Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report
Epstein–Barr virus-positive mucocutaneous ulcer (EBVMCU) is a rare condition characterized by skin or mucosal lesions resulting from defective immune surveillance of EBV due to immunosuppression, which can be iatrogenic or age-related. It represents a benign lymphoproliferative disorder that clinica...
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| Format: | Article |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2024.1458606/full |
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| author | Jiayuan Ye Shengqiang Ji Zhouxiao Wu Genhua Ma Jing Chen Shimin Wu Yilian Xie |
| author_facet | Jiayuan Ye Shengqiang Ji Zhouxiao Wu Genhua Ma Jing Chen Shimin Wu Yilian Xie |
| author_sort | Jiayuan Ye |
| collection | DOAJ |
| description | Epstein–Barr virus-positive mucocutaneous ulcer (EBVMCU) is a rare condition characterized by skin or mucosal lesions resulting from defective immune surveillance of EBV due to immunosuppression, which can be iatrogenic or age-related. It represents a benign lymphoproliferative disorder that clinically may mimic malignant tumors. However, EBVMCU typically progresses slowly and often resolves spontaneously without specific treatment, emphasizing the critical need for differential diagnosis from malignancies. In this study, we report a case of EBVMCU in an elderly patient demonstrating ulcers on the oral mucosa, buccal area, and maxillary mucosa, with associated bone destruction, which was initially suspected to be an oral malignancy but was confirmed as EBVMCU through biopsy. This case underscores the importance of considering EBVMCU in elderly patients with unexplained persistent mucosal ulcers to exclude malignancies. In addition, attention should be given to unhealthy lifestyle habits such as smoking and drinking, as well as poor oral hygiene, which are potential factors that increase the risk of this disease and contribute to worse prognoses. |
| format | Article |
| id | doaj-art-e9c2025eb81f4a319280fe790e41c382 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-e9c2025eb81f4a319280fe790e41c3822025-02-07T10:13:57ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011110.3389/fmed.2024.14586061458606Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case reportJiayuan Ye0Shengqiang Ji1Zhouxiao Wu2Genhua Ma3Jing Chen4Shimin Wu5Yilian Xie6Department of Infectious Diseases, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, ChinaNingbo Clinical Pathology Diagnosis Center, Ningbo, ChinaHealth Science Center, Ningbo University, Ningbo, ChinaDepartment of Dermatology, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, ChinaDepartment of Dermatology, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, ChinaDepartment of Gastroenterology, Shangyu People’s Hospital of Shaoxing, Shaoxing University, Shaoxing, ChinaDepartment of Infectious Diseases, The First Affiliated Hospital of Ningbo University, Ningbo, ChinaEpstein–Barr virus-positive mucocutaneous ulcer (EBVMCU) is a rare condition characterized by skin or mucosal lesions resulting from defective immune surveillance of EBV due to immunosuppression, which can be iatrogenic or age-related. It represents a benign lymphoproliferative disorder that clinically may mimic malignant tumors. However, EBVMCU typically progresses slowly and often resolves spontaneously without specific treatment, emphasizing the critical need for differential diagnosis from malignancies. In this study, we report a case of EBVMCU in an elderly patient demonstrating ulcers on the oral mucosa, buccal area, and maxillary mucosa, with associated bone destruction, which was initially suspected to be an oral malignancy but was confirmed as EBVMCU through biopsy. This case underscores the importance of considering EBVMCU in elderly patients with unexplained persistent mucosal ulcers to exclude malignancies. In addition, attention should be given to unhealthy lifestyle habits such as smoking and drinking, as well as poor oral hygiene, which are potential factors that increase the risk of this disease and contribute to worse prognoses.https://www.frontiersin.org/articles/10.3389/fmed.2024.1458606/fullEpstein–Barr virusEpstein–Barr virus-positive mucocutaneous ulcerage-related immunosuppressionmandibular necrosiscase report |
| spellingShingle | Jiayuan Ye Shengqiang Ji Zhouxiao Wu Genhua Ma Jing Chen Shimin Wu Yilian Xie Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report Frontiers in Medicine Epstein–Barr virus Epstein–Barr virus-positive mucocutaneous ulcer age-related immunosuppression mandibular necrosis case report |
| title | Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report |
| title_full | Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report |
| title_fullStr | Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report |
| title_full_unstemmed | Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report |
| title_short | Age-related immunosenescence and Epstein–Barr virus-positive mucocutaneous ulcer presenting as oral cancer: a case report |
| title_sort | age related immunosenescence and epstein barr virus positive mucocutaneous ulcer presenting as oral cancer a case report |
| topic | Epstein–Barr virus Epstein–Barr virus-positive mucocutaneous ulcer age-related immunosuppression mandibular necrosis case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2024.1458606/full |
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