monrové Javier Esquivias Enrique Fernández-Mondéjar |
| author_sort | Manuel García-Delgado |
| collection | DOAJ |
| description | This study analyses characteristics of lung injuries produced by alveolar overdistension in three animal species. Mechanical ventilation at normal tidal volume (10 mL/Kg) and high tidal volume (50 mL/Kg) was applied for 30 min in each species. Data were gathered on wet/dry weight ratio, histological score, and area of alveolar collapse. Five out of six rabbits with high tidal volume developed tension pneumothorax, and the rabbit results were therefore not included in the histological analysis. Lungs from the pigs and rats showed minimal histological lesions. Pigs ventilated with high tidal volume had significantly greater oedema, higher neutrophil infiltration, and higher percentage area of alveolar collapse than rats ventilated with high tidal volume. We conclude that rabbits are not an appropriate species for in vivo studies of alveolar overdistension due to their fragility. Although some histological lesions are observed in pigs and rats, the lesions do not appear to be relevant. |
| format | Article |
| id | doaj-art-e9c25a9ab4bc4cfd9c17465c44559c14 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-e9c25a9ab4bc4cfd9c17465c44559c142025-02-03T01:12:50ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/985923985923Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal SpeciesManuel García-Delgado0Inés Navarrete-Sánchez1Virginia Chamorro-Marín2Juan Carlos Díaz-Monrové3Javier Esquivias4Enrique Fernández-Mondéjar5Intensive Care Unit, Hospital Universitario Virgen de las Nieves, 18014 Granada, SpainIntensive Care Unit, Hospital Universitario Virgen de las Nieves, 18014 Granada, SpainExperimental Unit, Hospital Universitario Virgen de las Nieves, 18014 Granada, SpainEmergency and Critical Care Department, Hospital SAS, 11407 Jerez, SpainPathology Department, Hospital Universitario San Cecilio, 18012 Granada, SpainIntensive Care Unit, Hospital Universitario Virgen de las Nieves, 18014 Granada, SpainThis study analyses characteristics of lung injuries produced by alveolar overdistension in three animal species. Mechanical ventilation at normal tidal volume (10 mL/Kg) and high tidal volume (50 mL/Kg) was applied for 30 min in each species. Data were gathered on wet/dry weight ratio, histological score, and area of alveolar collapse. Five out of six rabbits with high tidal volume developed tension pneumothorax, and the rabbit results were therefore not included in the histological analysis. Lungs from the pigs and rats showed minimal histological lesions. Pigs ventilated with high tidal volume had significantly greater oedema, higher neutrophil infiltration, and higher percentage area of alveolar collapse than rats ventilated with high tidal volume. We conclude that rabbits are not an appropriate species for in vivo studies of alveolar overdistension due to their fragility. Although some histological lesions are observed in pigs and rats, the lesions do not appear to be relevant.http://dx.doi.org/10.1100/2012/985923 |
| spellingShingle | Manuel García-Delgado Inés Navarrete-Sánchez Virginia Chamorro-Marín Juan Carlos Díaz-Monrové Javier Esquivias Enrique Fernández-Mondéjar Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species The Scientific World Journal |
| title | Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species |
| title_full | Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species |
| title_fullStr | Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species |
| title_full_unstemmed | Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species |
| title_short | Alveolar Overdistension as a Cause of Lung Injury: Differences among Three Animal Species |
| title_sort | alveolar overdistension as a cause of lung injury differences among three animal species |
| url | http://dx.doi.org/10.1100/2012/985923 |
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